Made available in DSpace on 2014-10-09T12:28:11Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:01:45Z (GMT). No. of bitstreams: 0 / Os equipamentos de radiação X, por estarem ligados à rede elétrica, podem apresentar flutuações na intensidade de seus feixes de radiação. Essas variações na intensidade, podem, por sua vez, modificar a taxa de kerma no ar produzida por este feixe de radiação. Em um laboratório de calibração de instrumentos, onde são realizadas calibrações de diversos equipamentos detectores de radiação, utilizados principalmente em clínicas ou hospitais, essa possível variação na intensidade do feixe de radiação pode causar um erro na determinação da dose absorvida. As câmaras de ionização monitoras são utilizadas para verificar a constância da intensidade de feixes de radiação, e fornecer uma correção para possíveis oscilações. Neste trabalho foram projetadas, construídas e caracterizadas câmaras de ionização monitoras para feixes de radiação X. As câmaras de ionização desenvolvidas possuem formato inovador, anelar, com eletrodos de alumínio ou de grafite. Essas câmaras de ionização anelares apresentam a vantagem de não interferirem no feixe direto de radiação. Foi ainda construída uma câmara de ionização com volume duplo e eletrodos de grafite, similar à câmara de ionização monitora comercial utilizada no Laboratório de Calibração de Instrumentos do Instituto de Pesquisas Energéticas e Nucleares. Essas câmaras de ionização foram testadas em diversos feixes de radiação padronizados e seus desempenhos foram comparados aos de câmaras de ionização comerciais. Os resultados obtidos mostram que duas dentre as quatro câmaras de ionização desenvolvidas apresentaram desempenho comparável ao das câmaras de ionização comerciais testadas. Além de apresentarem bons resultados, as câmaras de ionização desenvolvidas foram feitas artesanalmente e utilizando materiais de baixo custo, que são facilmente encontrados no mercado. / Tese (Doutoramento) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

Made available in DSpace on 2014-10-09T12:33:24Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:24Z (GMT). No. of bitstreams: 0 / As câmaras de extrapolação são câmaras de ionização com volume variável e são utilizadas principalmente como detectores de radiação beta. Neste trabalho foram caracterizadas duas câmaras de extrapolação, uma comercial da marca PTW, e uma outra desenvolvida no Laboratório de Calibração do IPEN, para aplicação como sistemas de referência em feixes de mamografia, radiodiagnóstico convencional e radioterapia. Os resultados obtidos nos testes de caracterização da resposta das câmaras de extrapolação: corrente de fuga, estabilidade de curto e médio prazos, determinação das correntes de saturação e das eficiências de coleção de íons, dependência angular e energética, mostram que estas câmaras de extrapolação podem ser utilizadas em dosimetria de feixes de radiação X de energias baixas. Os fatores de transmissão no tecido e os fatores de calibração foram também determinados para todas as qualidades de radiação citadas. Finalmente, foi estabelecido um procedimento de calibração de detectores de radiação em feixes padronizados de radiação X, utilizando as câmaras de extrapolação. / Tese (Doutoramento) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

Made available in DSpace on 2014-10-09T12:26:01Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:10:08Z (GMT). No. of bitstreams: 1 00459.pdf: 1460675 bytes, checksum: 4ee7893eae68fa2c5b514f7d0a9872b8 (MD5) / Dissertacao (Mestrado) / IEA/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

The exposure to high doses of ionizing radiation (>5Gy) is unequivocally associated with increased cancer risk. However, there is substantial experimental evidence showing that in response to low doses of ionizing radiation (LDR: <100mGy), cells and organisms are benefitted with delayed ageing, improved immunity and reduced cancer growth. These intriguing findings have proposed the “Radiation Hormesis” hypothesis. Herein, I studied the senescence effects of LDR exposure to normal human HFL1 cells and examined transcriptional changes. I found that HFL1 cells exposed to 10 mGy of gamma radiation had delayed senescence measured at 12 weeks post-irradiation compared to unirradiated cells. Through qPCR array analysis, I found that genes involved in human cellular senescence functions are differentially regulated in 10 mGy exposed cells at 12 weeks compared to 1-week post-exposure. A nucleolar protein, SIRT7, that belongs to the family of proteins called Sirtuins with known roles in aging, was found to be upregulated transcriptionally in LDR-exposed HFL1 cells. Knocking out SIRT7 protein significantly accelerated senescence in HFL1 cells suggesting a direct role of SIRT7 in the deceleration of senescence and potentially in mediating radiation hormesis. Furthermore, overexpression of the HRAS oncogene strongly accelerated senescence in HFL1 cells through gene expression of cell cycle regulators and checkpoint proteins. Together, my studies revealed that LDR induces unique transcriptional changes resulting in a potentially radio adaptive protective cellular response. I also discuss the HRAS overexpression system as a time-efficient cellular model that could be used to more rapidly study the effect of LDR on senescence using primary cultures.

