Indiana University-Purdue University Indianapolis (IUPUI) / Non-invasive surface recording of bioelectric potentials continues to be an essential tool in a variety of research and medical diagnostic procedures. However, the integrity of these recordings, and hence the reliability of subsequent analysis, diagnosis, or recommendations based on the recordings, can be significantly compromised when various types of noise are allowed to penetrate the recording circuit and contaminate the signals. In particular, for bioelectric phenomena in which the amplitude of the biosignal is relatively low, such as muscle activity (typically on the order of millivolts) or neural traffic (microvolts), external noise may substantially contaminate or even completely overwhelm the signal. In such circumstances, the tissue-electrode interface is typically the primary point of signal contamination since its impedance is relatively high compared to the rest of the recording circuit. Therefore, in the recording of low-amplitude biological signals, it is of paramount importance to minimize the impedance of the tissue-electrode interface in order to consistently obtain low-noise recordings. The aims of the current work were (1) to complete the development of a set of tools for rapid, simple, and reliable full-spectrum characterization and analytical modeling of the complex impedance of the tissue-electrode interface, and (2) to characterize the interfacial impedance and signal-to-noise ratio (SNR) at the surface of the skin across a variety of preparation methods and determine a factor or set of factors that contribute most effectively to the reduction of tissue-electrode impedance and noise contamination during recording. Specifically, we desired to test an initial hypothesis that surface abrasion is the principal determining factor in skin preparation to achieve consistently low-impedance, low-noise recordings. During the course of this master’s study, (1) a system with portable, battery-powered hardware and robust acquisition/analysis software for broadband impedance characterization has been achieved, and (2) the effects of skin preparation methods on the impedance of the tissue-electrode interface and the SNR of surface electromyographic recordings have been systematically quantified and compared in human subjects. We found our hypothesis to be strongly supported by the results: the degree of surface abrasion was the only factor that could be correlated to significant differences in either the interfacial impedance or the SNR. Given these findings, we believe that abrasion holds the key to consistently obtaining a low-impedance contact interface and high-quality recordings and should thus be considered an essential component of proper skin preparation prior to attachment of electrodes for recording of small bioelectric surface potentials.

Indiana University-Purdue University Indianapolis (IUPUI) / The young field of gene therapy offers the promises of significant progress towards the treatment of many different types of human diseases. Gene therapy has been proposed as an innovative way to treat Acute Kidney Injury (AKI). Through proteomic analysis, the upregulation of two enzymes, IDH2 and SULT1C2, within the mitochondrial fraction has been identified following ischemic preconditioning, a treatment by which rat kidneys are protected from ischemia. Using the hydrodynamic fluid gene delivery technique, we were able to upregulate the expression of IDH2 and SULT1C2 in the kidney. We found that the delivery of IDH2 plasmid through hydrodynamic fluid delivery to the kidney resulted in increased mitochondrial oxygen respiration compared with injured kidneys without gene delivery. We also found that renal ischemic preconditioning altered the membrane fluidity of mitochondria. In conclusion, our study supports the idea that upregulated expression of IDH2 in mitochondria can protect the kidney against AKI, while the protective function of upregulated SULT1C2 needs to be further studied.

Background: Research is essential for the development of a unique body of knowledge, a hall mark of any profession. It should be utilised to provide the basis for professional theory and practice. Aim: The purpose of the study was to develop guidelines that will assist professional nurses in the utilisation of research findings. Design and setting: Quantitative, descriptive research was used to determine professional nurses’ (N=284) perception of utilization of research findings in practice. The structured questionnaire was used to collect data. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 23 since this is a quantitative study. The study focused on professional nurses at the two selected hospitals that were providing the comprehensive programme in the uMgungundlovu district. Results: 284 respondents answered the questionnaire. Of the respondents, 73.3% agreed that they lacked knowledge of research. The frequency of respondents that lacked research knowledge was 208. Of the respondents, 211 (74.3%) recommended use of research findings in practice versus 24 (8.5%) who were unsure and 9 (3%) respectively who did not know whether research should be used or not. Conclusions: The findings revealed that there is a need for changes to be made in the nursing education system to try and improve research utilisation by professional nurses in practice since the professional nurses working in the clinical area are produced by nursing education institutions / Health Studies / M.A. (Health Studies)

