Thesis (M.F.A.)--University of California, San Diego, Dept. of Visual Arts, 1986. / Catalog of an exhibition held Jan. 28-Feb. 1, 1985 at the Mandeville Annex Gallery, University of San Diego, California. Also issued in print.

Thesis (M.F.A.)--University of California, San Diego, Dept. of Visual Arts, 1986. / Catalog of an exhibition held Jan. 28-Feb. 1, 1985 at the Mandeville Annex Gallery, University of San Diego, California. eContent provider-neutral record in process. Description based on print version record.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1981. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 280-285).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1982. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 245-252).

Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 215-217).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1975. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Plasmalemmale Kalzium- und Kaliumkanäle sind wichtige Regulatoren der kontraktilen Kraft glatter Gefäßmuskelzellen. Bei Untersuchungen an einer Vielzahl nicht humaner glatter Muskelzellen wurden verschiedene Kalzium- und Kaliumkanaltypen identifiziert. Allerdings ist über das Vorkommen, die biophysikalisch-pharmakologischen Eigenschaften, Regulation, Bedeutung und differentielle Expression von spannungsabhängigen Kalzium- und Kaliumkanälen in humanen arteriellen Gefäßmuskelzellen noch wenig bekannt. In dieser Arbeit wurden spannungsabhängige Kalzium- und Kaliumkanalströme in frisch-isolierten Gefäßmuskelzellen humaner Koronararterien analysiert. Die wichtigsten Ergebnisse waren: (1) Gefäßmuskelzellen humaner Koronararterien exprimieren funktionell aktive spannungsabhängige L-Typ-Kalziumkanäle. (2) Die hohe Permeationsrate von L-Typ-Kanälen in Lösungen mit physiologischer Ca2+-Konzentration wird durch die (1- Kanaluntereinheit bestimmt. (3) L-Typ-Kanäle der C-Klasse werden durch G-Proteine und Proteinkinase C moduliert. (4) Die Expression von L-Typ-Kanälen in Gefäßmuskelzellen wird differentiell reguliert. (4) Vier diverse Kaliumkanalströme kommen in Gefäßmuskelzellen humaner Koronararterien vor: IK(dr), IBK(Ca), IK(ATP) und STOCs. (5) Spontane transiente Auswärtsströme (STOCs) werden durch Ca2+-Sparks ausgelöst. (6) Ca2+-Sparks entstehen durch Öffnung von Ca2+-Freisetzungskanälen (Ryanodinrezeptoren) des sarkoplasmatischen Retikulums. (7) KATP-Kanäle fungieren als Zielstruktur für diverse endogene und synthetische Vasodilatatoren. (8) Ca2+-Sparks und STOCs bewerkstelligen die Feineinstellung des myogenen Gefäßtonus. (9) Der Ca2+-Spark/STOC-Signalweg stellt potenziell ein neuartiger Angriffsort für Hormone und Pharmaka dar, über den der Gefäßtonus von geringlumigen Arterien beeinflusst werden kann. Diese Ergebnisse tragen zum Verständnis der Bedeutung von plasmalemmalen Ionenkanälen bei chronischen Gefäßerkrankungen wie Atherosklerose und Hypertonie bei und eröffnen möglicherweise neue therapeutische Möglichkeiten. / Plasmalemmal calcium- and potassium channels represent important regulators of the contractile force of smooth muscle. Studies on various human smooth muscle cells have identified different calcium and potassium channels. However, relatively little is known on the presence, biophysical and pharmacological properties, regulation, function, and differential expression of voltage-dependent calcium and potassium channels in human coronary arteries. In this study, voltage-depedent calcium and potassium channels in human coronary arteries were studied. The main findings are: (1) Smooth muscle cells of human coronary arteries exhibit functional voltage-dependent, L-type calcium channels. (2) The high permeation rate of L-type channels in solutions with physiological calcium concentrations is determined by the (1 channel subunit. (3) C-class L-type channels are modulated by G proteins and protein kinase C. (4) The expression of L-type channels in vascular smooth muscle cells is differentially regulated. (4) Four diverse potassium channel currents are present in smooth muscle cells from human coronary arteries: IK(dr), IBK(Ca), IK(ATP) and STOCs. (5) Spontaneous transient outward currents (STOCs) are induced by Ca2+ sparks. (6) Ca2+ sparks are generated by the opening of calcium release channels (ryanodine receptors) in the sarcoplasmic reticulum. (7) KATP channels function as target for diverse endogeneous and synthetic vasodilators. (8) Ca2+ sparks and STOCs control the myogenic tone of arterial vessels. (9) The Ca2+ spark/STOC signaling pathway represents a novel target for hormones and drugs to regulate the diameter of small, resistance-sized arteries. These results contribute to a better understanding of the role of plasmalemmal ion channels in chronic vascular disease, such as atherosclerosis and hypertension. They may open novel therapeutic possibilites in the treatment of chronic vascular disease.

Thesis (MScEng)--Stellenbosch University, 2013. / ENGLISH ABSTRACT: This thesis comprises of the development of a facility were spark ignition engine fuels can be tested. Development of the facility included the installation of a standard spark ignition engine, an engine dynamometer, control and monitoring equipment, control and monitoring software, and an in-cylinder pressure measurement setup. The system was tested using petrol as well as a petrol-ethanol blend. The results indicated good accuracy and repeatability of the system. Analysis of the performance and combustion of the petrol-ethanol blend showed no significant difference in comparison to the petrol fuel. The petrol-ethanol blend showed a slight increase in oxygen content and fuel consumption as well as an increase in CO2 emissions and a decrease in CO emissions. During the project, a comparison was also made between the performance of fibre optic transducers and a piezoelectric transducer. It was found that the fibre optic transducers performed similarly to the piezoelectric transducer during low engine load conditions. At high load conditions however, the fibre optic transducers were not able to produce the same accuracy as the piezoelectric transducer. / AFRIKAANSE OPSOMMING: Hierdie tesis bestaan uit die ontwikkeling van 'n fasiliteit waar brandstowwe vir 'n vonkontsteking binnebrandenjin getoets kan word. Ontwikkeling van die fasiliteit sluit in die installering van 'n standaard vonkontsteking binnebrandenjin, 'n enjin rem, beheer en monitering toerusting, beheer en monitering sagteware, en 'n insilinder drukmeting opstelling. Die fasiliteit is getoets met suiwer petrol sowel as 'n petrol-etanol mengsel. Die resultate het hoë vlakke van akkuraatheid en herhaalbaarheid getoon. Ontleding van die werksverrigting en verbranding van die petrol-etanol mengsel het geen beduidende verskil getoon in vergelyking met die suiwer petrol brandstof nie. Die petrol-etanol mengsel het 'n effense toename in suurstofinhoud, brandstofverbruik, sowel as CO2 vrylating en 'n afname in CO vrylating getoon. Tydens die projek is 'n vergelyking getref tussen die akkuraatheid van optiese vesel drukmeters en 'n piësoëlektriese drukmeter. Daar is bevind dat die akkuraatheid van die optiese vesel drukmeters soortgelyk is aan die piësoëlektriese drukmeter gedurende lae enjin lastoestande. By hoë las omstandighede was die optiese vesel drukmeters egter nie in staat om dieselfde akkuraatheid as die piësoëlektriese drukmeter te handhaaf nie.

Typescript, etc. / Digitized by Kansas Correctional Industries

Typescript, etc. / Digitized by Kansas Correctional Industries