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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
191

Measurement of ionic calcium and its role in milk stability

Lin, Mei-Jen January 2002 (has links)
No description available.
192

Real-time modelling of multimachine power systems

Dale, L. A. January 1986 (has links)
No description available.
193

Characterisation of Chromatography Media Aimed for Purification of Biomolecules

Andersson, Mikael January 2014 (has links)
Chromatography media (resins) are very important for and widely used by the biopharma industry in large scale production of biopharmaceuticals, e.g. monoclonal antibodies. Today there are several hundred biopharmaceuticals released globally on the healthcare market. This thesis discusses various strategies and methods for the characterisation of chemical and functional stability of chromatography media. In addition, various analytical techniques used in these areas were evaluated and applied. Further, more specific physical and chemical characterisation methods were evaluated and applied to explore different properties of various chromatography media. In Papers I-III, established methodologies for performing chemical and functional stability studies were used. Mainly agarose-based chromatography media were investigated. For fast screening of the chemical stability, the total organic carbon analysis technique was evaluated and applied. This technique that measures the carbon leakage from the chromatography media at different conditions, proved to be very suitable and robust. For detection and/or identification of leakage compounds responsible for or for part of the measured carbon leakage, different methods such as (high performance) liquid chromatography and gas chromatography mass spectrometry were used. In Papers IV-VII, different properties (i.e. functional performance, ligand content and surface chemistry) were evaluated for different agarose-based chromatography media. Standard chromatographic methods (ion exchange chromatography) and spectroscopic methods (e.g. Fourier transform infrared spectroscopy and time-of-flight secondary ion mass spectrometry) were evaluated and applied. Chemometric methods were used for efficient evaluation of data. Information of chemical, functional and leakage data of chromatography media are valuable and important for the biopharmaceutical companies to be able to fulfil the regulatory requirements of biopharmaceuticals. In addition, information of various chemical, functional and physical properties of chromatography media is likewise important during development and set up of new biopharmaceutical processes.
194

A probabilistic key block analysis for the prediction of tunnel and stope support

Tyler, Duncan B. January 1991 (has links)
No description available.
195

A study on the analysis and the stability of anthocyanins from blackberries

Linsey, C. J. January 1985 (has links)
No description available.
196

Self-excited aerodynamic unsteadiness associated with passenger cars

Sims-Williams, David Boyd January 2001 (has links)
Passenger cars are bluff bodies and are prone to unsteady phenomena with scales comparable to the scale of the vehicle itself. This type of large-scale, self-excited unsteadiness is the subject of the present work. Aerodynamic unsteadiness can be important for two reasons. It can cause unsteady pressures and forces on the car and it can impact the time-averaged flow through the generation of Reynolds stresses. A range of parametric two-dimensional bodies have been used in the development of novel experimental techniques and analyses and for CFD validation. Detailed investigations have been undertaken on the Ahmed model and on models of a Rover 200 passenger car in wind tunnels at Durham and at MIRA at scales of up to 40%. A method was developed which makes it possible to visualise periodic flow structures from measurements made sequentially in the wake or on the model surface. Unsteady flows for fastback passenger cars were found to be much less periodic than for two-dimensional vortex shedding cases. Pressure fluctuations were significantly lower on the model surface than in the wake resulting in limited unsteady forces. Unsteady flow structures, Strouhal numbers and levels of unsteadiness were similar for the Rover 200 model with and without a backlight spoiler and for the Ahmed model, indicating that sharp corners do not have a dominant effect on unsteadiness. Two principal unsteady structures were observed in the wake of the fastback shapes. A structure was observed at Strouhal numbers around 0.1 involving the alternate strengthening of the two c-pillar vortices in an antisymmetric mode. At Strouhal numbers in the range 0.3 to 0.6 an unsteady structure was observed consisting of the oscillation of the strength of the two c-pillar vortices in a symmetric mode. At the same time the location of the vortices oscillates in the vertical direction.
197

Quantification of spine stability: Assessing the role of muscles and their links to eigenvalues and stability

