Essa dissertação aborda o estudo teórico, experimental e computacional de algumas configurações usuais para derivações de pequeno diâmetro, interligadas a uma tubulação principal, sujeitas à vibração. O estudo de vibração, induzida por diversos fatores, foi a base teórica utilizada para a previsão de esforços máximos admissíveis e garantia da confiabilidade das tubulações. A confecção dos corpos-de-prova buscou a reprodução de condições típicas de uso em instalações de petróleo e gás, visando uma comparação de desempenho para as diferentes condições de montagem. Também foi realizada uma etapa de avaliação computacional, usando o programa Triflex para verificação da frequência natural e rigidez do conjunto montado. As análises de deslocamentos e esforços através dos dados obtidos pela instrumentação das peças soldadas e resultados do programa ANSYS apresentaram resultados importantes, enfatizando a resistência mecânica de determinadas configurações de menor comprimento ou com reforço vinculado à tubulação principal, as quais podem ser utilizadas em projetos de tubulações, melhorando a confiabilidade das instalações. / This dissertation adresses the theoretical, experimental and computational study of some usual settings for small diameter pipe, connected to a main pipe, subject to vibration. The study of vibration induced by several factors was the theoretical basis used for predicting maximum permissible efforts and ensuring the reliability of pipes. The creation of the specimens sought to reproduce typical use conditions in the oil and gas factories aimed at comparative performance for different installation conditions. It was also performed a computational evaluation stage using software Triflex to check the natural frequency and rigidity of the mounted assembly. The displacement analysis and effort for parts by informations obtained with instrumentation of welded pipes and results of ANSYS software presented important results, emphasizing the mechanical strength of certain settings with smaller length or with reinforcement linked to a main pipe which can be used in pipe projects, improving the reliability of the facilities.

Essa dissertação aborda o estudo teórico, experimental e computacional de algumas configurações usuais para derivações de pequeno diâmetro, interligadas a uma tubulação principal, sujeitas à vibração. O estudo de vibração, induzida por diversos fatores, foi a base teórica utilizada para a previsão de esforços máximos admissíveis e garantia da confiabilidade das tubulações. A confecção dos corpos-de-prova buscou a reprodução de condições típicas de uso em instalações de petróleo e gás, visando uma comparação de desempenho para as diferentes condições de montagem. Também foi realizada uma etapa de avaliação computacional, usando o programa Triflex para verificação da frequência natural e rigidez do conjunto montado. As análises de deslocamentos e esforços através dos dados obtidos pela instrumentação das peças soldadas e resultados do programa ANSYS apresentaram resultados importantes, enfatizando a resistência mecânica de determinadas configurações de menor comprimento ou com reforço vinculado à tubulação principal, as quais podem ser utilizadas em projetos de tubulações, melhorando a confiabilidade das instalações. / This dissertation adresses the theoretical, experimental and computational study of some usual settings for small diameter pipe, connected to a main pipe, subject to vibration. The study of vibration induced by several factors was the theoretical basis used for predicting maximum permissible efforts and ensuring the reliability of pipes. The creation of the specimens sought to reproduce typical use conditions in the oil and gas factories aimed at comparative performance for different installation conditions. It was also performed a computational evaluation stage using software Triflex to check the natural frequency and rigidity of the mounted assembly. The displacement analysis and effort for parts by informations obtained with instrumentation of welded pipes and results of ANSYS software presented important results, emphasizing the mechanical strength of certain settings with smaller length or with reinforcement linked to a main pipe which can be used in pipe projects, improving the reliability of the facilities.

Essa dissertação aborda o estudo teórico, experimental e computacional de algumas configurações usuais para derivações de pequeno diâmetro, interligadas a uma tubulação principal, sujeitas à vibração. O estudo de vibração, induzida por diversos fatores, foi a base teórica utilizada para a previsão de esforços máximos admissíveis e garantia da confiabilidade das tubulações. A confecção dos corpos-de-prova buscou a reprodução de condições típicas de uso em instalações de petróleo e gás, visando uma comparação de desempenho para as diferentes condições de montagem. Também foi realizada uma etapa de avaliação computacional, usando o programa Triflex para verificação da frequência natural e rigidez do conjunto montado. As análises de deslocamentos e esforços através dos dados obtidos pela instrumentação das peças soldadas e resultados do programa ANSYS apresentaram resultados importantes, enfatizando a resistência mecânica de determinadas configurações de menor comprimento ou com reforço vinculado à tubulação principal, as quais podem ser utilizadas em projetos de tubulações, melhorando a confiabilidade das instalações. / This dissertation adresses the theoretical, experimental and computational study of some usual settings for small diameter pipe, connected to a main pipe, subject to vibration. The study of vibration induced by several factors was the theoretical basis used for predicting maximum permissible efforts and ensuring the reliability of pipes. The creation of the specimens sought to reproduce typical use conditions in the oil and gas factories aimed at comparative performance for different installation conditions. It was also performed a computational evaluation stage using software Triflex to check the natural frequency and rigidity of the mounted assembly. The displacement analysis and effort for parts by informations obtained with instrumentation of welded pipes and results of ANSYS software presented important results, emphasizing the mechanical strength of certain settings with smaller length or with reinforcement linked to a main pipe which can be used in pipe projects, improving the reliability of the facilities.

