Worldwide millions of children are victims of neglect and physical and mental harm, including sexual abuse and exploitation. South Africa, however, is widely believed to have not only one of the highest incidences of rape in the world, but also one of the highest levels of Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) transmission. With research findings showing that HIV and other Sexually Transmitted Infections (STIs) are rapidly increasing globally, young people are, and continue to be, at the forefront of the AIDS pandemic. Therefore, it is suggested that prevention programmes should be aimed particularly at the young. Schools have specifically been recognized as the setting for preventative Life Skills Programmes, having the potential to reach billions of children worldwide. The aim of this study is to explore and describe the perceptions of grade eight and nine learners with regard to the Life Skills Programme that focuses on HIV/AIDS and STI's, rape and child abuse education in the Port Elizabeth region. In order to fulfil the above aim, a qualitative study was undertaken within an exploratory descriptive approach. A non-probability sample of four schools was selected. Focus groups, utilising an unstructured interview, were used to gather qualitative data on the learners' perceptions of the Life Skills Programme. The focus groups consisted of 10 - 12 grade eight and nine learners who were selected using simple random sampling. The data was thematically analysed using Tesch's approach. The major findings of the present study, based on the six general themes, include the following: 1. Most of the learners perceived the educators, as well as the teaching methods utilised by the educators, positively. 2. Although the learners perceived the presenters of the Life Skills Programme positively, it was suggested that teachers, health care professionals, family members and peers should be involved in presenting the Life Skills Programme. 3. Learners reported various levels of comfort discussing different topics presented in the Life Skills Programme. 4. Learners of all the schools perceived the Life Skills Programme to be very relevant. 5. Learners recommended that more children, especially children from deprived communities, should be included in the programme. In addition, learners felt that counselling services should be available in conjunction with the Life Skills Programme. 6. Differences were noted in completing the first and the second questionnaire. Learners reported that they felt more comfortable completing the second questionnaire. They perceived the interviewing process positively.

The socio-economic impact of HIV/AIDS on South Africa has resulted in lower gross domestic product, loss of skills in key sectors such as education, and increased health-care costs in providing access to treatment. Currently active pharmaceutical ingredients (API’s) such as stavudine (d4T) and azidothymidine (AZT) are imported from India and China, while formulation is conducted locally. A strategy was initiated between CSIR Biosciences and LIFElab under the auspices of Arvir Technologies to investigate the feasibility of local antiretroviral manufacture (d4T and AZT) or the manufacture of a key intermediate such as β- thymidine (dT). Several advantages associated with successful implementation of this strategy include ensuring a local supply of API’s, thus reducing reliance on procurement from foreign sources and reducing the effect of foreign exchange rate fluctuations on providing cost effective access to treatment. A local supply source would also reduce the imports and thus aid the balance of payments deficit, and in addition to this, provide stimulus in the local pharmaceutical manufacturing industry (which has been in decline for several decades), resulting in increased skills and employment opportunities. This thesis describes the development of a superior chemo-enzymatic process for the production of β-thymidine (72 percent yield, prior to isolation), a key intermediate in the preparation of anti-retrovirals. Alternative processes based purely on chemical or bioprocess transformations to prepare either 5-methyluridine (5-MU) or dT suffer from several disadvantages: lengthy transformations due to protection/deprotection strategies, low selectivties and product yields (30 percent in the chemical process) and isolation of the product from dilute process streams requiring the use of large uneconomical reactors (bioprocesss). This contributes significantly to the cost of d4T and AZT manufacture. Our novel chemoenzymatic process comprises of a biocatalytic reaction for the production of 5-MU, with subsequent chemical transformation into dT (3 steps) negating and circumventing the limitations of the chemical or bioprocess routes. During the course of this project development, the β-thymidine selling price declined from 175 $/kg (2005) to 100 $/kg (2008). However, the process described in this work is still competitive based on the current β- thymidine selling price of 100 $/kg. The process economics show that with further optimization and increasing the isolated dT yield from 70 percent to 90 percent, the variable cost decreases from 136 $/kg to 110 $/kg. The increase in isolated yield is highly probable, based on solubility data of β-thymidine. The decrease in β-thymidine selling price and technological improvement in dT manufacture should translate into lower API manufacture costs and more cost effective access to treatment. Our novel biocatalytic process producing 5-MU uses a coupled enzyme system employing PNP, Purine Nucleoside Phosphorylase and PyNP, Pyrimidine Nucleoside Phosphorylase. The overall transglycosylation reaction may be decoupled into the phosphorolysis reaction (PNP) and synthesis reaction (PyNP). During the phosphorolysis reaction, guanosine is converted into guanine and ribose-1-phosphate (R-1-P) in the presence of PNP enzyme. The reaction intermediate R-1-P is then coupled to thymine in the presence of PyNP enzyme during the synthesis reaction, producing 5-MU. The process was scaled up from lab-scale to bench-scale (10 - 20 L) and demonstrated to be robust and reproducible. This is evident from the average guanosine conversion (94.7 percent ± 2.03) and 5-MU yield (88.2 percent ± 6.21) and mole balance (104 percent ± 7.61) which were obtained at bench-scale (3 replicates, 10 L). The reaction was carried out at reactor productivities of between 7 – 11 g.L-1.h-1. The integration of the biocatalytic process and chemical processes was successfully carried out, showing that 5-MU produced using our novel biocatalytic process behaved similarly to commercially available 5- MU (ex. Dayang Chemicals, China). A PCT patent application (Ref. No. P44422PC01) on this chemo-enzymatic process has been filed and currently public private partnerships are being explored through Arvir Technologies to evaluate and validate this technology at one ton scale.

