Radiation therapy has a significant role in the management of cancer patients. Computed tomography (CT) has been at the forefront of radiation therapy planning due to its widespread diagnostic use and its electron density information. Magnetic resonance (MR) imaging is another proven diagnostic modality, which can achieve superior soft tissue contrast and margin delineation, relative to CT. As such it has become a valuable tool for cancer diagnoses and staging. In this study, a centre-out radial acquisition using an off-resonance reception (co-RASOR) MR sequence, sensitive to magnetic field inhomogeneity, was applied to excite a broader frequency range of spins in the vicinity of metallic seeds. The resultant images display local hyperintensities around metallic markers. These images were then reconstructed with frequency offsets to rewind these hyperintensities to the geometric centre to obtain positive contrast. The contrast-to-noise ratio (CNR) was measured between a fiducial and its surrounding to compare Fourier and iterative reconstruction methods for undersampled co-RASOR. The motivation was to reduce the sequence acquisition time, while preserving sufficient CNR and resolution. For single slices, acquisition was 2.8 sec and multi-slice acquisition could acquire more than 50 slices in 73 sec, by reducing the acquired data by a factor of 8. This effectively encodes acquisition to 1.4 sec/slice. The noise present in undersampled images decreased significantly using iterative reconstruction methods, but a total variation based penalty better preserved the edges. Further extensions to the reconstruction method applied frequency-based filters that could isolate signals from different metallic compounds. The local hyperintensities rewind using opposite signed frequency offsets for diamagnetic and paramagnetic seeds. This allowed individual visualization of a low dose rate (LDR) brachytherapy seed and a gold fiducial marker. Phantom validation showed that each seed contains its maximal CNR in opposing frequency regions. The relative difference between global and local maxima in each frequency band ranged from 1.19 -- 3.73, and a single cut-off frequency was successfully applied for each acquisition plane. Image guidance systems rely on the position of these fiducial markers to compare daily setup images with CT and MR simulations. Phantom experiments and porcine tissue samples were used to assess the minimum separation of fiducials, geometric accuracy, and random errors associated with using the co-RASOR sequence. co-RASOR images were able to resolve fiducials separated by 0.5 - 1 cm, depending on image resolution. No systematic biases were observed by comparing co-RASOR to CT using rigid body registrations. The standard deviation of the systematic errors were \textless 0.5 mm between MR and CT registrations, and \textless 0.4 mm between MR scans without CT. These values are smaller than the current total systematic uncertainties, which should be limimed to <3 mm. The methods presented here can aid in understanding the trade-offs between acquisition speed and signal properties, differentiating cases where brachytherapy seeds are used in combination with fiducial markers for external beam boost, and aid in co-registration of multimodality imaging. / Thesis / Doctor of Philosophy (PhD)

Closer attention has been given to the acoustic noise performance of electric motors as electrified powertrains penetrate into the transportation system. Particularly, switched reluctance machines (SRMs) introduce a new challenge to the acoustic noise aspects given that the radial force harmonics can excite the natural frequencies of the main circumferential modes. A practical understanding of the radial force density decomposition is crucial in identifying the primary source of acoustic noise at different operating points, and it is one of the contributions of this thesis. An analytical expression is introduced to identify the temporal harmonic orders that excite different spatial mode shapes. The mode excitation is investigated along with the sound pressure level (SPL) produced by the primary vibrating mode shapes. Acoustic noise characteristics for each mode and the corresponding natural frequency at different speeds have been analyzed by using a waterfall plot. The acoustic noise generation by conventionally controlled SRMs prevents its use on applications where acoustic comfort is required. Acoustic noise is radiated by the stator frame when a vibration mode is excited by the respective spatial order at a forcing frequency that is close to the stator's modal natural frequency. The excitation surface wave is the radial force density waveform as a function of time and spatial position. From the harmonic content analysis, a phase radial force shaping method is for switched reluctance machines is proposed. A generic function for the radial force shape is identified, whose parameters are calculated by an optimization algorithm to minimize the torque ripple for a given average torque. From the phase radial force, a current reference is obtained. The proposed methodology is experimentally validated, with a four-phase 8/6 SRM, by acoustic noise measurements at different speeds and load torque conditions. / Thesis / Doctor of Philosophy (PhD)

