Radio frequency identification (RFID) technology is adopted in supply chain as it possesses high potential for optimization. However, the adoption is constrained with management and technological issues for certain domains. Applicability and profitability of the technology and implementation approaches as well as maturity of the technology and data integration are few of the concerns in this regard. Therefore, many enterprises are still skeptical about investment in RFID technology. Rightly, for instance, there are no appropriate approaches for management of the RFID system implementations at present that consider specific concerns of preparation of the food manufacturing enterprises. This research suggests a reference model for the purpose. The model is a result of extensive literature reviews and practice-oriented research aiming practical solutions to the problems of the respective domain. The model, which involves planning, organization and realization of RFID system implementation activities, considers multiple facets of RFID system implementations in order to increase understanding of RFID technology (i.e. knowledge development), ease decision making of an RFID implementation (i.e. willingness), and reduce cost and complexity of RFID system implementations (i.e. effectiveness and efficiency). It is an artifact of design-oriented information system research and includes a frame of reference, a process model, input and output templates, and tools and techniques. The model is applied in ‘real life context’ in order to achieve objectives of the involved enterprises. Similarly, the model aims effectiveness and efficiency in the future use, for example, by providing free of cost acquisition and appropriateness for manufacturing industries of food businesses of Saxony-Anhalt. However, adaptation efforts (e.g. by instantiation or specialization) may vary depending on the skills of users of individual enterprises. The reference model provides flexibility in terms of independence from specific vendors, openness by complying with available standards (e.g. PMBOK), and relationship to RFID system development artifacts during technical work realization.