Today, many privacy abuses can be traced to the lack of organization policies governing the conduct of the personnel who are in charge of managing the information systems. IT professionals, who are the most important gatekeepers to the information privacy practices, have the oversight responsibility for information privacy since they have the most extensive knowledge of their organization¡¦s systems and data. In this research, we have studied the impact of managerial policies concerning ethical codes and rewards/penalty perception on IS professionals¡¦ self-regulation capacity against privacy abuses. Specificially, based upon the Moment-of-Truth model and paradigm of self-regulation, we investigated how IS professionals¡¦ ethical judgment, subjective norm, privacy self-efficacy and intention may reciprocally interact with their business environment that was characterized by its use of ethical codes and the rewards/penalty system. We first proposed an ethical dicision model based on the paradigm of self-regulation and validated the appropriateness of this model for studying information privacy. We then demonstrated how the perception of the rewards/penalty may impact the ethical judgment, subjective norm, privacy self-efficay, and ethical intention. We discovered that the rewards/penalty perception had a moderating effect on the relationship between ethical judgment and intention, and that the ethical codes had the moderating effect on the relationship between privacy self-efficacy and intention.

The Study of Customer Personal Data Protection In this customer-driven era, corporations and government agencies face the challenges from customers. If government and corporations can utilize the power of computers to manage the huge amount of personal data they have collected by storing and editing, data mining and customer relationship management can be put to use on services, customer cares, and marketing. This will increase the efficiency of government agencies and stimulate the development of economy. The government, corporations and the people all will be benefited from this move. However, while the organizations make large investments in the security of their computer systems to avoid the invasion of virus and hackers, the abuse and breach caused by the employees, contractors, and other legal users can compromise all the preventive measures. This study investigates the performance of customer personal data privacy protection. While discussing the regulations such as computer processing of personal data acts and Telecommunications Acts, the theory on which this study is based is Self-Regulation Mechanism. The Self-Regulation Mechanism can be applied to the self-monitoring, self-esteem, information ethics, and self-efficacy of the users who have access to the customer personal data. It can also be applied to the management of the customer personal data privacy at the organization level. This study gathered 432 valid surveys from the customer personal data users who are the customer service staffs in the telecommunication industry. With path analysis methodology, this study explores the interactions among the management of organization, personal privacy protection self-efficacy, and information ethics. With information ethics and self-efficacy as the intervening variable between the management of organization and protection performance, this study is set to clarify the level of impacts that these three items have over the performance of customer information privacy protection. Through the model validation, the customer personal data protection self-regulation mechanism proposed in this study demonstrates suitability and the management of organization also shows positive, direct and noticeable impacts. However, the effects of information ethics on privacy protection self-efficacy and those of self-efficacy on the performance of privacy protection are not obvious. Therefore, the organization should strengthen the information ethics of its employees and improve self-efficacy. Also, they should bring up feasible and solid suggestions, hoping to improve the customer personal privacy protection performance of the organization and its members. By doing the customers will have confidence in the organization. Winning the trust and satisfaction from the customers will promote the organization image and even bring in more business opportunities, a good thing for running a long term business.

Les NADPH oxydases constituent une famille d’enzymes dont la fonction est dédiée à la production de formes réactives de l’oxygène. NOX1, un des membres de cette famille, est abondamment exprimée dans le colon et sa dérégulation pourrait être associée aux maladies inflammatoires chroniques de l’intestin. Les mécanismes qui modulent l’activation de NOX1 demeurent mal connus. Au cours de ma thèse je me suis donc intéressée à l’étude de la phosphorylation de NOXA1 et NOXO1, deux sous-unités régulatrices du complexe NOX1 et ai démontré 1) que la phosphorylation de NOXA1 constitue un mécanisme de régulation négative de l’activité de NOX1 en vue de maintenir l’activité constitutive du complexe à un niveau adéquat et non excessif. 2) pour la première fois, que NOXO1β est phosphorylée et que cette phosphorylation entraîne une hyperactivation de NOX1. L’ensemble de ces données montre que NOX1 est finement régulée. Par ce biais, NOX1 pourrait être impliquée dans la défense anti-infectieuse de l’intestin. / The NOX family of NADPH oxidases are enzymes which function is dedicated to the production of reactive oxygen species. NOX1, a member of this family is expressed abundantly in the intestine and its disregulation could be linked to inflammatory diseases such as inflammatory bowel diseases. However, the molecular basis of NOX1 regulation remains unclear. During my thesis, I demonstrated that 1) NOXA1, the activator cytosolic subunit of the NOX1 complex, is phosphorylated and its phosphorylation prevents hyperactivation of NOX1 in order to maintain a constitutive activity which would not be too excessive. 2) phosphorylation of human NOXO1, the organizer subunit of the complex is a prerequisite of full activation of NOX1. Taken together, these results demonstrate that NOX1 is tightly regulated by phosphorylation events. By this mean, NOX1 could be involved in host immune defense of the intestine.

