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En este trabajo de tesis se describirá una técnica de modelado centrado en mockups, introduciéndola primero con MockupDD Web. Luego de haber ejemplificado el desarrollo centrado en mockups para metodologías MDWE, se describirá un marco general para el modelado sobre mockups (lo que se referenciará como metodología MockupDD general) y una instanciación particular de esta metodología además de la ya presentada para la Web. Las principales contribuciones de la metodología MockupDD y sus especializaciones son: (1) Mejorar el workflow en cascada de las metodologías MDD tradicionales (en especial, aquellas MDWE) para permitir acortar las iteraciones y permitir a usuarios finales y clientes involucrados interactuar más rápidamente son el software generado, agilizando el proceso. (2) Mejorar la productividad en el modelado de aplicaciones a través de la técnica de modelado de aplicaciones sobre mockups reduciendo sus errores y tiempo requerido, como se mostrará luego en las secciones de validación (3) Introducir a clientes y usuarios finales en el proceso de desarrollo, utilizando artefactos de especificación de requerimientos de fácil comprensión para los mismos en lugar de conceptos de modelado comprensibles sólo para desarrolladores. En este contexto se utilizarán mockups y diferentes técnicas de anotación y especificación de requerimientos formales sobre los mismos. (4) La implementación de un lenguaje de modelado sobre mockups con diferentes vistas, satisfaciendo al mismo tiempo la necesidad de comprensión de requerimientos por parte de los usuarios finales y las capacidades técnicas requeridas por los desarrolladores. (5) Con ayuda de esta versatilidad del lenguaje y del uso de mockups (los cuales son comprensibles en su totalidad por usuarios finales), proveer un método de modelado más trazable desde el punto de vista de los requerimientos.

The objective of the above project is to present a tool that can be used by educators in landscape architecture and architecture to affect how students, as designers, gather and manipulate poetic and descriptive material used in designing landscapes and places. The design tool, a set of skill sheets, each of which uses language, literature, and metaphorical thinking as primary components, is designed to exercise a way of seeing and thinking about landscapes that provides access to potential design material. The ultimate intended effect of the use of this tool is to enhance the descriptive significance of student work. Within the context of this project, descriptive significance is defined as work that is 1) original, i.e., an expression of individual insight as a result of the process of engaging one's critical faculties of observation, perception, thought, and imagination; 2) context-related, i.e., related to the specifics of place including thenatural, physical/environmental, cultural, and historic context; 3) environmentally sound, i.e., respecting sensitive natural and environmental interrelationships; 4) wellcrafted i.e., attentive to the inherent. qualities of the design materials used; and work that 5) contributes to an understanding of the specifics of place, i.e., reveals something significant about a particular landscape or place. / Department of Landscape Architecture

Malaria is a disease affecting millions of people in 109 malarious countries and territories, causing approximately one million deaths annually. In 2004 one of the parasites causing human malaria, Plasmodium falciparum, was among the leading global causes of death from a single infectious agent, especially in Africa (WHO, 2008:23). Treatment of this disease with single active pharmaceutical ingredients has led to the emergence of resistant P. falciparum parasites, resulting in the most severe form of this illness. Alarmingly, the poor quality of commercially available antimalarial products, especially in Africa, has increasingly been reported as a major cause of resistance to antimalarials. In Pakistan it was found that a P. falciparum epidemic that initially was attributed to drug resistance, was actually caused by substandard sulfadoxine/pyrimethamine products, causing a 50 times higher incidence of malaria in these areas than elsewhere (Leslie et al., 2009:1758). Other results indicated that up to 10% of sulfadoxine/pyrimethamine tablets, sampled in six African countries, failed the assay test, whilst up to 40% failed the USP dissolution test. Furthermore, the World Health Organization (WHO) reported that 20 - 90% of products failed quality requirements during 1999 and 2000 in seven African countries (WHO, 2003:263). Cases like these have raised the awareness of the vast number of inferior products that are being distributed. The subsequent need for establishing mechanisms to proactively detect substandard medicines, specifically antimalarials, easily and effectively had indirectly led to the origin of this study, long before it was formally undertaken. Testing monographs for pharmaceutical products are developed to formalise, or standardise, the regulation of pharmaceutical dosage forms. Problems have, however, been reported with regards to the inadequacy of existing antimalarial monographs in assuring quality medicines, fit for their intended use. The WHO had requested the Research Institute for Industrial Pharmacy, incorporating the Centre for Quality Assurance of Medicines (RIIP®/CENQAM®), both operating at the Potchefstroom Campus of the North–West University, to develop monographs for three immediate–release antimalaria dosage forms, namely amodiaquine tablets, sulfadoxine/pyrimethamine fixed–dose combination tablets and mefloquine tablets. The undertaking of these projects, to develop specifications for the quality control of these pharmaceutical products, formed the object of this research study. Data had been accumulated since 2000, as a result of continuous requests by the WHO to help solve problems that had been experienced with analytical test methods, especially from manufacturers. These requests either led to the refinement of existing methods, or to the development of new ones. The success with which these outcomes were implemented worldwide, finally led to the decision to publish these research findings under the umbrella of this project. The proud product is a comprehensive package of tests for three commercial antimalarial products, the outcomes of which are hoped to contribute towards the combat against resistance formation to these important disease fighters. / Thesis (Ph.D. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.

