The PRESTO sequence is a well-known 3-D fMRI imaging sequence. In this sequence the echo planar imaging technique is merged with the echo-shift technique. This combination results in a very fast image acquisition, which is required for fMRI examinations of neural activation in the human brain. The aim of this work was to use the basic Cartesian PRESTO sequence as a framework when developing a novel trajectory using a non-Cartesian grid. Our new pulse sequence, PRESTO CAN, rotates the k-space profiles around the ky-axis in a non-Cartesian manner. This results in a high sampling density close to the centre of the k-space, and at the same time it provides sparser data collection of the part of the k-space that contains less useful information. This "can- or cylinder-like" pattern is expected to result in a much faster k-space acquisition without loosing important spatial information. A new reconstruction algorithm was also developed. The purpose was to be able to construct an image volume from data obtained using the novel PRESTO CAN sequence. This reconstruction algorithm was based on the gridding technique, and a Kaiser-Bessel window was also used in order to re-sample the data onto a Cartesian grid. This was required to make 3-D Fourier transformation possible. In addition, simulations were also performed in order to verify the function of the reconstruction algorithm. Furthermore, in vitro tests showed that the development of the PRESTO CAN sequence and the corresponding reconstruction algorithm were highly successful. In the future, the results can relatively easily be extended and generalized for in vivo investigations. In addition, there are numerous exciting possibilities for extending the basic techniques described in this thesis.

Cores, quarry exposures, and exploratory wells in the Paleogene Albemarle Basin, North Carolina sample the transition between the southern carbonate and northern siliciclastic provinces of the eastern U.S. continental shelf succession. The study area includes the relatively positive Cape Fear Arch on the Onslow Block to the south, and the slowly subsiding (1.5 cm/ky) Albemarle Block to the north. The Paleogene supersequence set boundary is a hardground on Cretaceous shoreface/shallow-shelf mollusk facies. It is overlain by a thin Paleocene sequence of deeper offshore, glauconitic fine sands to deep marine silt-shale. Five regionally mappable, vertically stacked Eocene sequences are 0 to 30 m thick and contain coastal sands, shoreface sandy-mollusk rudstones, offshore bryozoan grainstone-packstones and subwave base fine wackestone-packstone and marl. The Eocene sequences commonly are bounded by hardgrounds, overlain by thin local lowstand sands and consist of a thin transgressive unit (commonly absent), overlain by an upward shallowing highstand marine succession. On the arch, lowstand and transgressive units may be condensed into lags. The Lower Oligocene succession on the arch has a single marl to fine foram sand dominated sequence whereas downdip, two to three sequences are developed, capped by nearshore sandy molluscan facies. The Upper Oligocene is dominated by possibly three sequences composed of basal, thin sands up into variably sandy mollusk rudstone. Sequence development was influenced by differential movement of the basement blocks, coupled with increasing 3rd order eustatic sea level changes during global cooling. This was coupled with swell-wave and current sweeping of the shelf that effectively decreased available accommodation by 20 to 30 m, and generated the distinctive hardgrounds on sequence boundaries, and variable development of lowstand and transgressive system tracts. The well developed highstands reflect maximum accommodation allowing deposition of an upward shallowing succession that terminated at the depth of wave abrasion on the open shelf. The sequence stratigraphic development contrasts markedly with that from tropical shelves. / Master of Science

Architectural and urban design for the reconversion of the part of the Old Brno (former textil fabric of the company Kras and surrounding areas) based on the existing structure of the Old Brno and ideas of compact city (mixing functions> multipurpose buildings, the divergence between private and public space, higher density of the city ...) The work consists of several parts: planning studies, design transportation solutions, waterfront Svratka concept and design for the multifunctional block on the waterfront. What is important is the idea of calming waterfront Svratka (sheltering services to the proposed tunnel and the cancellation of barrier between the city and the river). The waterfront district should become after more attractive location and provide a space for sport, recreation and afternoon walks. There is a block of multipurpose buildings on the waterfront. A corporate underground garage, which is under the block, should be build by a strong investor / city. After underground garage completion, the site will be divided into several parcels and these will be rented to various long-term investors .Tenants can build buildings on them according to their needs. It is possible to build buildings above the garage in sequence development. The project is just one of many options. Individual buildings are design in scale 1:200