L'Homme est le bénéficiaire ultime et l'intrant essentiel du développement et de la croissance. Le capital humain identifié comme moteur de la croissance économique est fortement lié à la variable démographique. L'institution familiale par ses décisions de fécondité et d'investissement en éducation de ses membres est un préambule pour la formation du capital humain. L'intérêt est porté, alors, à l'interaction entre la quantité et la qualité de l'Homme. Notre étude de la croissance économique est conduite par l'analyse de la fécondité comme variable de croissance économique. Elle cherche à dégager les influences de la fécondité notamment par ses interactions avec l'éducation dans l'explication des performances économiques. Grâce à des analyses: macro et microéconomique, nous vérifions la présence d'une association éducation-fécondité et sa contribution dans le processus de la croissance pour la Tunisie. Une analyse quantitative dynamique du lien entre la fécondité, l'éducation et la croissance économique aussi bien à long terme qu'à court terme au cours de la période 1963-2007 est entreprise employant les techniques de séries temporelles. Aussi, une analyse quantitative de la fécondité : naturelle, désirée, réelle, de l'écart et de la régulation est mise en œuvre par des modèles micro économétriques tels que ceux de choix discret, de comptage et de durée. Elle prouve que le comportement des ménages est guidé par l'arbitrage entre la quantité et la qualité d'enfants et met en évidence les déterminants économiques et socioculturels. Ces analyses permettent d'annoncer les politiques cadrant le comportement familial de fécondité dans le processus de développement. / Human is the final benefit and the essential input of economic growth and development. Human capital as an economic growth driving force is strongly influenced by demographic variables. Family institution is a preliminary for human capital accumulation considering its fertility and education investment in its member's decision. Hence, human capital analysis leads necessary to endogenous population growth. Then, our interest is focused to human quantity and quality interaction. Our economic growth investigation is so conducted by analysing fertility as economic growth variable. Our essay is to put out fertility influences notably by its interaction with education in explaining economic performances. Referring to macro and micro economic family analysis, we verify education/fertility relationship and its contribution in the growth process in Tunisian case. A long and short dynamic quantitative analysis of fertility, education and growth equilibrium relationship over the period 1963-2007 is undertaken using times series technique. Although a quantitative analysis of actual, desired, their gap, natural and regulation fertility is applied using micro econometric models such as dichotomous model, count data model and duration model. It attests that Tunisian household behaviour is shaped by quantity-quality children trade-off and also highlights economic and sociocultural fertility determinants. These analyses give out policies matching family fertility behaviour in the development process.

Questa tesi descrive una modalità parsimoniosa di organizzare l'ampia evidenza prodotta in questi ultimi anni nel campo della salute mentale digitale. A tal fine, viene presentato il framework DIU (D per diffusione, I per miglioramento e U per comprensione). Questo quadro teorico è applicato al campo specifico della regolazione delle emozioni (ER) per i disturbi emotivi. L’obbiettivo è quello di fornire una descrizione dell'attuale cambiamento della psicopatologia e evidenziare il ruolo della ER come meccanismo di cambiamento transdiagnostico e transteorico. A tal fine, viene fornita una revisione di tutti gli sviluppi esistenti in ciascuna delle categorie del quadro DIU. Ogni sezione propone nuovi risultati empirici che mostrano come le terapie digitali possano aiutare a migliorare l'ER nei disturbi emotivi. Per realizzare tali contributi empirici, sono stati utilizzati svariati disegni di ricerca e diverse soluzioni statistiche a seconda dei diversi contesti in cui gli studi sono stati condotti. Nel complesso, questa tesi stimola la discussione su alcuni degli attuali dibattiti nell’area della psicologia clinica e suggerisce risposte teoriche ed empiriche al fine di migliorare il campo. / This dissertation describes a way of organising parsimoniously the ample existing evidence that has been produced along these years in the field of digital mental health. For that purpose the DIU framework is presented. That is, D for dissemination, I for improvement and U for understanding. This framework is applied to the specific field of emotion regulation in emotional disorders. In that sense, it presents a description of the current psychopathological transformation in order to outline the role of emotion regulation (ER) as a transdiagnostic and transtheorical mechanism of change. A review of all the existing developments in each of the categories of the DIU framework are described. Each section presents novel empirical results that show how digital interventions may serve to improve ER in emotional disorders. These empirical contributions used a variety of research designs and statistical solutions depending on the different contexts in which the studies were conducted. Overall, this dissertation boosts the discussion concerning some of the current debates in clinical psychology and suggests theoretical and empirical answers in order to improve the field.

This thesis deals with the project of the banking union of EU. The theoretical part contains an integrated description of this significant project, for example a reason of the formation, the explanation of all components and the legislation that is related to the banking union. The practical part analyses the real impacts of the banking union on the Czech Republic and Slovakia and the eventual impacts on Czech Republic, in case it decides to join the banking union.