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Στην παρούσα εργασία μελετάται η κυτταρική ανοσοαπόκριση σε ασθενείς με ιδιοπαθή θρομβοπενική πορφύρα. Αναλυτικότερα εξετάζονται οι επιμέρους υποπληθυσμοί λεμφοκυττάρων και οι κυτταροκινές που αυτά εκκρίνουν με την τεχνολογία της κυτταρομετρίας ροής. Ιδιαίτερη έμφαση έχει δοθεί στον υποπληθυσμό των ρυθμιστικών των λεμφοκυττάρων / In the present study we examine the immune response in patients with immune thrombocytopenic purrura. Using flow cytometry we examined the subpopulation of lymphocytes and cytokines they produce. We also examined the subpopulation of regulatory the cells who seems to play a crucial role in autoimmunity.

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / Introduction: With the increase in children diagnosed with autism spectrum disorders (ASD) each year comes the need for individualized interventions necessary for children with autism. Many of the treatments currently available are time consuming, costly, and rely heavily on behavioral interventionists despite the lack of qualified interventionists to provide these services. Therefore, there is a growing recognition of the need for efficient, cost-effective treatment models that involves families in the intervention. This study examined the effects of continuous parent training and feedback for 3 months in Pivotal Response Treatment (PRT) through telemedicine on responsivity to language opportunities in children with ASD versus a control group of parents receiving one week of PRT training alone. We hypothesized that with telemedicine support, the child’s verbal communication would increase. Methods: 30 child-parent dyads from Tucson, AZ were enrolled in this randomized control trial. Subjects were 24-60 months of age and met DSM-IV criteria for autism at the time of enrollment. All subjects received one week of intensive parent training at the Southwest Autism Research and Resource Center (SARRC) in PRT. The support group received telemedicine feedback three times weekly for three months. Data was analyzed using two sample t-tests and Wilcoxon rank sum tests. Results: The control group had a mean responsivity in function verbal utterances of 64.3% and the telemedicine group had a 62.7% verbal responsivity rate prior to initiation of telemedicine support. At three month follow-up, the control group had a mean responsivity rate of 58.6% and the telemedicine group had a mean responsivity of 64.3%. A two sample t-test showed a no significant difference between the two groups with a p-value of 0.51. Conclusions: This study did not find any significant difference between the telemedicine and control groups. However, there is a trend towards increased verbal communication in the telemedicine group. We therefore recommend further studies to determine the utility of telemedicine and parent training in PRT in the treatment of children with ASD.

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