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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Novel sites of A-to-I RNA editing in the mammalian brain /

Ohlson, Johan, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Stockholms universitet, 2007. / Härtill 4 uppsatser.
42

Translational control of mRNAs transcribed from HIV-1 provirus and HIV-1 based lentiviral vectors

Yilmaz, Alper, January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 139-161).
43

Kinetoplastid RNA editing : analysis of the mechanism of guide RNA directed uridylate insertion into precursor messenger RNA /

Kable, Moffett Lee. January 1998 (has links)
Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [87]-96).
44

Role of phenylalanyl-tRNA synthetase in translation quality control

Ling, Jiqiang, January 2008 (has links)
Thesis (Ph. D.)--Ohio State University, 2008. / Title from first page of PDF file. Includes vita. Includes bibliographical references (p. 119-137).
45

Interactions between mRNA and Escherichia coli ribosomes that contribute to the formation of translation initiation complexes

Brock, Jay Edward. January 2006 (has links)
Thesis (Ph. D.)--Miami University, Dept. of Microbiology, 2006. / Title from second page of PDF document. Includes bibliographical references (p. 160-176).
46

Physics and bioinformatics of RNA

Liu, Tsunglin, January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 102-108).
47

Analysis of the expression and function of chicken protocadherin 1 in neural crest cell migration and peripheral nervous system formation

Bononi, Judy. January 2007 (has links) (PDF)
Thesis (Ph.D.)--Montana State University--Bozeman, 2007. / Typescript. Chairperson, Graduate Committee: Roger Bradley. Includes bibliographical references (leaves 122-140).
48

Using sodium bisulphite treatment and PCR to construct mammalian anti-HIV-1 long hairpin RNA expression cassettes

Lugongolo, Masixole Yvonne 03 May 2012 (has links)
M.Tech. / RNA interference (RNAi) is a gene silencing mechanism that uses short RNA duplexes to block gene expression. This mechanism has been widely explored to determine functions of genes. Furthermore, this phenomenon has been used to silence unwanted genes such as viral genes. RNAi has been successfully employed in non-mammalian organisms such as plants, where long dsRNAs (more than 30 bp) have been used without inducing non-specific effects. However, in mammalian cells, cytoplasmic dsRNAs of more than 30 bp trigger non-specific induction of many genes, which may result from the activation of dsRNA-dependent protein kinase (PKR) and 2’,5’-oligoadenylate synthetase (2’,5’-OAS), via the interferon response pathway. In this study, we describe a novel and simple strategy to overcome nonspecific effects induced by longer RNA duplexes. This strategy uses sodium bisulphite which is a mutagen that deaminates cytosine residue to uracil residues in order to introduce mutations in the sense strand of the duplex. Introduction of these mutations results in the formation of G:U pairings between the sense and antisense strands of the long hairpin RNA. RNA duplexes with mismatches have been shown to be able to prevent interferon induction in mammalian cells. According to the obtained results, long hairpins RNA with and without mismatches were unable to inhibit the expression of the target region, which was the U5 region of the HIV-1 subtype C LTR. The U5 region of the LTR is actively involved in the reverse transcription of HIV-1. Therefore silencing of this region would have led to the inhibition or reverse transcription blockage. Furthermore, data showed that the interferon response was induced when using these long hairpin RNA duplexes. Due to the sensitivity of mammalian cells, the action of sodium bisulphite could have stimulated certain genes of the interferon pathway. Even though hairpins constructed in this study were unable to prevent the induction of the interferon response pathway and also could not silence the target, this strategy of using sodium bisulphite has a great potential as shown by its ability to induce changes in cytosine residues and leaving other nucleotides unchanged.
49

Optimal gRNA design of different CRISPR-Cas systems for DNA and RNA editing

Zhu, Houxiang 29 April 2019 (has links)
No description available.
50

Adar editing, the missing mechanistic puzzle piece underpinning the pathology of neurological symptoms and disorders

Plonski, Noel-Marie, Ph.D 05 July 2022 (has links)
No description available.

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