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Adaptation and Clinical Validation of a New Handheld Optical Imaging Device (PRODIGI™) and Workflow for Real-time Intra-operative Margin Assessment in Breast CancerWang, Jenny 27 November 2012 (has links)
Background: We report here early attempts of adapting a prototype fluorescence imaging system (PRODIGI™) to be used as a surgical guidance tool to improve margin-detection in breast cancer.
Methods: 36 patients were recruited to study the autofluorescence characteristics of ex vivo specimens. 5-ALA (20 mg/kg) was used as a contrast agent in human breast cancer cell lines and xenograft tumour models to detect PpIX fluorescence.
Results: Administrative approvals were obtained and a surgical drape was used for sterilization. PRODIGITM could differentiate between normal and tumour tissues based on autofluorescence alone in ex vivo samples. PpIX signal was detected in experimental mice, and absent in control mice. The threshold of detection was on the order of 10 nM.
Conclusions: Autofluorescence alone with PRODIGI™ was not sufficient for margin assessment of ex vivo breast tumour surgical specimens. 5-ALA at an optimal dosage may be adopted as a contrast agent to enhance tumour signal.
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Adaptation and Clinical Validation of a New Handheld Optical Imaging Device (PRODIGI™) and Workflow for Real-time Intra-operative Margin Assessment in Breast CancerWang, Jenny 27 November 2012 (has links)
Background: We report here early attempts of adapting a prototype fluorescence imaging system (PRODIGI™) to be used as a surgical guidance tool to improve margin-detection in breast cancer.
Methods: 36 patients were recruited to study the autofluorescence characteristics of ex vivo specimens. 5-ALA (20 mg/kg) was used as a contrast agent in human breast cancer cell lines and xenograft tumour models to detect PpIX fluorescence.
Results: Administrative approvals were obtained and a surgical drape was used for sterilization. PRODIGITM could differentiate between normal and tumour tissues based on autofluorescence alone in ex vivo samples. PpIX signal was detected in experimental mice, and absent in control mice. The threshold of detection was on the order of 10 nM.
Conclusions: Autofluorescence alone with PRODIGI™ was not sufficient for margin assessment of ex vivo breast tumour surgical specimens. 5-ALA at an optimal dosage may be adopted as a contrast agent to enhance tumour signal.
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Reduction of microbial population of seafood by radiation pasteurizationEast, Dorothy May 20 April 1961 (has links)
Graduation date: 1961
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The effectiveness of health education on changing of knowledge, attitudes and adoption of post-partum sterilization /Pranee Soonthornsaduog. January 1984 (has links) (PDF)
Thesis (M.Sc. (Public Health))--Mahidol University, 1984.
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115 |
Perceptions of the experience of tubal ligation : an exploratory study in fertility control among twenty low income, black women.Butts, June Dobbs. January 1969 (has links)
Thesis (Ed.D.)--Teachers College, Columbia University. / Typescript; issued also on microfilm. Sponsor: Hope Leichter. Dissertation Committee: Gilbert H. Shimmel. Includes bibliographical references.
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Efficiency of LHRH immunization as a male sterilization vaccineHernandez, Jennifer A., January 2004 (has links) (PDF)
Thesis (Ph. D.)--Washington State University. / Includes bibliographical references.
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117 |
Changes of mechanical properties of hypodermic needles as influenced by disinfection, sterilization and use a thesis submitted in partial fulfillment ... /Cruz-Jasso, Horacio. January 1958 (has links)
Thesis (M.S.)--University of Michigan, 1958.
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118 |
Changes of mechanical properties of hypodermic needles as influenced by disinfection, sterilization and use a thesis submitted in partial fulfillment ... /Cruz-Jasso, Horacio. January 1958 (has links)
Thesis (M.S.)--University of Michigan, 1958.
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119 |
Asepsis und Antisepsis in der zahnärztlichen Praxis unter besonderer Berücksichtigung der Sterilisation des HandstückesDreher, Frida, January 1930 (has links)
Thesis (Doctoral)--Ludwig-Maximilians-Universität zu München, 1930.
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120 |
Asepsis und Antisepsis in der zahnärztlichen Praxis unter besonderer Berücksichtigung der Sterilisation des HandstückesDreher, Frida, January 1930 (has links)
Thesis (Doctoral)--Ludwig-Maximilians-Universität zu München, 1930.
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