Small diameter trees refer to the trees with diameter at breast height (DBH) ranging from 5 to 11 inches. This research focuses on the resource analysis and spatial distribution of small-diameter tree (SDT) volume in Mississippi by a set of grouping variables including DBH class, species, stand size, forest cover type, ownership, and county groups. Regression and spatial interpolation techniques were used to predict the SDT volume for pine, hardwood, and mixed forest covers. Regression analysis resulted in a low regression coefficient (R2) without inventory data for all the forest cover types. The mean SDT volume to the total volume was greatest for pine (0.6), followed by mixed (0.4), and hardwood (0.3) forest cover. Non-spatial estimates indicated the total volume within respective groups. The spatial and non-spatial estimates of SDT resources can guide forest management personnel to effectively focus their management efforts.

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The design of polyethylene (PE) pipelines for applications in the gas, water and chemical process industries has been based on data mainly obtained from stress rupture testing pipes only. In practice, installations are composed of both extruded pipe and injection moulded fittings which are joined by a fusion welding technique and are very often subjected to internal pressures of a fluctuating nature. Several makes of PE pipe systems were therefore obtained and work was undertaken to fully characterise mechanical performance in terms of internal pressure loadings. Butt-welded test specimens comprising pipe lengths and fittings were subjected to both static and fluctuating conditions at 80°C, at pressures resulting in brittle fractures (below the knee on stress rupture curves) and at frequencies not exceeding 7.5 cpm (0.125 Hz). Resulting fracture surfaces were examined to identify sources of crack initiation and mechanisms of failure. Mechanical behaviour of the PE pipe samples was found to be markedly influenced by the grade of plastics compound, the pipe system dimensions, mould designs and methods of processing. Fatigue loading was the most aggressive test method and significant reductions in lifetimes were observed in fittings or joints between pipes and fittings with only modest increases in the frequency of pressurisation. It was also demonstrated that improved stress rupture behaviour did not necessarily lead to better fatigue performance. For the square-wave loading profiles used, an idea of the relevant failure mechanisms in any given system was obtained by comparing experimental Nf values with those predicted from cumulative damage principles based on Nf=τSR/τmax. In all types of system, failure was initiated at a defect residual from processing or jointing. Over 95% of all small diameter pipe fractures originated from inclusions at or close to the inside wall. They were geometrically and elementally analysed and suggestions made as to their possible origin and means of elimination. For one PE a reasonable correlation was obtained, between lifetime under stress rupture or fatigue and the inclusion size as measured in the fracture plane.

Indiana University-Purdue University Indianapolis (IUPUI) / Although paclitaxel is a commonly used anti-neoplastic agent for the treatment of solid tumors, therapy often results in a number of side effects, the most debilitating of which is peripheral neuropathy. Peripheral neuropathy is defined as a pathology of peripheral nerves, and, depending on the type of nerves damaged, the neuropathy can be classified as sensory, motor, or autonomic neuropathy. In the case of peripheral neuropathy induced by paclitaxel, the symptoms are experienced in the extremities and are sensory in nature. Patients undergoing chemotherapy with paclitaxel often report sensory disturbances such as burning, tingling, numbness, a diminished sensation to pain and temperature, loss of vibration sense, loss of proprioception, and loss of deep tendon reflexes. Electrophysiological abnormalities including decreased sensory nerve action potential amplitude and conduction confirm damage to large myelinated fibers. However, the involvement of damage to small diameter sensory neurons in the etiology of paclitaxel – induced peripheral neuropathy is still controversial. Therefore, experiments were performed to determine if paclitaxel alters the function of small diameter sensory neurons and to examine the mechanisms responsible for the change in function. vi Sensory neuron mediated vasodilatation in paclitaxel – injected animals was examined as an indirect measure of calcitonin gene related peptide (CGRP) release and therefore of sensory neuron function. CGRP release was also directly measured from central terminals in the spinal cord. To examine mechanisms of paclitaxel – induced sensory neuron damage, CGRP release and neurite length was examined in paclitaxel – treated sensory neurons in culture. The results demonstrate that (1) paclitaxel decreases the ability of small diameter sensory neurons to produce an increase in blood flow in the skin; (2) paclitaxel alters the release of CGRP from the small diameter sensory neurons; (3) paclitaxel causes the neuronal processes of isolated sensory neurons to degenerate. This dissertation provides novel information showing that paclitaxel alters the function of small diameter sensory neurons and thus provides a better understanding of the mechanisms mediating the sensory disturbances characteristic of peripheral neuropathy resulting from chemotherapy with paclitaxel.

The conversion of red oak small diameter timber (SDT) into solid wood products was investigated. The objectives of this research were to 1) determine the yield of lumber, pallet and container parts, and residues from SDT and the market potential for these products; 2) determine the economic feasibility of a SDT sawmill and pallet part mill located in Southwest Virginia; 3) develop a business plan for a SDT sawmill and pallet part mill located in Southwest Virginia. The methods for this research consisted of resource, yield and economic analyses, and the development of a business model. The resource analysis indicated an ample supply of red oak SDT available in Southwest Virginia. The yield analysis used red oak SDT logs, which were manufactured into lumber, container parts and wood residues. The yield of 3" wide container parts from cants varied from 63% to 66%. The 1" nominal lumber produced was mainly 2A and 3A, 74%, and 24% was 1 common. The economic analysis utilized break even, net present value and internal rate of return analyses to determine the economic feasibility of utilizing red oak SDT. The results of the study indicated that the sawmill-only processing level scenario is not economically feasible given the specified conditions and assumptions. However, the results showed that the sawmill and pallet part mill, actual yield scenario at $35/ton delivered log cost is economically feasible. The hypothetical business model for Southwest Custom Hardwoods was economically feasible. The final net present value was calculated to be over $750,000 and the final internal rate of return was 11%. Future yield studies should weigh logs so that the yield of residues and solid wood products can be directly compared. Future research into the utilization of hardwood SDT should include yield studies of other species and other product mixes. / Master of Science

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