When it comes to cell types, the cerebral cortex is one of the most diverse regions in the mammalian brain. Mouse cortical neurons are generated during development from radial glial cells (RGCs). But how these stem cells generate the different neuronal subtypes is still an open question. In the adult, transcription factors, specially homeobox genes, have been identified as determinants of neuronal types throughout the animal kingdom. Thus, in this study, we hypothesise that different subpopulations of neuronal progenitors (RGCs) give rise to subsequent subtypes of neurons in the cortex, and these populations can be defined by homeobox gene expression. Starting from a scRNA- seq analysis, we identified differentially expressed genes across different progenitor populations in the developing cortex: Adnp2, Homez and Hmbox1. We characterised their mRNA and protein expression across cortical layers in postnatal mice and found that these genes are also differentially expressed among layers. We also find discordances between scRNA-seq data, mRNA expression, and protein expression data that could indicate specific post-transcriptional regulation of these genes. Altogether, these results point to a role of homeobox genes in neuronal identity.

The current global scenario, in which an ever increasing population with an ever growing transportation needs is coupled with a reduction in the fossil fuel production and increasing human-made pollution derived problems, leads automotive engine manufacturers to constant struggles for fuel consumption and emission reductions while keeping engine performance. One-dimensional simulation codes have become a key tool towards these objectives, but require continued accuracy refinements. Phenomena that were previously thought of a limited importance and could be extremely easily modelled now require the development of new methods to be accounted for. Among these phenomena are the turbocharger mechanical losses and the turbine behaviour under highly pulsating boundary conditions. This work is focused on the improvement of current one-dimensional models, for both mechanical losses prediction and high frequency pulsating flow turbine performance. After reviewing the state-of-the-art in experimental measurement and fast simulation of automotive turbochargers, this work presents first a experimental study of several turbochargers working under both steady-state and unsteady operating conditions, focusing on the general performance of the turbine and the losses in the power transmission between it and the compressor, even including internal pressure measurements in one of the tested units. All the measurements are corrected due to heat transfer, getting the purely adiabatic behaviour. Furthermore, a CFD simulation campaign of a radial turbine has been performed, thus obtaining a detailed description of its internal behaviour under highly pulsating flow. In the light of both the experimental and CFD-simulated results, a quasi-steady mechanical losses and a quasi-bidimensional turbine model have been developed. Both models have been validated using all the experimental and simulated data, proving a prediction accuracy improvements from the results of previous methods. The mechanical losses model offers a clear advantage over the usual practice of using a constant mechanical efficiency value for correcting the manufacturer’s turbocharger map, whereas the turbine model has demonstrated potential for turbine map extrapolation and has improved the instantaneous results over classic onedimensional turbine volute models for frequencies higher than 1000 Hz. Both models have been developed trying to keep a reduced computational cost, ensuring to exploit the specific characteristics of the processors where they are going to be run. / García-Cuevas González, LM. (2014). Experiments and Modelling of Automotive Turbochargers under Unsteady Conditions [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/48458

