<p>The Swedish regions are new phenomena, from the start from the new regionalism which started in the 1980´s. The purpose of the thesis is to analyze Region Skåne and Västra Götalandsregionen to come to a conclusion which model of region they are and want to be by using theories of regional identity and identity of politics and see similarities and differences. My research question is: Which of cultural, administrative and functional region are Region Skåne and Västra Götaland striving to construct?</p><p>   The methods I have used are qualitative text- and content analysis to analyze the regions, by using theories about regional identity and identity of politics. Furthermore, I am using some statistic from SOM-institutet to analyze the regional identity in the regions.</p><p>   The result show that Region Skåne is constructing a cultural region, because of their strong regional identity and that the politicians are using identity of politics to combine the citizens. The citizens feel a strong fellowship and share a common history and culture.</p><p>   However Västra Götalandsregionen is an administrative region, there their regional identity is low and do not have a common history and culture. There the politicians’ focus is on administrative things, as research and communication.  </p>

Thesis (Ph. D.)--University of Missouri--Columbia, 2000. / "December 2000." Typescript. Vita. Includes bibliographical references (leaves 133-147). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / "August 2001." Typescript. Vita. Includes bibliographical references (leaves 135-149). Also available on the Internet.

Thesis (D. Miss.)--Concordia Theological Seminary, Ft. Wayne, 1997. / Abstract and vita. Includes bibliographical references (leaves 333-346) and indexes.

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 72-93).

Global competencies, with differences in terminology by various researchers, had been frequently investigated, primarily from an American-biased perspective. Little or no defining research existed that identified requisite, universally agreed upon global competencies, or identified what affective components were perceived to be important cross culturally. This research study answered the following questions: 1. What affective components are perceived to be important from a cross-cultural perspective? 2. Are there differences in these perceptions of affective components from a cross-cultural perspective? The purpose of the study was to explore the extent to which individuals in different GeoCultural regions view and identify affective components perceived to be important in today's global society. Affective components relate to emotions, values, and beliefs. The research entailed the development of two instruments for placing individuals within a primary region (the background information form) and for identifying and rating affective components perceived to be important in today's global society from a cross-cultural perspective (the affective component questionnaire). The study used four expert panels to perform content validation. Both instruments were developed by global experts from eight GeoCultural regions. As a result of the panel process, nine affective components were identified. Two instruments were administered, through intermediaries, to individuals in all the GeoCultural regions and subcategories. Of the responses, 423 were usable. Affective competence appears to be a complex construct that involves more than one component. Based on this study, there are at least nine different affective components perceived to be important in order to be a culturally competent individual in today's global society. All of the nine affective components were perceived to be important in all GeoCultural regions and subcategories. Repeated measures ANOVA and Dunn's pairwise comparisons tests were used to assess differences between the affective components and the GeoCultural regions/subcategories. There were differences found in three of the affective components indicating that there may be some differences between GeoCultural regions and subcategories. The Caribbean respondents did not value three affective components as highly as some of the other GeoCultural regions. Repeated measures ANOVAs were also used to determine if there were any significant differences between the subcategories of Asia and the subcategories of Oceania. Since no significant differences existed in either GeoCultural region, it lends support to the notion that the subcategories are not needed for research dealing with affective components.

Cell proliferation is a process that is strictly regulated by a large number of proteins. An alteration in one of the encoding genes inserts an error into the regulative protein, which may result in uncontrolled cell growth and eventually tumor formation. Lymphoma is a cancer type originating in the lymphocytes, which are part of the body’s immune defence. In the present thesis, Znfn1a1, Notch1 and Bcl11b were studied; all involved in the differentiation of T lymphocytes. The three genes are located in chromosomal regions that have previously shown frequent loss of heterozygosity in tumor DNA. Ikaros is a protein involved in the early differentiation of T lymphocytes. In this thesis, mutation analysis of the Znfn1a1 gene in chemically induced murine lymphomas revealed point mutations and homozygous deletions in 13 % of the tumors. All of the detected deletions lead to amino acid substitutions or abrogation of the functional domains in the Ikaros protein. Our results support the role of Ikaros as a potential tumor suppressor in a subset of tumors. Notch1 is a protein involved in many differentiation processes in the body. In lymphocytes, Notch1 drives the differentiation towards a T-cell fate and activating alterations in the Notch1 gene have been suggested to be involved in T-cell lymphoma. We identified activating mutations in Notch1 in 39 % of the chemically induced murine lymphomas, supporting the involvement of activating Notch1 mutations in the development of T-cell lymphoma. Bcl11b has been suggested to be involved in the early T-cell specification, and mutations in the Bcl11b gene has been identified in T-cell lymphoma. In this thesis, point mutations and deletions were detected in the DNA-binding zinc finger regions of Bcl11b in 15 % of the chemically induced lymphomas in C57Bl/6×C3H/HeJ F1 mice. A mutational hotspot was identified, where four of the tumors carried the same mutation. Three of the identified alterations, including the hotspot mutation in Bcl11b, increased cell proliferation when introduced in a cell without endogenous Bcl11b, whereas cell proliferation was suppressed by wild-type Bcl11b in the same cell line. Mutations in Bcl11b may therefore be an important contributing factor to lymphomagenesis in a subset of tumors. A germ line point mutation was identified in BCL11B in one of 33 human B-cell lymphoma patients. Expression of BCL11B in infiltrating T cells was significantly lower in aggressive compared to indolent lymphomas, suggesting that the infiltrating T cells may affect the B-cell lymphomas.

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