The single row layout problem (SRLP) is a specially structured instance of the classical facility layout problem, especially used in flexible manufacturing systems. The SRLP consists of finding the most efficient arrangement of a given number of machines along one side of the material handling path with the purpose of minimising the total weighted sum of distances among all machine pairs. To reflect real manufacturing situations, a minimum space (so-called clearances) between machines may be required by observing technological constraints, safety considerations and regulations. This thesis intends to outline the different concepts of clearances used in literature and analyse their effects on modelling and solution approaches for the SRLP. In particular the special characteristics of sequence-dependent, asymmetric clearances are discussed and finally extended to large size clearances (machine-spanning clearances). For this, adjusted and novel model formulations and solution approaches are presented. Furthermore, a comprehensive survey of articles published in this research area since 2000 is provided which identify recent developments and emerging trends in SRLP.

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