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This thesis includes a review of scientific studies of tree injuries following mechanized thinning. Interviews have been made with drivers of single grip harvesters and forwarders in forest thinning and a number of essential factors have been identified as the most important to take into account in order to minimize and/orprevent injuries to stems and roots of remaining trees.

University of Macau / Faculty of Social Sciences. / Department of Communication

Wild-type transthyretin amyloidosis (ATTRwt) is a rare, sporadic protein misfolding disorder with no validated biomarkers or specific treatments. The disease is characterized by deposition of amyloid fibrils composed of wild-type transthyretin (TTR) in cardiac tissue, which leads to cardiomyopathy, heart failure, and death within 5 years. The hypothesis for the studies detailed in this dissertation was non-coding variants in the TTR gene regulatory regions impact expression and serum levels of the protein, thereby contributing to ATTRwt pathogenesis. Investigations included examination of 2 enhancer regions and the proximal promoter of the TTR gene for risk factors which could contribute to pathogenesis of ATTRwt amyloidosis. In total, 11 common and 20 rare variants were identified. The analyses demonstrated significant associations of 3 variants with increased disease risk and 4 variants with age at disease onset and/or survival. Functional studies using GFP and luciferase reporter assays in HepG2 cells were performed to examine the impact of nucleotide alterations in the TTR proximal promoter on reporter expression. Three ATTRwt-risk factors (rs3764479, rs72922940, rs3794885), caused significantly decreased reporter expression in both GFP and luciferase assays (p < 0.02). Moreover, serum TTR levels, measured by immunoturbidity and analyzed along with ATTRwt clinical data, demonstrated that lower serum TTR concentrations were associated with worse survival (hazard ratio = 0.89, p = 0.003). Follow-up analysis of an ATTRwt subset treated with diflunisal, a TTR stabilizer, showed increased serum TTR (p = 0.002) and organ improvement as assessed by cardiac biomarkers (p = 0.043). Unexpectedly, our genetic sequencing data suggested that the TTR G6S variant was disease-protective. Analysis of the TTR G6S protein using circular dichroism and aggregation assay corroborated these findings by demonstrating a higher structural stability and a lower aggregation propensity compared to L55P and V122I, two unstable amyloidogenic TTR variants. In summary, the major findings of this work were: 1) identification of genetic variants that confer risk for ATTRwt amyloidosis through changes in expression, 2) evidence in support of serum TTR as a candidate for monitoring disease progression and response to treatment, and 3) evidence suggesting that TTR G6S may confer protection from ATTRwt by slowing the amyloid cascade. / 2017-09-08T00:00:00Z

In the United States, hysterectomy is one of the most commonly performed operations for women that is not related with pregnancy. However, not enough attention has been paid to how women's exposure to the surgery differs according to their social characteristics as well attitudinal/behavioral factors. Using cohort data from the National Longitudinal Surveys of Mature Women, this study investigated two aspects: (1) the association between socioeconomic status and hysterectomy and (2) the impact of women's attitudinal/behavioral characteristics on hysterectomy. With Cox proportional hazards analyses, this study found that women's exposure to hysterectomy significantly differs according to their social and attitudinal standings. Social characteristics that were found to be statistically significant risk factors of hysterectomy include women's eduction, employment status, and marital status. Among additional and behavioral factors, women's locus of control and number of children were identified as statistically significant risk factors. These findings may be used to enhance consumer awareness of hysterectomy and aid in policy reconstruction.

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