The purpose of the study has been primarily to draw a profile of malignant melanoma in the different population groups inhabiting the Natal Province and Kwa-Zulu, to compare the presentation and incidence of the disease between these groups as well as with similar racial groups in different countries. The data collected then permitted to estimate which parameters were relevant in predicting the course of the disease, as well as the results of surgical and adjuvant therapy, and was utilized in a search for the aetiology of the tumour. / Thesis (M.D.)-University of Natal, Durban, 1985.

Thesis (Ph.D.) - University of Queensland, 2003. / Includes bibliography.

Thesis (MS)--Montana State University--Bozeman, 2008. / Typescript. Chairperson, Graduate Committee: David L. Dickensheets. Includes bibliographical references (leaves 69-70).

Thesis (M.Phil.) - University of Queensland, 2003. / Includes bibliography.

The research presented here considers automatic diagnosis support for skin cancer. The role of computer-based diagnosis, and its value within a primary care situation are examined resulting in synthesis of aims, requirements and properties for an effective system -a system based on digital optical images captured and processed using low-cost commercial computer technology. The issues involved in acquisition of lesion boundaries are discussed. The value of accurate and robust boundaries, in terms of both directly obtainable diagnostic features and in enabling lesion property evaluation, is identified. Previous research has proposed the edge focusing process. This work has addressed the improvement, in terms of potential for future development, evaluation and reuse, of this process through porting it to a highly modular form in the Khoros environment. The role of colour analysis and its value in terms of provision of diagnostically useful features is investigated, and the central importance of segmentation is identified. The fundamental properties of effective segmentation of lesion image colours are identified as a need to reflect human perception of colour similarity and a basis on local regions. A new region-based segmentation technique using data transformed to a perception-uniform colour-space is presented and shown to yield promising results. Finally the use of texture information is discussed. The nature and properties of the large-scale texture of skin patterning and its disruption are investigated and an abstracted representation proposed. A new technique is presented and shown to be effective in extracting the qualities of the skin patterning. Methods for analysing this representation of the patterning to quantify the disruption attributable to the lesion are proposed and developed. The combination of these extraction, analysis and disruption evaluation techniques is shown to be effective in relation to both visual assessment of disruption and diagnostic performance.

Made available in DSpace on 2014-06-11T19:24:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-17Bitstream added on 2014-06-13T19:48:18Z : No. of bitstreams: 1 zambrano_vf_me_arafcf.pdf: 924377 bytes, checksum: a7e1fa08a4f4d40ea755014baa9b09cd (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Universidade Estadual Paulista (UNESP) / A incidência do câncer de pele vem aumentando anualmente em homens e em mulheres, tornando-se grave problema se Saúde Pública mundial. Diversos são os fatores que influenciam a formação dos tumores, sendo a radiação ultravioleta um dos principais responsáveis, que vem elevando seu índice graças à redução da camada de ozônio. Ainda assim o câncer de pele poderia ser evitado se as medidas de prevenção fossem tomadas a tempo, como a fotoproteção, cuidados com os horários de exposição ao sol e a detecção precoce dos tumores. Os avanços científicos e tecnológicos têm proporcionado novas abordagens para o desenvolvimento de agentes antineoplásicos e o direcionamento de fármacos a locais de ação específicos, gerando maior eficácia dos tratamentos. Nesta linha, a principal proposta deste trabalho envolve a possibilidade de conjugar as propriedades do fotoprotetor salicilato de octila com a do antineoplásico 5-fluoruracila, por meio do processo de latenciação. Para tanto foi obtido o pró-fármaco succinil octil salicilato de 5- fluoruracila (SOSFlu), a partir de duas etapas sintéticas, cujos compostos foram caracterizados por meio da determinação da faixa de fusão, cromatografia em camada delgada, análises espectroscópicas de infravermelho, de ressonância magnética nuclear de 13C e 1H, determinação dos coeficientes de extinção molar e de partição. Tendo o SOSFlu apresentado melhores valores de coeficientes de extinção molar e de partição em relação ao fotoprotetor salicilato de octila e ao antineoplásico 5-fluoruracila, espera-se que apresente maior efetividade para proteger a pele contra a radiação ultravioleta e maior permeabilidade cutânea. / The incidence of the skin cancer comes increasing annually in men and in women, becoming a serious problem if world Public Health. Several they are the factors that influence the formation of the tumors, being the ultraviolet radiation responsible one of the main ones that comes elevating its index thanks to the reduction of the layer of ozone. Nevertheless the skin cancer could be avoided the prevention measures they were taken on time, as the sunscreem, cares with the schedules of exhibition in the sun and the precocious detection of the tumors. The scientific and technological progresses have been providing new bording for the development of agents antineoplasic and the drug delivery to specific action places, generating larger effectiveness of the treatments. In this line, the main proposal of this work involves the possibility to conjugate the property of the sunscreem octil salicilate with an antineoplasic 5-fluoruracil, by means of the latentiation process. For so much it was obtained pro-drug succinoil octil salicilate of 5-fluoruracil derived of the octil salicilate and 5- fluoruracil, starting from two synthetic stages, whose compositions were characterized by means of analyses IR spectra, melting point determination, thin layer chromatography and 13C and 1H MNR, extinction molar coefficient and partition coefficient. Tends SOSFlu presented better values of coefficients of extinction molar and of partition in relation to the sunscreen octil salicilate and to the antineoplasic 5-fluoruracil, it is waited that presents larger effectiveness to protect the skin against the ultraviolet radiation and larger cutaneous permeability.

