Global ETD Search

11	Neuropsychological functioning in preschool-aged children with sickle cell disease : the role of illness-related and psychosocial factors / Tarazi, Reem A. January 2004 (has links) Thesis (Ph. D.)--Drexel University, 2004. / Includes abstract and vita. Includes bibliographical references (leaves 106-117).
12	Investigating cis- and trans-acting elements involved in regulating fetal hemoglobin gene expression using high throughput genetic data Shaikho Elhaj Mohammed, Elmutaz 27 November 2018 (has links) Sickle cell anemia is caused by a single mutation in the β-hemoglobin gene, HBB. The disease originated in Africa and affects millions of people worldwide. Sickle hemoglobin tetramers polymerize upon deoxygenation and lead to hemolysis and vaso-occlusion. Patients with high fetal hemoglobin (HbF) can have milder disease. The only FDA-approved drug is hydroxyurea that increases HbF. HbF modulates the disease by preventing the polymerization of sickle hemoglobin and reduces the pain episodes, anemia, and organ damage associated with the disease. There are five common haplotypes associated with the HbS gene and that are very loosely associated with disease severity and HbF. Understanding the genetic bases of HbF regulation is a key factor to identify potential drug targets to induce HbF for therapeutic purposes. To fully understand the mechanism behind HbF regulation, developing a fast and accurate computational method for sickle cell haplotype classification is useful for examining the variability of HbF among sickle cell patients. Moreover, investigating the cis and trans-acting regulators of HbF gene expression to pinpoint the mechanism through which they regulate HbF is essential to develop a successful treatment. The availability of high-throughput genetic data provides an excellent opportunity to study HbF regulation in sickle cell patients and normal people comprehensively. The work reported in this thesis describes a fast and accurate method for sickle cell HBB haplotype classification. I also examine the differential effect of cis and trans-acting HbF hemoglobin regulators on -globin gene expression using the GTEx database and identify BCL2L1 as a new potential trans-regulator of HbF. Bioinformatics BCL2L1 Fetal hemoglobin Sickle cell anemia
13	Phosphatidylserine exposure in red blood cells from patients with sickle cell disease Cytlak, Urszula Malgorzata January 2015 (has links) No description available. 636.089
14	The possible selection of the sickle cell trait in early homo Jefferson, Kellei Latham. Falk, Dean. January 2004 (has links) Thesis (M.S.)--Florida State University, 2004. / Advisor: Dr. Dean Falk, Florida State University, College of Arts and Sciences, Dept. of Anthropology. Title and description from dissertation home page (viewed June 21, 2004). Includes bibliographical references.
15	The mechanism and frequency of sickling of red blood cells in deer Kolb, Melita Margaret, 1940- January 1966 (has links) No description available. Erythrocyte disorders. Deer -- Diseases. Sickle cell anemia.
16	In vitro studies of intercellular interactions with pulmonary microvascular endothelium : involvement of cell adhesion, inflammatory mediators, and endothelial injury in sickle cell-related acute pulmonary complications Siano, James P. 05 1900 (has links) No description available. Sickle cell anemia Pulmonary endothelium Cell adhesion
17	Analysis of sickle erythrocyte adherence to endothelium in confined flow channels McNaull, Stewart A. 08 1900 (has links) No description available. Sickle cell anemia Erythrocytes Endothelium Vascular endothelium
18	Physico-chemical modulation of sickle adherence : a different in vitro model Montes, Richard Anthony O. 05 1900 (has links) No description available. Sickle cell anemia Erythrocytes Cell adhesion
19	Influence of sickle erythrocytes on arterial endothelial elongation and alignment in response to shear stress Sherrill, Amy Whiteman 08 1900 (has links) No description available. Erythrocytes Sickle cell anemia Vascular endothelium
20	Sickle cell-endothelial interactions : modulation of cell adhesion molecule expression Brown, Marena Dessette 12 1900 (has links) No description available. Sickle cell anemia Endothelium Vascular endothelium

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