<p>Cilj rada je da se ukaţe na prednosti i ograniĉenja kvalitativnih istraţivaĉkih pristupa u saznavanju i unapreĊivanju pedago&scaron;ke stvarnosti, kao i da se ukaţe na mogućnosti i probleme kombinovanja kvalitativnih i kvantitativnih metoda u prouĉavanju odreĊenih pedago&scaron;kih problema. U prvom delu rada, razmatraju se teorijske pretpostavke koje leţe u osnovi kvalitativnih istraţivaĉkih pristupa, predstavljajući ih kao kritiĉke i kao komplementarne kvantitativnim pristupima. Diskutujemo o posebnim pitanjima koja smatramo vaţnim za polje kvalitativnog pedago&scaron;kog diskursa: o kriterijumima nauĉnosti, strategijama formiranja uzorka i relevantnosti ovih istraţivanja za praksu i planiranje obrazovne politike. Detaljnije su razmotrena tri kvalitativna istraţivaĉka pristupa: studija sluĉaja, etnografski pristup i akciono istraţivanje, odnosno dometi i ograniĉenja primene ovih pristupa u prouĉavanju pedago&scaron;kih fenomena. Na kraju prvog dela rada, raspravljamo o mogućnostima i ograniĉenjima istraţivaĉkih nacrta u kojima se kombinuju kvalitativne i kvantitativne metode. U drugom delu rada, na primeru na&scaron;eg akcionog istraţivanja u osnovnoj &scaron;koli ilustrujemo doprinos ovog pristipa saznavanju i menjanju pedago&scaron;ke stvarnosti. Reĉ je o razvijanju i evaluaciji alternativnog programa razredne nastave, ĉija je jedna od osnovnih karakteristika primena grupno-istraţivaĉkog modela uĉenja. U istraţivaĉkom nacrtu kombinovani su kvalitativni i kvantitativni postupci i tehnike za prikupljanje podataka. Detaljnije je prikazan deo rezultata istraţivanja koji se odnosi na primenu grupno-istraţivaĉkog rada uĉenika u nastavi na tematski organizovanim nastavnim sadrţajima Poznavanja dru&scaron;tva u ĉetvrtom razredu, kao ilustracija mogućnosti akcionog istraţivanja da doprinese lak&scaron;em uvoĊenju inovacija u pedago&scaron;ku praksu. U tom smislu, kao poseban doprinos istraţivanja, dajemo predlog za izmene u programskim sadrţajima ovog predmeta i pristupima za njihovo izuĉavanje.</p> / <p>The goal of this paper is to point out to the advantages and limitations of qualitative research approaches in learning about and advancing the pedagogical reality, as well as to point out to the possibilities and problems of combining qualitative and quantitative methods in studying certain pedagogical problems. In the first part of the paper, we discuss theoretical assumptions underlying qualitative research approaches, presenting them as critical and complementary to quantitative approaches. We discuss special issues that we consider important for the field of qualitative pedagogical discourse: the criteria of scientific nature, the strategies for sample formation and relevance of these types of research for practice and planning of educational policy. Three qualitative research approaches have been considered in more detail: case study, ethnographic approach and action research, that is, the scope and limitations of application of these approaches in studying pedagogical phenomena. In the end of the first part of the paper, we discuss the possibilities and limitations of research designs that combine qualitative and quantitative methods. In the second part of the paper, on the example of our action research in primary school, we illustrate the contribution of this approach to learning about and changing the pedagogical reality. We are dealing with the development and evaluation of an alternative program of primary school, which has as one of its basic characteristics the application of group-investigation model of learning. This research design combines qualitative and quantitative procedures and data collection techniques. There is a more detailed presentation of that portion of research results that refers to the application of group-investigation work of pupils in class on topically organised teaching contents of Social Science in the fourth grade, as an illustration of the possibilities of action research to contribute to the easier introduction of innovations in educational practice. In that sense, as a special contribution of this research, we provide a suggestion for changes in program contents of this subject and approaches to their studying.</p>

