Issued also as Thesis (Ph. D.)--University of Michigan. / An experiment in maze learning, developed with fifteen albino rats. Bibliography: p. 64-65.

Issued also as Thesis--University of Chicago.

Thesis (Ph. D.)--University of Chicago, 1908. / "Published as Monograph supplement no. 48 of the Psychological review, 1909."

Thesis (M.S.P.H.)--University of Michigan, 1943.

Thesis (Ph. D.)--University of Hawaii at Manoa, 2003. / Includes bibliographical references (leaves 95-113).

Issued also as thesis (PH. D.) University of Michigan. / An experiment in maze learning, developed with fifteen albino rats. "References": p. 64-65.

Thesis (Ph. D.)--Illinois State University, 1996. / Title from title page screen, viewed May 30, 2006. Dissertation Committee: Maarten E. A. Reith (chair), Hou Tak Cheung, John W. Dailey, Robert L. Preston, Brian J. Wilkinson. Includes bibliographical references and abstract. Also available in print.

In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High fat diet + p (HFD + p), n=19In the high fat group male Wistar rats were fed ±55 g/day of a specialised high fat diet over a 46 week period to induce obesity and an insulin resistant state. The treatment groups (groups 2 and 4) received a dose concentration of a tea extract of the S. frutescens plant in their drinking water daily. This study showed that the consumption of S. frutescens significantly reduces weight gain in male Wistar rats on a chronic high fat diet (p≤0.001 vs. HFD control group). S. frutescens appears to propagate periportal and centrilobular glycogen storage in rat hepatocytes in the experimental groups as exemplified by a significantly (p≤0.0001 vs. control groups) increased incidences of Periodic Acid Schiff (PAS) positive staining S. frutescens also reduced intracellular lipid accumulation as made evident by the significantly lower incidence of epicardial adipose tissue (EAT), hepatic steatosis and pancreatic interstitial fat. Obesity was associated with increased fibrotic lesions such as myocardial perivascular fibrosis, centrilobular hepatic fibrosis and pancreatic periductal fibrosis. Obesity associated hypertension contributed to the widespread and significant increase in the average lesion severity of arterial congestion in all organs in the HFD control group. Pulmonary infection was equally prevalent in all rats. Despite the complex histopathology in all groups, differences in the control groups, such as, the presence of a conservative polymorphonuclear leukocyte (PMNL) infiltration, substantial intra-alveolar oedema and focal arterial wall hypertrophy in the control groups was highly suggestive of Sendai viral infection. However histopathologic evidence, in the treatment groups, suggested chronic recurrent viral infection with superimposed Mycoplasma pulmonis (M. pulmonis) bacterial infection. The impact of advanced suppurative pulmonary infection was widespread and exemplified by increased lesion incidences of spontaneous murine progressive cardiomyopathy (MCP) and spontaneous chronic progressive nephropathy (CPN) among others. In conclusion S. frutescens administered for 46 weeks to male Wistar rats significantly lowered intracellular lipid accumulation and obesity associated myocardial, renal, hepatobiliary, pulmonary and pancreatic histopathology. Moreover, duodenal, cardiovascular, hepatobiliary, pulmonary, renal, pancreatic and splenic tissue did not show histopathologic evidence of direct plant extract associated toxicity or carcinogenicity.

Hoarding or hoarding behavior refers to the active storing and accumulation of food or other objects by an animal. Hoarding is often experimentally defined as the act of transporting food or objects, from some area outside the Ss home cage, back to the home cage. A typical hoarding experiment involves manipulation of an independent variable (e. g., amount of food deprivation, previous experience, early experience, strain of rat .• choice of hoarding material}, followed by measurement of the number of food pellets or objects hoarded during daily 30 min. hoarding trials. A hoarding trial involves allowing the subject access to the hoarding material by means of an alleyway attached to its home cage. Ss then have an allotted amount of time (e.g., 30 min., 24 hrs.) in which to transport the hoarding material to their home cages. To insure hoarding will take place, Ss are often food deprived prior to the first of a set of hoarding trials, or prior to each daily hoarding trial. Though laboratory rats will hoard food without being food deprived (Bindra, 1948) deprivation prior to trials facilitates the amount of hoarding (Morgan, Stellar & Johnson, 1943; Guerra, 1970).

No description available.