Global ETD Search

21	Langzeitergebnisse von operativ versorgten Wirbelsäulendeformitäten bei Kindern mit Spinaler Muskelatrophie / Long-term results of surgically treated spinal deformities in children with spinal muscular atrophy Hecker, Marina Magdalena 19 November 2020 (has links) No description available. 610 Skoliose Spinale Muskelatrophie SMA MAGEC VEPTR Cobb-Winkel Pelvic Obliquity Krümmungskorrektur Spondylodese scoliosis spinal muscular atrophy SMA MAGEC VEPTR Cobb angle pelvic obliquity curve correction spinal fusion spondylodesis Medizin (PPN619874732)
22	Glial fibrillary acidic protein in cerebrospinal fluid of patients with spinal muscular atrophy Freigang, Maren, Steinacker, Petra, Wurster, Claudia D., Schreiber-Katz, Olivia, Osmanovic, Alma, Petri, Susanne, Koch, Jan C., Rostásy, Kevin, Huss, André, Tumani, Hayrettin, Winter, Benedikt, Falkenburger, Björn, Ludolph, Albert C., Otto, Markus, Hermann, Andreas, Günther, René 04 April 2024 (has links) Objective: Activated astroglia is involved in the pathophysiology of neurodegenerative diseases and has also been described in animal models of spinal muscular atrophy (SMA). Given the urgent need of biomarkers for treatment monitoring of new RNA-modifying and gene replacement therapies in SMA, we examined glial fibrillary acidic protein concentrations in cerebrospinal fluid (cGFAP) as a marker of astrogliosis in SMA. - Methods: 58 adult patients and 21 children with genetically confirmed 5q-associated SMA from four German motor neuron disease specialist care centers and 30 age- and sex-matched controls were prospectively included in this study. cGFAP was measured and correlated to motor performance and disease severity. Additionally, we compared fL). - Results: cGFAP concentrations did not differ from controls but showed higher levels in more severely affected patients after adjustment for patients’ age. Normalized cNfL values were associated with disease severity. Within 14 months of nusinersen treatment, cGFAP concentrations did not change, while cNfL decreased significantly. - Interpretation: cGFAP is not an outstanding biomarker in SMA, but might support the hypothesis that glial activation is involved in SMA pathology. Unlike previously suggested, cNfL may be a promising biomarker also in adult patients with SMA, which should be subject to further investigations. info:eu-repo/classification/ddc/610 ddc:610
23	Die Behandlung der kindlichen Skoliose bei spinaler Muskelatrophie mit extern zu kontrollierenden magnetischen Implantaten / Externally controlled magnetic implants as a treatment for infantile scoliosis in children with spinal muscular atrophy Badwan, Batoul 27 August 2018 (has links) No description available. 610 Spinale Muskelatrophie Beckenschiefstand Skoliosekrümmungswinkel (Cobb-Winkel) Infantile Skoliose Wirbelsäulendeformität wachstumsfreundliche Implantate SMA spinal muscular atrophy infantile scoliosis growing rods magnetically controlled growing rods pelvic obliquity spinal deformity scoliotic curve SMA Orthopädie (PPN619876204) Kinderchirurgie (PPN619876115)

Page generated in 0.0566 seconds