This thesis includes four essays, of which each comprises two original contributions. Based on this thesis’ eight contributions, we add knowledge or understanding to the literatures on responsible investment, research output analyses and investment performance evaluation. First, we develop the first generic, reliable approach to benchmark research area output (e.g. journal articles or books), which we expect to appeal to governments’ increasing interest in monitoring their research funding investments. Second, we apply this approach to the research area of responsible investment, which is currently backed by an about $ 7 trillion industry. We find that the (quality weighted) quantity of responsible investment’s research output is statistically significantly under-proportional compared with peer research areas. One of several explanations for this result lies in the intransparency of the current responsible investment literature. Third, we develop an approach to research synthesis, which improves a research area’s transparency without experiencing many weaknesses of conventional literature reviews. We title this approach Influential Literature Analysis (ILA). Fourth, we apply ILA to the relatively intransparent responsible investment literature. One of our many findings is that responsible assets with their ceteris paribus under-proportional total risk might appear artificially unattractive when assessed by the most common investment performance measure, the Sharpe ratio, which is biased in favour of high risk assets due to its currently unsolved negative excess return problem. Fifth, we develop a generic, reliable and robust solution to the negative Sharpe ratio problem, which investors can customise according to their specific increasing incremental disutility of risk functions. Six, we generalise our solution to the negative Sharpe ratio problem, which allows us to solve the negative (excess) return problems of over twenty other investment performance measures. Seventh, we develop independent, statistically sophisticated tests of the sufficiency and quality of suggested solutions to the negative Sharpe ratio problem, since all existing tests a-priori assume the superiority of a specific solution. In contrast, our tests are only based on the Sharpe ratio itself and two basic axioms of investment theory. Hence, they are conceptually unrelated to our solutions. Eighth, we apply these tests using two different data samples to all existing solutions to the negative Sharpe ratio problem. We find that investors are best advised to use our solutions, the H⁶-, H⁷- or H⁸-measure, in their evaluation of investment performance from a Sharpe ratio like perspective.

Conclusions. The sensitivity and positive predictive value are generally more concerned than the specificity and negative predictive value in assessing and adjusting publication bias in meta-analyses. In this sense, Egger's regression can be recommended for its high sensitivity, while any positive result from Tang's method would suggest a probability of bias that should be taken seriously. Given the different patterns of the accuracy with the OR and the P1-P2 combination, a combination of Egger's regression and Tang's regression would be advisable. Further studies are needed to study the accuracy of methods used in combination. / Due to sampling error and true heterogeneity, a single study cannot provide a comprehensive picture and a precise estimate of, say the effectiveness of a treatment. Systematic reviews that identify and integrate relevant studies have become the most important scientific, quantitative method to summarize scientific research. Meta-analysis is the statistical method used in systematic reviews to combine results from individual studies. / However, due to selective submission and publication, not all relevant studies conducted, especially those unpublished studies with an insignificant negative result, are easily accessible to those who conduct reviews. As a result, the truth, say, the effect of a treatment, would be overestimated. This phenomenon is known as publication bias. A few methods for detecting the bias have been developed and used in meta-analyses. Although their accuracy has been studied, some important issues remain to be answered, such as when would a method be good enough for practical use and is it similarly good for different definitions of the odds ratio? / Methods. We conducted a simulation study to examine the accuracy of four commonly used bias-detection methods with various ORs and P1-P2 combinations. In a simulation study, the true bias status can be predetermined and thus be compared with the results of the bias-detection methods. The four methods are Egger's regression, funnel plot regression, rank correlation regression, and Tang's regression. Realistic sample size was used for simulating individual studies and the numbers of studies in a meta-analysis was also varied. Both the sensitivity and specificity are examined against the magnitude of the OR and the P1-P 2 combination to identify the ORs and P1-P 2 combinations for which a method is sufficiently accurate. Predictive values are also examined for the same reason and in the same manner. / Results. The sensitivity and positive predictive value are generally low and in particular when the OR is close to one for which publication bias is of a particular concern. Egger's regression has the highest sensitivity among the four, in particular when the OR is neither close to one nor exceptionally large or small. Due to the relatively lower specificity, the positive predictive value of Egger's regression is not as high as that for Tang's regression and funnel plot regression. Tang's regression and funnel plot regression are very similar in sensitivity, specificity and predictive values, with the former being slightly better. Rank correlation seems the least accurate method overall. Tang's regression has in general the highest positive predictive value among the four methods in particular when the OR is below one. / Chung Chi-keung. / "June 2006." / Adviser: Tang Jin Ling. / Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1588. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2006. / Includes bibliographical references (p. 116-124). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.