Surveys have shown that alcohol misuse is the biggest substance misuse problem in the world today, affecting millions of people. With the disease being part of a family, all members of the family experience the distress of parental alcohol misuse. While the challenges that these families have to face are many, they seem to have the ability to “bounce back”, in other words, have resilience. There has been limited research to date on family relations and alcohol misuse in South Africa, especially in terms of the parental member as the alcohol misuser. The proposed research aimed to explore and describe the factors that facilitate adjustment and adaptation in families where a member misuses alcohol. The Resiliency Model of Family Stress, Adjustment and Adaptation was used to analyze the factors that enable a family to adapt to the alcohol misuse, as outlined in the broader study at the University of Stellenbosch. An exploratory descriptive research design was employed in the proposed study. For the purposes of this study, the researcher combined qualitative and quantitative research methods in order to use their complementary strengths to enrich the data obtained from the proposed study. Sixty three families were surveyed using a biographical questionnaire and seven pencil-and-paper questionnaires. These families were accessed via drug and alcohol rehabilitation facilities throughout South Africa. The data from the biographical questionnaire was analyzed using descriptive statistics, while the qualitative data was analyzed using content analysis. The quantitative data was analyzed using correlation and regression analysis. The findings of the proposed research allow for better management of the alcohol misuser’s condition through the understanding of what resiliency areas the family may improve upon. Furthermore, the study can be used as a stepping stone for future research of resilience in families living with a parental member who misuses alcohol, and ultimately contributes to the broader context of family resilience research in South Africa. Key words: alcohol misuse, alcohol abuse, alcohol dependence, family, resilience, adjustment, adaptability.

Schools play a major role in shaping the attitudes, opinions and behaviour of young people and so are ideal environments for teaching the social, as well as biological aspects of HIV and AIDS. However, literature indicates that learners are displaying “AIDS fatigue” and may be resistant to teaching around HIV and AIDS. In order to enhance learner engagement and learning, there is therefore a need for teachers to employ interactive teaching and learning strategies that are interactive, inexpensive and fun. This dissertation outlines the research design of an investigation into how such strategies can be used in HIV and AIDS prevention education. An action research design was made use of in this study and the manner in which several teachers presented HIV and AIDS education to his/her learners was initially observed. In addition, qualitative interviews were used to determine the teachers‟ need for development in this regard. Based on the findings of the problem identification step, teachers were introduced to active teaching and learning strategies and supported to implement them. Evaluation and refinement of the strategies, developmental workshops and training followed, which in turn lead to recommendations and the formulation of guidelines to influence teacher education with regard to HIV and AIDS prevention education.