This study was to develop an instrument for the collection of data relative to construction of public school buildings for the state of Indiana. The number of totally new public schools for which construction contracts were let in Indiana between January 1, 1966 and December 31, 1968 was to be determined. A third purpose of the study was to identify selected predominate physical components used in the construction of school buildings included in the study. A final purpose was to determine the percentage range of expenditures for each of the selected contracts relative to the total cost of the individual facility, as well as the total cost of construction of school buildings included in the study.Procedures and MethodologyThe research design used in this study included the following procedures: (1) determining the totally new public school construction projects; (2) preparation and refinement of the data gathering instrument; (3) data gathering activities; and (4) treatment of data.Public school construction projects for totally new structures for which construction contracts were let in Indiana between January 1, 1966 and December 31, 1968 were included in the study. A printed questionnaire was mailed to school superintendents in which such a construction project was located. The population consisted of 113 facilities of which responses were received concerning 106 or 9308 per cent. A percentage range of selected contract costs was computed for each individual facility and a frequency tabulation was made on the most often used selected physical component.FindingsOf the 106 buildings included in the study 69 or 65,09 per cent were one story construction. Seventy-four or 69.81 per cent used a steel framing system, 100 or 94°33 per cent used brick exterior walls, 38 or 35,84 per cent used unit ventilators for heating and cooling, 67 or 63.2 per cent had cooling to some extent, 58 or 54.71 per cent used natural gas for heat energy, 65 or 61.32 per cent used carpeting on less than 50 per cent of the floor surface, and 52 or 49.05 per cent used non-load bearing walls as interior partitions. The predominate selected physical component was computed for classified buildings based on grades housed.The percentage range of the general contract cost ranged from a low of 40.92 per cent to a high of 70.97 per cent of the total cost of the individual facilities. The percentage range for the mechanical contract was from a low of 7.25 per cent to a high of 25.61 per cent of the total cost of the individual facility. The percentage range of the electrical contract was from 5.1 per cent to 20.69 per cent and the architect's commission percentage range was from 2.11 per cent to a high of 6.92 per cent of the total cost of the individual facility. Other cost findings were presented in the study.Conclusions1. The great range of construction costs indicates many school administrators lack time, training, and experience to serve effectively as coordinators for planning outstanding and economical school plants.2. A significant number of school facilities included in the study were designed in such a manner as to virtually eliminate flexibility.3. A significant number of elementary schools failed to incorporate environmental comfort features, such as carpeting and air conditioning.4. The fees for legal services rendered in connection with construction of school facilities varied greatly.5. The sale of general obligation bonds was an inadequate method of financing school construction in Indiana.6. If school districts are going to realize a reduction in the amount of the total obligation incurred in financing school construction costs the state of Indiana must provide additional funds for financing school construction.

