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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
51

Induction of L-arginine transport and nitric oxide synthase by pro-inflammatory cytokines and bacterial lipopolysaccharide in vascular smooth muscle cells

Wileman, Samantha Mary January 1996 (has links)
No description available.
52

The application of Transient Statistical Energy Analysis and wave propagation approach to coupled structures

Lednik, Dusan January 1994 (has links)
No description available.
53

The role of the mitochondrial HSP70 in plant growth and development

Dudley, Penelope January 1997 (has links)
No description available.
54

Characterisation of the heat shock response in Streptomyces lividans

Barratt, Elizabeth M. January 1993 (has links)
No description available.
55

Particle cascades in quasar central engines

Begley, Alison Margaret January 2002 (has links)
No description available.
56

Effects of endotoxin on cationic amino acid transport in peripheral blood mononuclear cells

Clark, Megan Frances January 1998 (has links)
No description available.
57

A study of the circulatory responses to fever with and without hypertension

Weinberg, Julius Rolf January 1989 (has links)
No description available.
58

Cardiovascular regulatory mechanisms in endotoxaemia

Waller, John January 1996 (has links)
No description available.
59

Characterisation of a HSP70 gene in Aspergillus nidulans

Newbury, Jane Amanda January 1994 (has links)
No description available.
60

Hsp72 translocation and secretion in in vivo and in vitro models

Leoni, Francesca January 2009 (has links)
Evidence suggesting that Hsp72 is actively participating in cellular signalling as well interacting with immune system dynamics has been increasing. This is true in healthy, stressed and diseased cells but to different degrees. Modulation of the plasma membrane association and secretion in the extracellular environment by different types of stressors is the key event that leads to different degrees of immune system activation. Hence a better understanding of the mechanisms of Hsp72 secretion and association with plasma membrane is crucial. This thesis investigated the tissue source and mechanism of Hsp72 surface presentation to plasma membrane structures and release in relation with different cellular and physiological stressors. In vivo models confirmed that different tissue types determine specific Hsp72 responses following the same stress and increase serum Hsp72 dependant on intensity and duration of the stress. Diseases models confirm that Hsp72 responses in specific cell populations is related to disease progression, while in vitro models clearly showed that there are multiple mechanisms of secretion and surface presentation, dependent on the nature of the stressor as well as the intensity and duration. This observations clearly change the view of extracellular Hsp72 as a danger signal and lead to a revision of the original danger model. It also suggests that manipulation of Hsp72 translocation through the different pathways involved may prove effective therapeutically.

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