M.A. (Political Science) / Although an effective cure for tuberculosis exists, the incidence and mortality rate for TB in South Africa remain exceptionally high. The reason for this is both medical as well as sociopolitical. The purpose of this dissertation is to examine the inter-action of various differential variables which influence the control of TB in this country. TB whilst caused by a germ, is adversely affected by socioeconomic deprivation, which in turn has distinct political connotations in South Africa. The dissertation therefore examines the inter-play of the historical and present influences of sociopolitical factors on the TB situation at present. Another important aspect of TB control is the State's efforts to control TB through the TB Control Programme (TBCP). This dissertation discusses the objectives of the TBCP and meaSures its effectivity against the socio-political context in which it functions. This is followed by a series of suggestions including an examination of the financial implications of these. A non-governmental organisation (NGO), SANTA ( The South African National TB Association) is a further actor in the control of TB. As specified delegates of the State for TB health education, it is essential that their role be examined both in terms of the TBCP as well as in terms of their own stated objectives for TB control. This includes an examination of the role of NGOs in complimenting the activities of the State and their believability in the community they claim to serve. Further proposals are put forward with regard to ways in which SANTA can improve their believability, relevance and effectivity within TB control in South Africa. Further influencing factors are the impact of AIDS and political violence on TB and the ability of the various actors to control TB. These two aspects are discussed briefly and constitute areas for further research. In addition it would be relevant for some form of cost-benefit analysis to be conducted, in order to extend the scope of the policy analysis conducted here.

Philosophiae Doctor - PhD / The main goal of this study was to develop assessment and intervention guidelines that will provide practitioners with a framework to develop and implement batterer intervention programmes. The development of batterer intervention programmes must be informed by risk-based assessment and the study has identified this as a priority. This priority was informed by the popular notions that batterer intervention by itself, is futile and that intervention efforts were misdirected and useless. The author was of the opinion that if specific risk markers were identified, the batterer intervention efforts could be a tool to influence the values, beliefs and dangerous behaviours of abusive men. This study attempted to formally identify those risk factors that should be considered with batterers so that appropriate guidelines for assessment and intervention could result. / South Africa

Thesis (MPA.) -- University of Limpopo, 2017 / The aim of this study was to assess the effectiveness of the measures in the prevention and control of organised crime by government agencies based in Limpopo Province. The research was qualitative in nature and semi-structured interviews were conducted with 12 law enforcement officers from the DPCI, DSSL, SAPS, Home Affairs, SARS Customs and Excess, AFU, and the NPA PCLU. Data was analysed though thematic analysis. The results revealed that the government strategies in Limpopo still require concerted efforts in the prevention and control of organised crime. The government has identified measures to fight organised crime and has adopted the criminal justice response/ institutional and the legislative response to the crime. The measures taken by various units are found to be ineffective in dealing with organised crime since organised criminal networks are often flexible, dynamic, innovative and resilient. Furthermore, corrupt activities and collusions by law enforcement officers hinder the effective implementation of the strategies to control organised crime. The findings of the study show that there is coordination and communication among the law enforcement agencies such as the DPCI, SARS, Home Affairs, and the NPA PCLU, among others. This coordination is envisaged through intelligence, information sharing and interoperability. The study highlighted poor implementation of the multi-agency approach as one institution is expected to facilitate and lead the prevention of organised crime (which is the DPCI). The findings further highlight, for example, that the smuggling of illegal cigarettes is currently a challenge for the provincial government as a highly committed organised crime. The study recommends for the development, by the government, of an Organised Crime Threat Assessment in order to effectively recognise the need for responses, which should be based on a sound understanding of the nature and characteristics of the organised crime environment. In addition, it recommends for the development of an Organised Crime Response Plan to align efforts to identified critical organised crime threats. The study further recommends for the adoption, by the government, of relevant multi-agency approaches in addressing organise crime – both operational and policy or regulatory – which will underpin a whole-of-provincial government approach to organised crime. KEY WORDS: Organised Crime, Criminal, Crime Prevention, Crime Control, Effectiveness, Coordination.