[EN] Metamaterials are periodic structures whose unit cells are small compared to the wavelength at the operating frequency. Under these conditions, these artificial materials can be considered as homogeneous media whose constitutive parameters depend on the characteristics of the unit cells. The discovery of metamaterials opened a new research field that has produced many works with microwaves, optical waves and acoustic waves. In this context, the main goal of this thesis is the study of new structures based on metamaterials that allow controlling of electromagnetic energy. In particular, new solutions for localization and absorption of electromagnetic waves are proposed. The thesis has been developed in the Wave Phenomena Group of the Polytechnic University of Valencia and in collaboration with the Group of Acoustic and Electromagnetic Metamaterials at the University of Exeter. The problems studied in the first part of this thesis are energy harvesting for subsequent absorption, wireless power transfer and new systems that can be used as position sensors. To solve these problems a new type of cylindrical, multilayer and anisotropic structures known as Radial Photonic Crystals are used. The radial dependence of the constitutive parameters generates, in these structures, a behavior like a one dimensional photonic crystals. Among the results obtained with these structures, it is included the first experimental demonstration of a Radial Photonic Crystals based resonator. Absorption of electromagnetic waves by thin layers of lossy materials is the second topic of this thesis. The main target is the theoretical and experimental study of the absorption enhancement in thin layers by using two-dimensional periodic structures, also called metasurfaces. Specifically, we studied the effects of a square lattice of coaxial cavities covered by a thin layer of lossy material. As a result, an enhancement of the absorption peaks that can produce total absorption is achieved. The semi-analytical study of this structure has allowed obtaining expressions that control the position of the absorption peak and its amplitude; which have helped to develop a design methodology for total absorption systems. / [ES] Los metamateriales son estructuras periódicas cuyas celdas unidad son muy pequeñas en comparación con la longitud de onda a la frecuencia de trabajo. Bajo estas condiciones, estos materiales artificiales pueden considerarse como medios homogéneos cuyos parámetros constitutivos dependen de las características de las celdas unidad que los componen. La aparición de los metamateriales abrió un nuevo campo de investigación que ha generado multitud de trabajos en las líneas de microondas, óptica y acústica. En este contexto, el objetivo principal de esta tesis es el estudio de nuevas estructuras basadas en metamateriales que permitan el control de la energía electromagnética. En particular, plantea nuevas soluciones para problemas de localización y absorción de ondas electromagnéticas. La tesis ha sido desarrollada en el Grupo de Fenómenos Ondulatorios de la Universidad Politécnica de Valencia y en colaboración con el Grupo de Metamateriales Acústicos y Electromagnéticos de la Universidad de Exeter. Los problemas estudiados en la primera parte de esta tesis son la concentración de energía para su posterior absorción, la transferencia inalámbrica de potencia y nuevos sistemas capaces de ser empleados como sensores de posición. Para la solución de estos problemas se emplean un nuevo tipo de estructuras cilíndricas, multicapa y anisótropas conocidas como Cristales Fotónicos Radiales. La dependencia radial de los parámetros constitutivos de los materiales que componen cada una de sus capas genera, en estas estructuras, un comportamiento similar al de los cristales fotónicos unidimensionales. Entre los resultados obtenidos con estas estructuras, cabe destacar la primera demostración experimental de un resonador basado en Cristales Fotónicos Radiales. La absorción de ondas electromagnéticas por capas delgadas de materiales con pérdidas es el segundo tema tratado en esta tesis. El objetivo principal es el estudio teórico y experimental del aumento de la absorción en capas delgadas mediante el uso de estructuras periódicas bidimensionales, también llamadas metasuperficies. En concreto, se han estudiado los efectos de una red cuadrada de cavidades coaxiales sobre la que se coloca una capa delgada de un material con pérdidas. Como resultado, se consigue un aumento de la absorción que permite obtener picos de absorción total. El estudio semianalítico de esta estructura ha permitido obtener expresiones que controlan la posición del pico de absorción y su amplitud; las cuales han permitido desarrollar una metodología de diseño para sistemas de absorción total. / [CA] Els metamateriales són estructures periòdiques en els que les cel·les unitat són molt xicotetes en comparació amb la longitud d'ona a la freqüència de treball. Tenint en consideració aquestes condicions, aquestos materials artificials poden considerar-se com a mitjans homogenis en els que els paràmetres constitutius depenen de les característiques de les cel·les unitat que els componen. A més, l'aparició dels metamateriales va obrir un nou camp d'investigació que ha generat multitud de treballs en les línies de microones, òptica i acústica. En aquest context, l'objectiu principal d'aquesta tesi és l'estudi de noves estructures basades en metamateriales que permeten el control de l'energia electromagnètica. En particular, planteja noves solucions per a problemes de localització i absorció d'ones electromagnètiques. La tesi ha sigut realitzada en el Grup de Fenòmens Ondulatoris de la Universitat Politècnica de València i en col·laboració amb el Grup de Metamateriales Acústics i Electromagnètics de la Universitat d'Exeter. Els problemes analitzats en la primera part de la tesi són la concentració d'energia per a la seua posterior absorció, la transferència inalàmbrica de potència i nous sistemes capaços de ser empleats com a sensors de posició. Per a la solució dels problemas identificats s'utilitza un nou tipus d'estructures cilíndriques, multicapa i anisòtropes conegudes com a Cristalls Fotónics Radials. La dependència radial dels paràmetres constitutius dels materials que componen cadascuna de les seues capes genera, en aquestes estructures, un comportament semblant al dels Cristalls Fotónics Unidimensionals. Entre els resultats obtinguts, cal destacar la primera demostració experimental d'un ressonador basat en Cristalls Fotónics Radials. Pel que respecta a la segon part de la tesi, l'absorció d'ones electromagnètiques per capes primes de materials amb pèrdues és tema tractat. L'objectiu principal és l'estudi teòric i experimental de l'augment de l'absorció en capes primes per mitjà de l'ús d'estructures periòdiques bidimensionals, també denominades metasuperficies. En concret, s'han examinat els efectes d'una xarxa quadrada de cavitats coaxials sobre la qual es col·loca una capa prima d'un material amb pèrdues. Com a resultat, s'aconseguix un augment de l'absorció que permet obtindre pics d'absorció total. Així mateix, l'estudi semi-analític d'aquesta estructura ha permés obtindre expressions que controlen la posició del pic d'absorció i la seua amplitud; les quals han permés desenvolupar una metodologia de disseny per a sistemes d'absorció total. / Díaz Rubio, A. (2015). Control of electromagnetic energy by metamaterials [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/54137