The Miocene of the Lidam area, Eastern Province, Saudi Arabia, was studied to examine the interaction of glacio-esustasy during moderate Antarctic glaciation, within a small back bulge basin on the slowly subsiding distal Arabian foreland, distal from the active Zagros fold-thrust belt. Low subsidence rates of 1 to 4 cm/k.y generated the long-term accommodation, which were considerable slower than those in the proximal foredeep in Iran. Deposition of the siliciclastics was driven by lowered sea levels, and moderately humid to arid climate. Rising sea levels pushed the siliciclastics updip allowing mixed siliciclastics and carbonates to form downdip, under semi-arid climate and locally hypersaline conditions. Maximum transgression slightly predated the Middle Miocene climatic optimum when prograding siliciclastics migrated across the platform. Falling triggered siliciclastic deposition under semi-arid climate. Sequences appear to relate to long-term obliquity (~1.2 m.y. cycles) and long-term eccentricity (400 k.y.) cycles. The succession contains numerous missing beats reflecting the updip position of the study area, and sea level changes of tens of meters that frequently exposed the platform. Siliciclastic units commonly are incised into muddy sediments beneath sequence boundaries. Multiple exposure surfaces occur within Hadrukh brecciated palustrine carbonates. Within Dam carbonates, parasequence boundaries commonly are capped by tidal flat laminites (some of which are incipiently brecciated). High frequency negative excursions of ∂¹³C within the succession appear to relate to near-surface diagenesis by soil gas depleted in ∂¹³C beneath sequence boundaries. Positive C isotope excursions in the Lidam Miocene section can be tied to similar excursions in Qatar and UAE, where Sr isotope dates constrain the ages of the units. The overall C isotope profile at Lidam shows depleted values early in the Miocene to heavy values in the Middle Miocene, becoming lighter again in the late Miocene. The profile appears to follow the long-term global ∂¹³C curve. Incursion of meteoric groundwaters into the study area was driven by the long-term global sea level changes. Oxygen isotopes are surprisingly light, extending down to -12.5 ‰VPDB. The very light δ¹⁸O values of the meteoric waters may be explained by rainfall associated with enhanced Miocene Indian monsoons, and with far travelled air mass trajectories migrating across north Africa and from the polar region. / Ph. D.

Collateral blood flow is the compensatory flow of blood to the tissue through secondary channels when the primary channel is compromised. It is of vital importance in cerebrovascular disease where collateral flow can maintain large regions of brain tissue which would otherwise have suffered ischaemic damage. Traditional x-ray based techniques for visualising collateral flow are invasive and carry risks to the patient. In this thesis novel magnetic resonance imaging techniques for performing vessel-selective labelling of brain feeding arteries are explored and developed to reveal the source and extent of collateral flow in the brain non-invasively and without the use of contrast agents. Vessel-encoded pseudo-continuous arterial spin labelling (VEPCASL) allows the selective labelling of blood water in different combinations of brain feeding arteries that can be combined in post-processing to yield vascular territory maps. The mechanism of VEPCASL was elucidated and optimised through simulations of the Bloch equations and phantom experiments, including its sensitivity to sequence parameters, blood velocity and off-resonance effects. An implementation of the VEPCASL pulse sequence using an echo-planar imaging (EPI) readout was applied in healthy volunteers to enable optimisation of the post-labelling delay and choice of labelling plane position. Improvements to the signal-to-noise ratio (SNR) and motion-sensitivity were made through the addition of background suppression pulses and a partial-Fourier scheme. Experiments using a three-dimensional gradient and spin echo (3D-GRASE) readout were somewhat compromised by significant blurring in the slice direction, but showed potential for future work with a high SNR and reduced dropout artefacts. The VEPCASL preparation was also applied to a dynamic 2D angiographic readout, allowing direct visualisation of collateral blood flow in the brain as well as a morphological and functional assessment of the major cerebral arteries. The application of a balanced steady-state free precession (bSSFP) readout significantly increased the acquisition efficiency, allowing the generation of dynamic 3D vessel-selective angiograms. A theoretical model of the dynamic angiographic signal was also derived, allowing quantification of blood flow through specified vessels, providing a significant advantage over qualitative x-ray based methods. Finally, these methods were applied to a number of patient groups, including those with vertebro-basilar disease, carotid stenosis and arteriovenous malformation. These preliminary studies demonstrate that useful clinical information regarding collateral blood flow can be obtained with these techniques.