Malaria is a disease affecting millions of people in 109 malarious countries and territories, causing approximately one million deaths annually. In 2004 one of the parasites causing human malaria, Plasmodium falciparum, was among the leading global causes of death from a single infectious agent, especially in Africa (WHO, 2008:23). Treatment of this disease with single active pharmaceutical ingredients has led to the emergence of resistant P. falciparum parasites, resulting in the most severe form of this illness. Alarmingly, the poor quality of commercially available antimalarial products, especially in Africa, has increasingly been reported as a major cause of resistance to antimalarials. In Pakistan it was found that a P. falciparum epidemic that initially was attributed to drug resistance, was actually caused by substandard sulfadoxine/pyrimethamine products, causing a 50 times higher incidence of malaria in these areas than elsewhere (Leslie et al., 2009:1758). Other results indicated that up to 10% of sulfadoxine/pyrimethamine tablets, sampled in six African countries, failed the assay test, whilst up to 40% failed the USP dissolution test. Furthermore, the World Health Organization (WHO) reported that 20 - 90% of products failed quality requirements during 1999 and 2000 in seven African countries (WHO, 2003:263). Cases like these have raised the awareness of the vast number of inferior products that are being distributed. The subsequent need for establishing mechanisms to proactively detect substandard medicines, specifically antimalarials, easily and effectively had indirectly led to the origin of this study, long before it was formally undertaken. Testing monographs for pharmaceutical products are developed to formalise, or standardise, the regulation of pharmaceutical dosage forms. Problems have, however, been reported with regards to the inadequacy of existing antimalarial monographs in assuring quality medicines, fit for their intended use. The WHO had requested the Research Institute for Industrial Pharmacy, incorporating the Centre for Quality Assurance of Medicines (RIIP®/CENQAM®), both operating at the Potchefstroom Campus of the North–West University, to develop monographs for three immediate–release antimalaria dosage forms, namely amodiaquine tablets, sulfadoxine/pyrimethamine fixed–dose combination tablets and mefloquine tablets. The undertaking of these projects, to develop specifications for the quality control of these pharmaceutical products, formed the object of this research study. Data had been accumulated since 2000, as a result of continuous requests by the WHO to help solve problems that had been experienced with analytical test methods, especially from manufacturers. These requests either led to the refinement of existing methods, or to the development of new ones. The success with which these outcomes were implemented worldwide, finally led to the decision to publish these research findings under the umbrella of this project. The proud product is a comprehensive package of tests for three commercial antimalarial products, the outcomes of which are hoped to contribute towards the combat against resistance formation to these important disease fighters. / Thesis (Ph.D. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.

The design and selection of surface treatment binders in service is currently based on specifications that only account for the penetration and ductility of emulsion residues or the penetration and viscosity of hot-applied asphalt cements. These specifications consider neither the entire range of temperatures that the binders may be subjected to during production and in service, nor long-term aging behavior. A surface performance-graded (SPG) specification for the selection of surface treatment binders was developed as part of previous Texas Department of Transportation (TxDOT) and National Cooperative Highway Research Program (NCHRP) projects. The work performed under the TxDOT Project 0-6616 was the basis for this thesis. In this project, the SPG specification, which is performance-based and takes into account the physical properties of the binder at the temperature ranges in which the material will be used, was further validated. This was accomplished by standardizing the emulsion residue recovery method through the evaluation of two warm oven methods, exploring the exclusive use of the dynamic shear rheometer (DSR) for determining performance-based properties, and further field validating the thresholds for these properties. The laboratory and field results were used to revise the SPG specification for surface treatment binders in service. Binder samples collected from chip seal projects constructed on selected highway sections in Texas in summer 2011 were tested and graded according to the existing SPG specification developed in previous research projects. Two warm oven emulsion residue recovery methods were used and compared. New DSR tests, including the multiple stress creep recovery (MSCR) test and the frequency sweep test were evaluated for developing additional criteria in the SPG specification. The SPG grades of the surface binder samples evaluated from laboratory tests were compared with the actual field performance of the highway sections one year after construction. The SPG specification was found to be functional in terms of enabling the selection of binders to ensure adequate surface treatment performance. Moreover, the results obtained from the MSCR and DSR frequency sweep tests were compared with field performance to develop additional criteria in the specification. Further validation is recommended to investigate the effects of construction and quality control processes, as this study is limited to producing a revised SPG specification for properties that address stiffness and aggregate retention in service.

Thesis (M.S.)--West Virginia University, 1995.

Title from first page of PDF document. Includes bibliographical references (p. Xx-Xx).

Thesis (M.S. in Nuclear Engineering)--Naval Postgraduate School, January 1963. / Thesis Advisor(s): Gerba, Alex. "January 1963." Description based on title screen as viewed on June 2, 2010. DTIC Descriptor(s): Research Reactors, Control Systems, Neutron Detectors, Neutron Flux, Reaction Kinetics, Equations, Simulation, Production Reactors, Test Reactors, Computer Programming, Analog Computers, Digital Computers, Nuclear Reactions, Performance (Engineering), Specifications, Neutron Activation. DTIC Identifier(s): AGN-201 Reactors. Includes bibliographical references (p. 54-55). Also available in print.