With the growing need to meet aggressive emissions targets in the aerospace industry in the coming decades, the electrification of propulsion systems has become an area of great research and commercial interest. In order to achieve full electrification of larger commercial aircraft, it is critical to improve power and energy densities of components within the propulsion system. The power densities of electric motors are steadily rising to meet this requirement. Among the various motor designs available, the high-speed radial flux permanent magnet motor is presented as an architecture capable of achieving high efficiencies and power densities. Increasing power densities, however, poses challenges for the thermal management system as higher losses need to be dissipated from a relatively small machine package. One of the failure modes specific to permanent magnet motors is the demagnetization of the magnets in the rotor at higher temperatures which leads to a loss in performance. Therefore it is critical that the thermal management system of the rotor must effectively dissipate the losses generated in the magnets and other components within the rotor. This thesis discusses the mechanical and thermal design of a 150 kW high-speed radial flux surface mounted permanent magnet motor for aerospace propulsion applications. The thesis first introduces the current landscape of aerospace electrification, focusing specifically on electric and hybrid propulsion architectures, currently available electric motors for aerospace propulsion, and ongoing aircraft electrification projects. A review is then provided of the current state-of-the-art in rotor cooling designs for high-speed speed radial flux motors for traction applications before introducing the design of the motor proposed in this thesis. The discussion of the mechanical design provides a high level overview of the design, manufacturing, and assembly of the stator and rotating assemblies while the thermal design provides a brief overview of the stator cooling design and a deep dive on the rotor cooling design. Computational Fluid Dynamics (CFD) is used along with the Taguchi method for robust design to optimize the rotor cooling design for minimizing the magnet temperatures. Analysis for the optimized rotor cooling discussed is provided before providing recommendations for future work. / Thesis / Master of Applied Science (MASc)

A subsonic wind tunnel facility was designed and built to test and optimize various diffuser-collector box geometries at the one-twelfth scale.  The facility was designed to run continuously at an inlet Mach number of 0.42 and an inlet hydraulic diameter Reynolds number of 340,000. Different combinations of diffusers, hubs, and exhaust collector boxes were designed and evaluated for overall optimum performance. Both 3-hole and 5-hole probes were traversed into the flow to generate multiple diffuser inlet and collector exit performance profile plots. Surface oil flow visualization was performed to gain an understanding of the complex 3D flow structures inside the diffuser-collector subsystem. The cutback radial hardware was found to increase the subsystem pressure recovery by over 10% from baseline resulting in an approximate 1% increase in gas turbine power output. / Master of Science

RANS models in CFD are used to predict the liner wall heat transfer characteristics of a gas turbine annular combustor with radial swirlers, over a Reynolds number range from 50,000 to 840,000. A three dimensional hybrid mesh of around twenty five million cells is created for a periodic section of an annular combustor with a single radial swirler. Different turbulence models are tested and it is found that the RNG k-e model with swirl correction gives the best comparisons with experiments. The Swirl number is shown to be an important factor in the behavior of the resulting flow field. The swirl flow entering the combustor expands and impinges on the combustor walls, resulting in a peak in heat transfer coefficient. The peak Nusselt number is found to be quite insensitive to the Reynolds number only increasing from 1850 at Re=50,000 to 2200 at Re=840,000, indicating a strong dependence on the Swirl number which remains constant at 0.8 on entry to the combustor. Thus the peak augmentation ratio calculated with respect to a turbulent pipe flow decreases with Reynolds number. As the Reynolds number increases from 50,000 to 840,000, not only does the peak augmentation ratio decrease but it also diffuses out, such that at Re=840,000, the augmentation profiles at the combustor walls are quite uniform once the swirl flow impinges on the walls. It is surmised with some evidence that as the Reynolds number increases, a high tangential velocity persists in the vicinity of the combustor walls downstream of impingement, maintaining a near constant value of the heat transfer coefficient. The computed and experimental heat transfer augmentation ratios at low Reynolds numbers are within 30-40% of each other. / Master of Science

