Thesis (Ph. D.)--Earth and Atmospheric Sciences, Georgia Institute of Technology, 2005. / Davis, Douglas, Committee Member ; Huey, Greg, Committee Member ; Nenes, Athanasios, Committee Member ; Weber, Rodney, Committee Member ; Whetten, Robert, Committee Member ; Wine, Paul H., Committee Chair. Includes bibliographical references.

Thesis (M. Sc.)--Carleton University, 2000. / Includes bibliographical references. Also available in electronic format on the Internet.

Thesis (Ph.D)--Earth and Atmospheric Sciences, Georgia Institute of Technology, 2010. / Committee Chair: Wine, Paul; Committee Member: Huey, Greg; Committee Member: Mulholland, James; Committee Member: Nenes, Athanasios; Committee Member: Weber, Rodney. Part of the SMARTech Electronic Thesis and Dissertation Collection.

Thesis (doctoral)--Lund University, 1995. / Added t.p. with thesis statement inserted.

Thesis (Ph.D.)--McMaster University, 2003. / Advisor: Johan K. Terlouw. Includes bibliographical references. Also available via World Wide Web.

Thesis (Ph. D.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 177-202). Also available on the World Wide Web.

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 280-284).

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 217-233).

Made available in DSpace on 2014-10-09T12:37:49Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T13:56:14Z (GMT). No. of bitstreams: 1 05378.pdf: 4874406 bytes, checksum: 5202dee2fe2fd96e7538be3969e8b4c4 (MD5) / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

The role of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) in atherosclerosis remains elusive. Several researchers argued whether iNOS and/or NO are pathogenic or cardio protective. The pathogenesis of atherosclerosis is complex and includes mechanisms associated with inducible nitric oxide synthase (iNOS). We have demonstrated that the expression and function of iNOS may be selectively down regulated by pro-oxidants such as antimycin A and diethyl maleate (DEM). To further explore the underlying mechanisms associated with these effects we have investigated whether antimycin A and/or DEM modulated the activation of key cellular signalling molecules associated with the induction of iNOS. Expression of p38 mitogen activated kinase (MAPK) and Akt were induced by exposure to lipopolysaccharide (LPS) and interferon-gamma (IFN-γ). Oxidative stress (OS) was induced using antimycin A, DEM and hydrogen peroxide (H2O2). All three OS inducers caused a significant generation of free radicals whereas only antimycin A and DEM generated superoxide radical (O2-). Also nitrite production and iNOS expression may be down regulated, in part; by pro-oxidants generating O2- but not hydroxyl radicals (OH-). Antimycin A and DEM concentration dependently inhibited the phosphorylation of p38 MAPK and Akt and this was restored when the cells were pre-treated with Atorvastatin whereas H2O2 was without any significant effect. Taken together, the data suggest novel actions for both pro-oxidants and atorvastatin which may have important implications in coronary artery disease where suppression of iNOS may be deleterious and maintaining its expression may be cardio-protective.