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Ionization and solubility.Pearce, William Tudor. January 1900 (has links)
Thesis (Ph. D.)--University of Chicago, 1916. / "A Private edition distributed by the University of Chicago libraries." "Reprinted from the Journal of the American Chemical Society, vol. 38, no. 12, December, 1916." Includes bibliographical references.
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Molecular basis of the low-temperature insolubility of monoclonal cryoimmunoglobulins /Middaugh, Charles Russell. January 1978 (has links)
Thesis (Ph. D.)--Cornell University, 1978. / Vita. Includes bibliographical references.
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Solubility relations of sugars and related compounds. I. Solubility of d-mannose, [alpha]-methyl mannoside, d-mannitol, rhamnose and d-mannonic [gamma]-lactone, in various liquids,Fluevog, Edwin A., January 1900 (has links)
Thesis (PH. D.)--University of Nebraska, 1930. / Bibliography: p. 24.
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A study of the solvent effect on the iodination of olefinsGeerts, Marcellus Joseph. January 1939 (has links)
Thesis (Ph. D.)--University of Notre Dame, August 1939. / Bibliography, p. 42-43.
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Moisture sorption kinetics for water-soluble substancesVan Campen, Lynn. January 1981 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1981. / Typescript. Vita. Description based on print version record. Includes bibliographical references (leaves 181-185).
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The solubility of liquids in liquids The partition of the lower acids between water and cottonseed oil. Also the partition of formic acid between water and various organic compounds ...Gordon, Neil Elbridge, January 1922 (has links)
Thesis (Ph. D.)--Johns Hopkins University, 1917. / Biography.
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Solubility relations of sugars and related compounds. I. Solubility of d-mannose, a-methyl mannoside, d-mannitol, rhamnose and d-mannonic y-lactone, in various liquids,Fluevog, Edwin A., January 1930 (has links)
Thesis (PH. D.)--University of Nebraska, 1930. / Description based on print version record. Bibliography: p. 24.
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Dissolution behavior of crystalline solvated and nonsolvated forms of some pharmaceuticalsShefter, Eli. January 1963 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1963. / Typescript. Abstracted in Dissertation abstracts, v. 23 (1963) no. 9, p. 3325-26. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 68-69).
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The influence of salts on the solubility of other salts in nonaqueous solvents,Seward, Ralph Pray. January 1900 (has links)
Thesis (Ph. D.)--Brown University, 1925.
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The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution / Influence of a methylated-B-Cyclodextrin on the solubility and photostability of midazolam in aqueous solutionLebete, Mosimotsana Leah 26 April 2013 (has links)
Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a solubilizer. / KMBT_363 / Adobe Acrobat 9.53 Paper Capture Plug-in
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