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Purpose: Ultrasound is prevalent in image-guided therapy as a safe, inexpensive, and widely available imaging modality. However, extensive training in interpreting ultrasound images is essential for successful procedures. An open-source ultrasound image simulator was developed to facilitate the training of ultrasound-guided spinal intervention procedures, thereby eliminating the need for an ultrasound machine from the phantom-based training environment. Methods: Anatomical structures and surgical tools are converted to surface meshes for data compression. Anatomical data is converted from segmented volumetric images, while the geometry of surgical tools is available as a surface mesh. The pose of the objects are either constants or live measurements from a pose tracking device. Intersection points between the surface models and the ultrasound scan lines are determined with a binary space partitioning tree. The scan lines are divided into segments and filled with grey values determined by an intensity calculation accounting for material properties, reflection, and attenuation parameters defined in a configuration file. The scan lines are then converted to a regular brightness-mode ultrasound image. Results: The simulator was tested in a tracked ultrasound imaging system, with a mock transducer tracked by an Ascension TrakStar electromagnetic tracker, on a spine phantom. A mesh model of the spine was created from CT. The simulated ultrasound images were generated at a speed of 50 frames per second, and a resolution of 820 x 616 pixels on a PC with a 3.4 GHz processor. A human subject trial was conducted to compare the learning performance of novice trainees with real and simulated ultrasound in the localization of the facet joints of a spine phantom. With 22 participants split into two equal groups and each participant localizing 6 facet joints, there was no statistical difference in the performance of the two groups, indicating that simulated ultrasound could indeed replace the real ultrasound in phantom-based ultrasonography training for spinal interventions. Conclusion: The ultrasound simulator was implemented and integrated into the open-source Public Library for Ultrasound (www.plustoolkit.org) and SlicerIGT (www.SlicerIGT.org) toolkits / Thesis (Master, Computing) -- Queen's University, 2013-07-24 12:28:57.201

This thesis describes work carried out on the research, development and implementation of new processes for the fabrication of surface plasmon waveguide biosensors. Fabrication of surface plasmon resonance (SPR) based waveguides embedded in a thick CYTOP cladding with the incorporation of fluidic channels was achieved with improved quality and operability compared to previous attempts. The fabrication flow was modified in key areas including lithography for feature definition, gold evaporation and the upper cladding deposition procedure. The combined result yielded devices with sharper resolution of waveguides, gold surfaces with minimal aberrations, reduced surface roughness and minimization of waveguide deformation due to reduction of solvent diffusion into the lower cladding. The fabricated waveguides consisted of a thin, 35 nm, patterned gold film, embedded in a thick, 18 µm, CYTOP fluoroploymer cladding. The gold devices were exposed by O2 plasma etching through the upper cladding to form fluidic channels for the facilitation of flow of an index matched sensing medium. Optical and physical characterization of devices revealed structures of significantly improved quality over previous attempts, rendering the platform competitive for biosensing applications.

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