Gas turbine engines provide thrust for aircraft engines and supply shaft power for various applications. They consist of three main components. That is, a compressor followed by a combustion chamber (burner) and a turbine. Both turbine and compressor components are either axial or centrifugal (radial) in design. The combustion chamber is stationary on the engine casing. The type of engine that is of interest here is the gas turbine auxiliary power unit (APU). A typical APU has a centrifugal compressor, burner and an axial turbine. APUs generate mechanical shaft power to drive equipments such as small generators and hydraulic pumps. In airplanes, they provide cabin pressurization and ventilation. They can also supply electrical power to certain airplane systems such as navigation. In comparison to thrust engines, APUs are usually much smaller in design. The purpose of this research was to investigate the possibility of combining the three components of an APU into a single centrifugal rotor. To do this, a set of equations were chosen that would describe the new turbomachinery cycle. They either were provided or derived using quasi-one-dimensional compressible flow equations. A MathCAD program developed for the analysis obtained best design points for various cases with the help of an optimizer called Model Center. These results were then compared to current machine specifications (gas turbine engine, gasoline and diesel generators). The result of interest was maximum specific power takeoff. The results showed high specific powers in the event there was no restriction to the material and did not exhaust at atmospheric pressure. This caused the rotor to become very large and have a disk thickness that was unrealistic. With the restrictions fully in place, they severely limited the performance of the rotor. Sample rotor shapes showed all of them to have unusual designs. They had a combination of unreasonable blade height variations and very large disk thicknesses. Indications from this study showed that the single radial rotor turbomachinery design might not be a good idea. Recommendations for continuation of research include secondary flow consideration, blade height constraints and extending the flow geometry to include the axial direction. / Master of Science

<p dir="ltr">The Cascadia subduction zone features many along-strike variations in geophysical signatures that appear independent of properties in the subducting Juan de Fuca plate. Past studies have hypothesized that controls on these variations, namely subcretion, seem linked to overriding plate characteristics but may be influenced by characteristics of the downgoing slab as well. Nowhere is this more apparent than in southern Cascadia, which features the highest seismogenesis, broadest forearc topography, and lowest Bouguer gravity along the Cascadia margin. Additionally, the northward migration of deformation related to the San Andreas fault’s evolution and potential subslab buoyancies introduce further complexities making it difficult to parse contributions of tectonic processes to individual geophysical observations. To better understand contributions from Cascadia subduction and San Andreas evolution on tectonic processes, 60 Magseis Fairview nodal seismometers were deployed in southern Cascadia (Klamath Mountains) between April and May of 2020. We perform ambient noise tomography using Rayleigh and Love waves to constrain radial anisotropy and reveal seismic characteristics in the forearc. We find low VSV (<3.4 km/s) in the lower crust of the forearc consistent with previous studies. This is paired with high (>10%) positive radial anisotropy suggesting these materials are dominated by (sub)horizontal fabrics. We also observe relatively high VSV and VSH and negative radial anisotropy (~ -10%) in the upper crust of the forearc to ~10 km depth. These results suggest that the upper crust, which is dominated by the Klamath terrane, is characterized by (sub-vertical) deformational fabrics, likely related to brittle deformation superimposed on the accretionary history of the Klamath terrane, while the lower crust shows fabrics consistent with what would be expected due to basal accretion of oceanic crust (e.g, sedimentary rocks with or without basaltic slivers). The correlation of positive radial anisotropy with low shear-wave velocities (~3.4 km/s), low Bouguer gravity, high conductivity, and high rates of seismogenic activity (LFEs, tremor distribution, and episodic slow slip events) suggest that this basally accreted material may be infiltrated by fluids derived from the downgoing oceanic lithosphere.</p>