Investment of mutual fund has always been popular to the common investor. No matter investing at Systematic Investment Plan or One-time Investment, choosing a ¡§good¡¨ mutual fund is expected for every investor. However, how to find a good one among a large number of funds? In the past reports or theses, there are many reasons of influencing mutual fund performance, which include fund¡¦s size among others. The common sense said that ¡§if you want to invest in mutual fund, you should choose the larger size ¡¨ Is that true? Through the past reports we can find out different opinions. This study mainly research into the relationship between performance and size of domestic open-ended mutual funds. Expect to give a simpler data for reference and lower the risk before general investors put money into funds. The logic of Spearman's Rank Correlation coefficient would be applied as the statistical inference in this study, and the domestic open-ended equity fund, balanced fund, and quasi-money market fund will be used as the observed samples. Monthly performance and size is the observed unit of time in this research period from March 2001 to February 2010. Thus via this mode will know whether the correlation between fund¡¦s performance and size is positive, negative or there is no correlation. The conclusions of this study are presented as follows: 1. There is a low positive correlation between performance and size for equity fund and quasi-money market fund. But the balanced fund does not show any correlation for these two variables. 2. Moreover, the study shows there is better performance for investing in over 4 billion NT asset of equity fund in a short term period. But the result of balanced fund and quasi-money market fund can¡¦t highlight the optimal size in a short term period. 3. From the long term point of view, the optimal interval of size for equity and balanced fund is between 1 billion and 2 billion. And the optimal size to quasi-money market fund is over 40 billion.

The Plasmodium vivax Duffy Binding Protein (DBP) is the ligand in the major pathway for P. vivax invasion of human reticulocytes, making it an appealing vaccine candidate. Region II of DBP (DBP-RII) is the minimal portion of the ligand that mediates recognition of the Duffy Antigen Receptor for Chemokines (DARC receptor) on the reticulocyte surface and constitutes the primary vaccine target. Analysis of natural variation in the coding sequences of DBP-RII revealed signature evidence for selective pressure driving variation in the residues of the putative receptor-binding site. We hypothesize that anti-DBP immunity in P. vivax infections is strain-specific and hindered by polymorphic residues altering sensitivity to immune antibody inhibition. To comprehend the human IgG response following P. vivax infections we investigated the specificity of IgG in Pursat Province, Western Cambodia. Using ELISAs, we quantified the antibody titer against five variant alleles of DBP-RII. We also sequenced the DBP-RII of the field isolates to determine their relationship to the variant alleles used in the ELISAs. When correlating the IgG titer between the DBP variants a strain-specific immune response was observed in patients with a high antibody titer to DBP-RII_AH as compared to the other variants. This was different from the correlation of high antibody titers between DBP-RII_P and DBP-RII_7.18 (ρ=0.88, p-value<0.0001) and DBP-RII_P and DBP-RII_O (ρ=0.87, p-value<0.0001). There appeared to be little correlation between specific polymorphic residues and IgG titer. Understanding the immune response to the polymorphisms within PvDBP will allow further identification of epitopes to enable the production of a more effective P. vivax vaccine

在國內外實證文獻中，已有許多學者研究市場過度反應的現象，但由採取的研究方法不盡相同，故結論也有所差異．本研究是希望能對台灣股市的個別股票報酬率作一較完整的檢視，先瞭解股票報酬率前後期的相關情形，試圖找出一些一致性，再提出股市交易的策略，並比較策略的獲利性。 將樣本分成對稱與不對稱的形成期及檢定期，採Spearman等級相關係數法先對台灣股市同一股票的報酬率在不同期間（形成期及檢定期）的表現是否有相關作一檢視，接著檢定此相關係數時間序列是否具有隨機的特質，而後將證券交易稅及手續費納入考慮後，比較三種投資策略－買入持有輸家、中間、贏家的獲利性、風險及績效表現。 本文的實證結果：由單位風險報酬率來看，投資股市應以買入有長期的策略才會有較好的績效表現，而買入持有短期的績效是最差的。以不同的樣本期間討論台灣股市是否有價格反彈，結果並不相同。在1980年-1998年的Spearman等級相關係數多為正值，表示市場在288天以下多沒有價格反彈，且以連檢定的結果多為顯著，以Jensen α檢定之，贏家投資策略能獲得超額報酬。在1990年-1998年不論是重覆取樣、未重覆取樣，Spearman等級相關係數，多為負值，表示市場應存有價格反彈的現象，且以連檢定的結果多為顯著，但以Jensen α檢定之，輸家卻無法獲得超額報酬。可能是因為考慮了交易稅與手續費，而影響了投資策略的獲利性。 / There have been many articles discussing overreaction. Because of the difference of methods and samples, the conclusions are different. This thesis tries to make a more complete examination of Taiwan Stock Market. We divide sample period to be formation period and test period which are symmetric and asymmetric. Besides that, we adopt overlapping and nonoverlapping sampling. The sample period is 1980 January 1 to 1998 January 22. Three investment strategies are buying and holding loser portfolio、middle portfolio and winner portfolio. We use Spearman rank correlation to discuss whether the return of Taiwan Stock Market has correlation between formation period and test period. Then we adopt one of nonparameter statitics analysis－run test to examine whether the time series of Spearman rank correlation is a random walk. Following are our summaries： 1.The longer period we hold the stock,the better return we acquire. 2.In the first sample (1980 Jan 1 to 1998 Jan 22), Spearman rank correlation. is almost positive, and the hypothesis of run test is significant. We imply buying and holding the winner portfolio is the best strategy. We can prove this by using Jense α. In this case, buying and holding winner can get excess return. 3.In the second sample(1990 Nov 1 to 1998 Jan 22), Spearman rank correlaion is almost negative, and the hypothesis of run test is signficant. We imply buying and holding the loser portfolio is the best strategy. But we can not prove the by using Jense α. As we can not acqure excess return by buying and holding loser portfolio.