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On the biosynthesis and processing of cathepsin G, leukocyte elactase, and azurocidin neutrophil granule members of a hematopoietic serine protease superfamily /Lindmark, Anders. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.
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On the biosynthesis and processing of cathepsin G, leukocyte elactase, and azurocidin neutrophil granule members of a hematopoietic serine protease superfamily /Lindmark, Anders. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.
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Regulation of human oviductin mRNA expression. / CUHK electronic theses & dissertations collectionJanuary 2002 (has links)
Christine May Briton-Jones. / "May 2002." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 149-171). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.
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Role of tripeptidyl peptidase II in cell cycle regulation and tumor progression /Stavropoulou, Vaia, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 3 uppsatser.
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Etude sur la synthèse totale du cyclothéonamide CRoche, Stéphane 13 February 2006 (has links) (PDF)
L'objectif était d'effectuer la première synthèse total de Cyclothéonamide C (CTC), un pentapeptide macrocyclique, inhibiteur puissant des sérine protéases. Il a plusieurs motifs structuraux uniques, comprenant un vinylogue de déshydrotyrosine (V-deltaTyr) et une alpha-Cétohomoarginine (K-Arg). Le plus grand défi résidait à créer le résidu K-Arg ou un précurseur approprié alpha-Hydroxyhomoarginine (H-Arg) dans des intermédiaires peptidiques avancés. On propose trois stratégies différentes pour y parvenir : "Passerini-Acyl Migration" (PAM), "Masked Acyl Cyanide" (MAC) et "alpha-Keto-Acyl Cyanide" (KAC) . Une préparation préalable de peptides électrophiles et nucléophiles (aldéhydes et alpha-cétocyanophosphoranes ; amines et isonitiles) est nécessaire pour l'exécution des différentes stratégies. Les trois stratégies sont alors développées pour fournir des pentapeptides linéaires transformés ensuite en macrocycliques. Les étapes de déprotection et d'oxydation finissent formellement la synthèse de CTC
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The role of TPPII in apoptosis control and treatment of malignant disease /Xu, Hong, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.
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Serina endopeptidases de insetos e a interação inseto-planta / Insect serine-endopeptidases and plant-insect interactionsLopes, Adriana Rios 03 May 2004 (has links)
Serina endopeptidases de insetos, principalmente tripsinas e quimotripsinas, estão envolvidas na digestão inicial de proteínas. Genes codificadores para estas enzimas estão organizados em famílias multigênicas tendo expressão diferencial de acordo com a dieta do inseto, estando envolvidos no desenvolvimento de resistência a diferentes metabólitos secundários vegetais. Para uma melhor compreensão desta interação, fez-se necessário o isolamento destas enzimas para insetos de diferentes ordens, bem como a caracterização de suas especificidades por duas abordagens: (a) caracterização cinética dos subsítios componentes do sítio de ligação de tripsinas e quimotripsinas, utilizando diferentes substratos, modificadores químicos e inibidores e (b) estudos estruturais por modelagem molecular, clonagem, expressão e cristalização destas enzimas de insetos. Além disso, estudos evolutivos por análise de distância possibilitaram uma caracterização inicial da interação insetoplanta. Estas determinações permitiram verificar que tripsinas de insetos apresentam diferenças de especificidade tanto dentre as diferentes ordens de insetos quanto em relação às tripsinas de vertebrados, sendo que as tripsinas da ordem Lepidóptera apresentam troca de especificidade primária hidrolisando preferencialmente substratos P1 Lys. Foram também observadas diferenças de hidrofobicidade para os subsítios caracterizados sendo que estes apresentam hidrofobicidades crescentes segundo o grau de complexidade dos insetos na sua escala evolutiva. A troca de especificidade e o aumento da hidrofobicidade podem permitir a hidrólise dos inibidores vegetais protéicos. A análise das sequências de tripsinas de insetos por Neighbor Joining (NJ) compõe uma árvore de distâncias topologicamente semelhante à árvore de relações filogenéticas determinadas por morfologia. A sobreposição de estruturas pré -determinadas de tripsina complexada a diferentes inibidores permite a identificação de posições de interação enzima-inibidor que justificam a classificação em grupos distintos de enzimas sensíveis ou resistentes a presença de inibidores na dieta de insetos. Da mesma forma: a caracterização da especificidade das quimotripsinas de insetos permitiu a separação de grupos distintos de quimotripsinas. Estes grupos são sustentados pela substituição do resíduo 59 em insetos polífagos que alimentam-se de plantas que contêm cetonas naturais reativas. Estas caracterizações demonstram a importância de um estudo detalhado da especificidade de serina endopeptidases possibilitando o desenho de moléculas apropriadas para inibição destas e desenvolvimento de estratégias de controle de insetos. / Insect serine endopeptidases, mairily trypsin and chymotrypsin are involved in initial protein digestion. Genes that encode these proteins are members of complex multigene families and are differentially expressed according to insects diet , thus being involved with resistance to plant metabolites. Purification of trypsins from different insect orders and chymotrypsins, as well as, characterization of their specificity are essential to a better understanding of this interaction. Characterization relied on two approaches: (a) kinetic characterization of the binding subsities of trypsins and chymotrypsins using different substrates, chemical modification and inhibition assays and (b) study of protein structure by molecular modelling and cloning, expression and crystallization of these enzymes. Besides that, evolutionary studies performed through distance analysis, permitted the investigation of plantinsect interaction. These characterizations showed that insect trypsins, in terms of specificity, are quite different from vertebrate trypsins and among insect orders. Lepidopterans trypsins have a distinct primary specificity, since they hydrolyses preferentially P1 Lys substrates, and present a crescent subsite hydrophobicity, which is directly correlated with the evolutionary scale. Both, the specificity exchange and the crescent hydrophobicity can allow the hydrolysis of vegetal proteic inhibitors. The analysis of trypsin sequences in Neighbor-Joining (NJ) algorithm yield a distance tree that is coherent with morphological phylogenetic relationships. The superposition of predicted structures of trypsins-inhibitors complexes permits to observe amino acid residues of interaction between enzyme-inhibitor, which support the distinction of different groups between sensitive and insensitive trypsins to the presence of inhibitors on insect diet. Similarly, characterization of insect chymotrypsins according to their specificity allowed us to classify these enzymes into different groups. These groups are supported by residue 59 replacements in polyphagous insects, which feed on plants bearing natural reactive ketones. These studies show the irnportance of a detailed study of serine endopeptidases, which may help in the development of better insect control strategies.
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Mechanism of age-related macular degeneration: the role of HtrA1 and related molecules. / CUHK electronic theses & dissertations collectionJanuary 2010 (has links)
Ng, Tsz Kin. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 151-185). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.
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Molecular genetics of proteases of Porphyromonas gingivalis W83Lewis, Janina Pawlowska, January 1997 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 1997. / Prepared for: Dept. of Microbiology and Immunology. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Molecular genetics of proteases of Porphyromonas gingivalis W83Lewis, Janina Pawlowska, January 1997 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 1997. / Prepared for: Dept. of Microbiology and Immunology. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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