Using a micro-potometric method, it was ,found that X-irradiation (400 R - 18 Kr) of the shoots of the onion plant Allium cepa will produce an immediate, pronounced (200%) and reversible enhancement of the water uptake by the shielded roots. Unfiltered X-irradiation.(1200 R/min., 120 KVP, 5 ma) was delivered at right angles to the shoot. Readings were taken at 10-minute intervals before, and immediately following X-irradiation. The greatest enhancement occurred at dosages between 4.8 Kr (150%) and 6.0 Kr (190%). The data indicate that the irradiation effect on water uptake was a physical rather than a metabolic one.

No description available.

Thesis (M.Med. (Diagnostic Radiology)) -- University of Limpopo, 2022 / BACKGROUND: Ionizing radiation is detrimental to growing cells. The potential risk of any dose of radiation in growing cells can lead to permanent damage of basic cellular structure resulting in a high risk of developing cancer in children. Therefore, paediatric doctors need sufficient knowledge to protect their patients from late effects of radiation resulting from medical use. Most studies report poor knowledge of radiation safety measures among doctors. PURPOSE: The purpose of this study is to assess the knowledge of radiation safety and radiation doses among paediatric doctors in Pietersburg and Mankweng Hospitals, Limpopo province, South Africa. OBJECTIVE: To assess the paediatric doctors’ knowledge of radiation doses used in radiological diagnostic imaging examinations, as well as their knowledge of radiation safety measures. METHODOLOGY: This is a survey of paediatric doctors in the paediatrics general ward, paediatric oncology, intensive care and neonatal units, and paediatric surgery department, at Pietersburg and Mankweng Hospitals. A self-administered questionnaire with 23 items on knowledge of radiation safety and radiation doses emitted during normal radiological examinations is used to collect the data in May 2021. Data are analysed using Statistical Package for Social Sciences (SSPS) version 26.0 software. Chi-squared test is used to analyse the relationship between variables. Analysis of variance (ANOVA) is used to analyse the differences between variables. A p value of <0.05 is considered statistically significant. A total score of 50% in each section is used to denote adequate knowledge. The result are presented in charts and tables. RESULTS: Out of 52 paediatric doctors, 47 completed the questionnaire achieving a 90.4% response rate. Majority of participants were females (n = 31; 66%). Overall, only 10 (21.2%) of the participants scored 50% and above, including three consultants, two registrars, two medical officers and one medical officer intern. Twenty-five (53.1%) participants scored 50% and above on knowledge of radiation safety. Nearly half (44.7%) of the doctors were familiar with the concept of ALARA principle in radiation dose optimisation. Three participants scored more than 50% in the knowledge of radiation doses section. Only five (10.6%) and 17 (36%) participants correctly identified MRI and ultrasound, respectively, as the radiological diagnostic modalities that do not utilize ionizing radiation. CONCUSION: The level of knowledge of radiation safety and radiation doses among the paediatric doctors are poor. A very small number of the paediatric doctors were able to identify non-ionizing radiation modalities that can be used as an alternative to reduce radiation exposure to paediatrics during radiological investigations. Paediatric doctors will benefit from courses on radiation safety and radiation doses to improve their knowledge and/or eliminate unwarranted exposure of their patients to ionizing radiation.

Digitized by Kansas Correctional Industries / Department: Nuclear Engineering.

LD2668 .T4 1947 P38 / Master of Science

The role of high infrared (IR) reflectance in the temperature regulation of a single species of cactus, Cereus giganteus (saguaro cactus), was investigated. Two independent methods were used to determine the effect of high near-IR reflectance on C. giganteus stem temperatures. The first method was to measure the surface temperature of two individual plants of comparable size and health, one of which was partially shaded by a canopy of loose sun-screening material. The second method involved the numerical solution on a computer of the energy balance, or heat transfer, equation for C. giganteus. High reflectance at near-IR wavelengths was found to decrease the peak surface temperature reached by C. giganteus by 3.2 to 3.3°C. This figure is valid for the fairly mild environmental conditions encountered in the Sonoran Desert at an altitude of 940 m during late September and early October.