Dissociation may be broadly described as a subjective experience in which information from the individual's internal or external environment is not appropriately integrated into conscious awareness, memory or identity. A number of studies have found an association between dissociative experience and anxious arousal, and in particular, between dissociation and trauma. Recent reviews suggest the existence of an unspecified mediating variable that accounts for these associations. The present study compared dissociative experiences reported by a community sample (N = 74) and a sample of individuals with a range of anxiety disorders (N = 20). The potential influence of anxiety sensitivity was a particular focus. Participants completed a battery of measures assessing dissociative experience, anxious arousal, social anxiety, generalised anxiety, panic and agoraphobia, traumatic experience and posttraumatic stress in addition to measures of anxiety sensitivity and substance use. Participants in the anxiety group reported a greater variety and frequency of dissociative experiences, particularly of experiences considered to be pathological in nature. Elevated dissociation scores were associated with somatic symptoms of anxiety, social anxiety, generalised anxiety, agoraphobia and posttraumatic stress. No association between trauma exposure and dissociation was evident; however, trauma intensity was associated with dissociation in the anxiety group. Symptoms of depersonalisation / derealisation and absorption were most strongly associated with increased anxiety. Anxiety Sensitivity accounted for more of the variance in dissociation scores than did measures of expressed anxiety. These results suggest that anxiety sensitivity may account for the relationship between trauma anxiety and dissociation. Therapeutic intervention directed at anxiety sensitivity, particularly fear of cognitive discontrol, may prove helpful in treating dissociative detachment.

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Assuming a set of variates are independent and normally distributed is commonplace in statistics. In this thesis, we consider the consequences of these assumptions as they pertain to global sensitivity analysis. We begin by illustrating how the notion of sensitivity becomes distorted in the presence of codependent model inputs. This observation motivates us to develop a new methodology which accommodates for input codependencies. Our methodology can be summarized through three points: First, a new form of sensitivity is presented which performs as well as the classical form but can be obtained at a fraction of the computational cost. Second, we define a measure which quantifies the extent of distortion caused by codependent inputs. The third point is regarding the modelling of said codependencies. The multivariate normal distribution is a natural choice for modelling codependent inputs; however, our methodology uses a copula-based approach instead. Copulas are a contemporary strategy for constructing multivariate distributions whereby the marginal and joint behaviours are treated separately. As a result, a practitioner has more flexibility when modelling inputs. / Thesis (Master, Chemical Engineering) -- Queen's University, 2013-12-05 10:16:26.81

The LHCb experiment (CERN) will offer a precise hadronic probe with which to study CP violation, rare decays and possible New Physics (NP) effects occurring in the b-system. Contained within the vast physics program is a dedicated and intense effort to measure the CP violating weak mixing phase, βs. This phase, observable in the neutral Bs-system, presents a sensitive indicator to NP occurring at the TeV scale. This phase appearing through the theoretically clean ¯b → ¯cc¯s quarklevel transition, can be measured precisely using Bs → J/ψφ decays. The analysis of Bs → J/ψφ decays requires using its decay angular information to separate out the CP eigenstates. The sensitivity to βs can then be extracted from the angular differential rates for this mode. This thesis presents the selection and reconstruction of this decay channel, analysis of the background specific to this channel and the method for fitting the data to extract βs. Previous studies within the collaboration have shown the βs sensitivity using a reduced angular expression for the decay rates. By studying the full angular expression, we find both a quantitative and qualitative improvement in the precision with which βs is obtained: the precision improves by approximately 20%, from ± 0.027 to ± 0.022 radians. In addition, we find it is possible to extract the b-tagging parameter from data itself, which aids to minimise the overall systematic effect. This thesis, in preparation for data taking at the LHCb, presents this expected improvement in measuring βs.

UA Open Access Publishing Fund / Background Missing outcome data is a threat to the validity of treatment effect estimates in randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity analysis of missing data and intention-to-treat (ITT) analysis of randomized controlled trials (RCTs) in top tier medical journals, and compare our findings with previous reviews related to missing data and ITT in RCTs. Methods Review of RCTs published between July and December 2013 in the BMJ, JAMA, Lancet, and New England Journal of Medicine, excluding cluster randomized trials and trials whose primary outcome was survival. Results Of the 77 identified eligible articles, 73 (95%) reported some missing outcome data. The median percentage of participants with a missing outcome was 9% (range 0 – 70%). The most commonly used method to handle missing data in the primary analysis was complete case analysis (33, 45%), while 20 (27%) performed simple imputation, 15 (19%) used model based methods, and 6 (8%) used multiple imputation. 27 (35%) trials with missing data reported a sensitivity analysis. However, most did not alter the assumptions of missing data from the primary analysis. Reports of ITT or modified ITT were found in 52 (85%) trials, with 21 (40%) of them including all randomized participants. A comparison to a review of trials reported in 2001 showed that missing data rates and approaches are similar, but the use of the term ITT has increased, as has the report of sensitivity analysis. Conclusions Missing outcome data continues to be a common problem in RCTs. Definitions of the ITT approach remain inconsistent across trials. A large gap is apparent between statistical methods research related to missing data and use of these methods in application settings, including RCTs in top medical journals.