A Research Report Submitted to the Faculty of Commerce, Law and Management in Partial Fulfilment of the Requirements for the Degree of Master of Commerce (Specialising in Taxation) / In the 2016 Budget Speech, the then Minister of Finance, Pravin Gordhan, announced a decision to introduce a Health Promotion Levy (‘sugar tax’) on sugar-sweetened beverages (‘SSBs’). Sugar tax came into effect on 1 April 2018 in South Africa. In its Policy Paper released by the National Treasury in July 2016, titled “Taxation of Sugar Sweetened Beverages” (‘Policy Paper’), the National Treasury outlined the proposed sugar tax. It argued that the primary objective of the introduction of sugar tax was to reduce excessive sugar intake and curb the growing problem of obesity. Obesity and other non-communicable diseases (‘NCDs’) have significantly escalated over the past 30 years and has become a growing concern in South Africa. This has resulted in South Africa being ranked the most obese country in sub-Saharan Africa. The impact of SSBs on obesity and other NCDs has received widespread attention on the international stage and by the World Health Organisation (‘WHO’). This is evident from the fact that South Africa is not the first country in recent years to introduce a form of sugar tax which has been gaining traction as popular intervention to combat the growing concern of NCDs. The argument arises as to whether the tax is actually intended to meet its desired health benefits or simply increase revenue for the fiscus. This research will examine whether the implementation of sugar tax will contribute to its intended health objectives envisaged. In order to achieve this, a study will need to be undertaken with countries which have successfully introduced sugar tax including, Mexico, Norway, Denmark, the United Arab Emirates, Chile and United Kingdom. Lastly, this study will also explore the success of the implementation of sugar tax and the impact it has had on the fiscus of these countries. / NG (2020)

Corruption, understood as the misuse of public office for private gain, has become a matter of global concern. Numerous measures being taken, not least in South Africa, to contain its spread are increasingly regarded as attempts in "fighting corruption". The South African public sector provides the context for this study where manifestations of corrupt behaviour may be observed and analysed. Particular attention is given to the role, relevance and costs which, as this study shows, must first be calculated in monetary terms as a fiscal end in order for the task of fighting corruption to produce a sustainable impact. The national strategy developed by the South African government has been compromised by the absence of sufficient resources being committed from the national fiscus for its implementation. It is misleading to assume that new laws and tighter regulations will of themselves serve to deter corrupt practices. One notices a plethora of public administration reforms being initiated to control and prevent corruption in line with international best practice. Yet, as this study concludes, such efforts even at higher fiscal cost will not necessarily contribute to reduced corruption. No attempt should be made to create a situation of a "zero tolerance" level of corruption as this is not possible. Ultimately, the challenge for the South African public sector is to seek ways of rationalising existing resources such that a single agency led by someone with moral authority can be vested with powers to lead the fight against corruption. / Public Administration / (D. Litt. et Phil. (Public Administration)

Submitted in fulfillment of the requirements for the degree of Master of Technology, Information Technology, Durban University of Technology, Durban, South Africa, 2013. / This study reports on the application of decision making core technology adoption theory to empirically examine youth preferences for Human Immunodeficiency Virus (HIV) preventive actions. In order to contribute to the open discourse on whether technology adoption rate is higher for male or female, goal desire, goal intention, action desire and action intention elements of decision making core theory were tested. A mobile health information system was implemented as an HIV information disseminating tool and used for experimentation to determine adoption by youths. A dataset of 118 pupils from two high schools was used for pilot investigation. A dataset of 292 undergraduate youths aged 10-24 years from two universities in South Africa was generated to validate the research model. The Partial Least Square (PLS) analytic modelling technique was used to determine the predictive power of decision making core model from the input dataset. Results of experimentation show that regardless of the gender youth accepts to use mobile information system to access HIV information. The predictive power of the decision making core model was found to be independent of gender factor, which was also not found to moderate the relationship between Perceived Behavioural Control (PBC) and action intention. In addition, gender was not found to moderate the order of importance in factors that predict youth preferences for HIV preventive action. PBC, action desire and goal desire were selected as the most important predictors of HIV preventive actions. The factor of action desire was found to mediate the relationship between PBC and action intention such that the mediation effect was stronger for male youth (68%) than for female youth (19%). Finally, the decision making core model better predicted youth preferences for HIV preventive actions as compared to two models based on Theory of Reason Action (TRA) and Theory of Planned Behaviour (TPB).