Many academic decision makers rely on quantified ranking measures to estimate the quality of journal publications. The aim of this study was to map journals in Information Systems (IS) with regard to their topic and their rank and determine whether there is a relationship between the scope of a journal and its rank. The study used content analysis, applying both qualitative and quantitative methods. The results of the analysis show the existence of relationships between the journal rank, the research area, and the type as well as significant differences in ranking on the three lists. The findings illustrate that ranking measures, as indicators for the quality of research published in a journal ought to be considered only in the context of a particular research area and scientific community.

The purpose of this thesis is to contribute to the methodology at the intersection of relational and evaluative bibliometrics. Experimental investigations are presented that address the question of how we can most successfully produce estimates of the subject similarity between documents. The results from these investigations are then explored in the context of citation-based research evaluations in an effort to enhance existing citation normalization methods that are used to enable comparisons of subject-disparate documents with respect to their relative impact or perceived utility. This thesis also suggests and explores an approach for revealing the uncertainty and stability (or lack thereof) coupled with different kinds of citation indicators.This suggestion is motivated by the specific nature of the bibliographic data and the data collection process utilized in citation-based evaluation studies. The results of these investigations suggest that similarity-detection methods that take a global view of the problem of identifying similar documents are more successful in solving the problem than conventional methods that are more local in scope. These results are important for all applications that require subject similarity estimates between documents. Here these insights are specifically adopted in an effort to create a novel citation normalization approach that – compared to current best practice – is more in tune with the idea of controlling for subject matter when thematically different documents are assessed with respect to impact or perceived utility. The normalization approach is flexible with respect to the size of the normalization baseline and enables a fuzzy partition of the scientific literature. It is shown that this approach is more successful than currently applied normalization approaches in reducing the variability in the observed citation distribution that stems from the variability in the articles’ addressed subject matter. In addition, the suggested approach can enhance the interpretability of normalized citation counts. Finally, the proposed method for assessing the stability of citation indicators stresses that small alterations that could be artifacts from the data collection and preparation steps can have a significant influence on the picture that is painted by the citationindicator. Therefore, providing stability intervals around derived indicators prevents unfounded conclusions that otherwise could have unwanted policy implications. Together, the new normalization approach and the method for assessing the stability of citation indicators have the potential to enable fairer bibliometric evaluative exercises and more cautious interpretations of citation indicators.

Thesis (Ph. D.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 269-279).

Background: Research is essential for the development of a unique body of knowledge, a hall mark of any profession. It should be utilised to provide the basis for professional theory and practice. Aim: The purpose of the study was to develop guidelines that will assist professional nurses in the utilisation of research findings. Design and setting: Quantitative, descriptive research was used to determine professional nurses’ (N=284) perception of utilization of research findings in practice. The structured questionnaire was used to collect data. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 23 since this is a quantitative study. The study focused on professional nurses at the two selected hospitals that were providing the comprehensive programme in the uMgungundlovu district. Results: 284 respondents answered the questionnaire. Of the respondents, 73.3% agreed that they lacked knowledge of research. The frequency of respondents that lacked research knowledge was 208. Of the respondents, 211 (74.3%) recommended use of research findings in practice versus 24 (8.5%) who were unsure and 9 (3%) respectively who did not know whether research should be used or not. Conclusions: The findings revealed that there is a need for changes to be made in the nursing education system to try and improve research utilisation by professional nurses in practice since the professional nurses working in the clinical area are produced by nursing education institutions / Health Studies / M.A. (Health Studies)