CD8+ T-cell antigen sensitivity is critical for optimal control of persistent viral infections, including HIV-1. The devastating HIV-1 pandemic may be countered by development of a cytotoxic T lymphocyte based vaccine if qualities associated with protection can be defined at the molecular level. However, the heterogeneity of the total viral-specific CTL response confounds identification of protective correlates and T-cell sensitivity is no exception and remains controversial. To address this issue we reduced the heterogeneity of the HIV-1 CTL response to single units, generating 19 CTL clones that recognise the same HIV-1 derived epitope restricted by HLA B*08. Correlation of functional assays directly with the ability of each clone to control HIV-1 replication in vitro, the “viral suppression assay,” identified antigen sensitivity as a key quality for anti-viral efficacy. Remarkably, four clones from this panel, isolated from one individual, a long-term non-progressor, all used an identical TCR yet had distinct antigen sensitivity and suppressive activity. Two of these clones were characterised in detail, and had distinct cytokine profiles, regulated by epigenetic mechanisms, and differential expression of a group of cell surface receptors with the potential to modulate the signalling threshold to antigen. Expression of the TNFα locus of the high sensitivity clone with “Good” suppression was repressed by DNA methylation. Understanding how CTL qualities required for optimal control of HIV-1 replication differentiate and are then enriched in the total CTL response, and if repression of TNFα contributes to this process, will contribute to rational vaccine design. This is the first evidence that avidity maturation in CD8+ T cells with the same TCR affinity occurs in viral infections in humans as reported in the mouse. This suggests the induction of high sensitivity CTL will be critical for an effective HIV-1 vaccine, but offers hope that this can be achieved even in individuals without protective HLA alleles, by further exploration of peripheral avidity maturation and epigenetic regulation of the HIV-1 specific CD8+ T-cell response.

Retinal blur experienced by myopes during near work has been linked to myopia development and progression. Whether poor responses to blur signals are due to poor perceptual blur sensitivity (subjective depth of focus), poor neural accommodation responses (objective depth of focus) to blur or optical differences such as higher order aberrations making blur detection difficult is yet unclear. This study investigates whether myopes respond to blur differently compared to emmetropes and whether filtering spatial frequencies in reading text influence accommodation responses. Accommodative functions were investigated using spatial frequency filtered text targets of two different sizes (N10 and N20). Monocular objective depth of focus (DOF), accommodative microfluctuations, and dynamic accommodation were measured. Subjective DOF after cycloplegia was also recorded with the same targets. Higher order aberration measurements explored optical contributions to blur. Peripheral refraction and accommodative lag were also measured to consider how in combination they might increase peripheral retinal blur for near tasks. Results showed that myopes demonstrated larger subjective DOF. Subjective DOF was larger when viewing the peak text spatial frequency in both refractive error groups. The optimum focus was more myopic for text peak spatial frequencies. Levels of spherical aberration were correlated with the point of optimum focus. Objective DOF and accommodative microfluctuations were larger in myopes when viewing the peak text spatial frequencies. Dynamic accommodation showed that while myopes were not poorer at initiating accommodation responses they had longer positive response times. Accommodative lag, although not different in myopes, increases the peripheral hyperopic blur experienced for near tasks. Conclusion: Myopes were poorer at using retinal blur cues to refine accommodation responses especially when viewing peak text spatial frequencies. Larger positive response times, DOF and accommodative microfluctuations in myopes resulted in accommodative error and hyperopic blur for near tasks. Spherical aberration, previously thought to provide a myopigenic stimulus, was not different between refractive groups and is unlikely to be large enough to enhance DOF during naturalistic viewing. Blur adaptation studies might consider using peak text spatial frequencies as adaptation targets to reduce accommodation differences in myopes and emmetropes. Optical treatment strategies aimed at correcting peripheral refraction to control myopia should consider the combined effect of accommodative lag which increases levels of hyperopic peripheral blur experienced by myopes.

The present study is an evaluation of music appreciation courses in selected institutions of higher learning by measuring change in the sensitivity of the students to form and style in unfamiliar music.

Abstract The aim of this study was to determine whether maternal sensitivity acts as a mediator in the associations between a mother‟s childhood history of care and her child‟s emotion regulation and attachment security at 2 ½ years of age. It was hypothesized that children of mothers who perceived their own childhood experiences with parents as caring and accepting would display more adaptive regulatory behaviors in fear-eliciting contexts and be more securely attached than children of mothers who recollected rejection in their own childhood experiences, with maternal sensitivity mediating these associations. Participants were 82 toddlers and their mothers. Mothers rated their childhood experiences of care and acceptance with their own parents prior to the laboratory procedure. Each child was presented with four novel stimuli, with mothers present, but not involved for the first two tasks and involved in the remaining two. Presentation of the novel stimuli was in pairs including one toy task (i.e., monster or robot) and one person task (i.e., clown or masks). Children‟s emotion regulation behaviors were coded continuously during the mother not involved condition, whereas observed maternal sensitivity was rated in the mother involved condition. Information about maternal sensitivity and children‟s attachment behaviors was reported by mothers using a diary technique. A path analysis was used to test the model examining the relationship between maternal history of care and sensitivity and children‟s attachment security and emotion regulation behaviors (i.e., distraction, withdrawal, contact with mother). Maternal sensitivity mediated the association between a mother‟s childhood history of care and acceptance and child attachment. Post-hoc analysis showed that this conditional indirect effect was significant only for children of mothers with less than a complete college education. In contrast, a childhood history of care and acceptance did not predict children‟s emotional regulation behaviors, although it interacted with education to predict distraction. Maternal sensitivity was associated positively with distraction and negatively with withdrawal, whereas children‟s attachment security was not associated with any emotion regulation behavior. Results are discussed in relation to attachment theory and continuities and discontinuities in the transmission process in mother-child relationships.