No description available.

In this hands-on preconference workshop, we will introduce dermoscopy, a proven adjunctive tool that increases sensitivity and specificity of melanoma detection and improves diagnostic accuracy for basal and squamous cell carcinomas. Participants will learn how to use a dermatoscope in clinical practice and learn the two-step algorithm to diagnose unknown skin lesions and determine the need for biopsy. Biopsy techniques will be taught with a handson evidence-based approach that can be applied at one’s home institution. Participants will leave with fundamental competence in the use of dermoscopy for early skin cancer detection, improved understanding of biopsy techniques, tools to train others, free apps, Dermoscopedia, online resources, and online and in-person courses.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / In this research paper, we proposed an extended model for the early detection of skin cancer... The purpose is reduce the waiting time to obtaining a diagnosis, in addition, the function of the dermatoscope has been digitized by using a Smartphone and magnifying lenses as an accessory the mobile device. The proposed model has five phases: 1. The patient is attended by a general practitioner or nurse previously trained in any health center which has WiFi or mobile network connectivity to record their data and capture the skin lesion that will be analyzed. 2) The image will be in the cloud storage, which at the same time feeds an exclusive access website of dermatologists.3) Images are analyzed in real time using an image recognition service provided by IBM, which is integrated into a cloud-hosted web platform and an-Android application. 4)The result of the image processing is visualized by the dermatologist who makes a remote diagnosis.5) This diagnosis is received by the general practitioner or nurse, responsible for transmitting the diagnosis and treatment to the patient. This model was validated in a group of 60 patients, where 28 suffer from skin cancer in the early stage, 12 in the late stage and 20 are healthy patients, in a network of clinics in Lima, Peru. The obtained result was 97.5% of assertiveness on the analyzed skin lesions and 95% in healthy patients. / Revisión por pares

The research evaluated an intervention strategy designed to prevent skin cancer in young adolescents. The intervention used parents as change agents to effectively communicate the risks of skin cancer and encourage their children to avoid high-risk sun-related behaviors while increasing positive sun-safe behaviors. Three hundred and forty parents in two regions of the United States were educated about the dangers of risky sun behaviors and how to convey information about skin cancer prevention to their children. Parents were then encouraged to talk with their children about these issues over a 1-month period prior to the onset of summer. Following this time period, children whose parents received and implemented the intervention materials were compared with a control sample of 129 children. These two groups were matched on age, gender, and school on number of sunburns and sunburn severity, attitudes and beliefs, and sunbathing behavior. Children in the treatment condition differed significantly from controls in the predicted directions on all outcome variables. The findings are discussed in terms of reducing skin cancer risk behaviors of children via parent-based intervention approaches.