Ikeda, Dianne Miyako January 2011 (has links)
Approximately 50% - 80% of the population will experience disabling low back pain at some point in their life. Assessing and developing interventions based on “lumbar stability” and/or joint stiffness to reduce low back pain has been a common research focus. Specific focus has been on identifying which muscles influence lumbar stability/stiffness, with one argument being between focusing training on the transverse abdominis and lumbar multifidus muscles versus broader training approaches involving the entire abdominal wall and erector spinae muscles. However, there has not been research on whether pain reduction was due to increased stability/stiffness or another mechanism. The main goals of this thesis were to determine the effect of individual muscles on stability/stiffness through a two phase process. In the first phase, a model sensitivity analysis was performed to assess the interactions of variables that influence the quantification of stability. Stability was quantified via the eigenvalues (EV) of the Hessian matrix of potential energies at each lumbar level and axis of rotation, for a total of 15 EVs (3 axes of rotation x 5 joints). In phase 2, assessment of clinical interventions on patients with low back pain designed to alter biomechanics was conducted to assess factors in stability/stiffness quantification and mechanisms of action in pain modulation. More detail of the study phases are described below, in order to test the following hypotheses: 1) It was hypothesized that individual muscles affect specific EVs, but no one muscle can be associated with one EV level. 2) It was hypothesized that specific muscles do affect specific planes of stability/stiffness. 3) It was hypothesized that EVs are affected by posture. 4) It was hypothesized that overactivating muscles by increasing muscle activation to 100% MVC negatively affects the EVs. 5) It was hypothesized that the relationship between muscles and specific EVs obtained during simulation remains with real subjects performing loaded tasks. 6) It was hypothesized that coaching and cueing specific movement patterns and motor patterns would alter pain in low back pain patients. 7) If hypothesis 6 is true, then it was hypothesized that changes in pain would be reflected in changes in EVs. Methods for Phase 1 The first phase involved a sensitivity analysis using an anatomically detailed spine model. Theoretical data including posture, motion and muscle activity were synthesized to include 23 static spine postures, including neutral, 0° - 50° flexion, 0° - 30° extension, 0° - 30° right and left lateral bend, and 0° - 40° right and left axial twist, all in increments of 10°. For each posture, all eleven muscles included in the model, some with several fascicles, were artificially activated to 50% MVC. A knockout approach ensued whereby activity in single muscles were systematically reduced to 0% MVC or increased to 100% MVC. The relationships between the 15 EVs and the changes in muscle activity and posture were assessed. This muscle knockout model was repeated with actual muscle activity values obtained from electromyographic (EMG) signals and postures obtained from four subjects who performed a walking task with a 15 kg load in each hand. Results for Phase 1 The sensitivity analysis showed that the abdominal muscles contribute a greater stabilizing effect on the L4 and L5 EVs, while the multifidus and erector spinae muscles contribute a greater effect on the L1, L2 and L3 EVs. When examining the effect of muscles on a specific plane in terms of influencing stability/stiffness, it was found that the abdominal muscles contribute a greater effect on the bend axis and twist axis EVs than the flexion axis EVs, while the erector spinae muscles contribute the greatest effect on the flexion axis EVs. Posture was found to have a biologically significant effect on EVs, with the 50° flexion and 30° extension postures having the most detrimental effect in terms of compromising stability/stiffness. In addition, when there was a 10° excursion in any axis, there was little change in the EVs, while postures at angles greater than this were often associated with decreases in stability/stiffness in some EVs. Increasing the muscle activation from 50% MVC to 100% MVC did not have a large effect on most EVs, but when there was a meaningful change, as defined by a change of 10% or greater in the EV, the 100% MVC activation level always resulted in more stability/stiffness at that particular EV. Finally, using actual EMG and lumbar angle patterns resulted in similar results as the theoretical data, as expected. Interpretation of these findings is limited by the following. Even though EVs changed, there is no guarantee that the magnitude of change in one EV could be interpreted to equal a similar magnitude of change in another EV, nor may it be assumed that EVs have a linear relationship with stability/stiffness. These results suggest that when the goal is to increase lumbar stability, a neutral spine should be maintained and activating the larger abdominal muscles is more important than activating the transverse abdominis or multifidus, as proposed by some clinical groups. Methods for Phase 2 Four case studies of individuals with chronic low back pain were recruited from whom kinematic, kinetic and EMG data were collected in addition to a measure of pain intensity using an 11-point verbal numerical rating scale. Pain provocation tests were performed by a clinician (professor Stuart McGill) to identify the motions, postures and loads that exacerbated their pain. Then these tasks were repeated while the motion and EMG data was collected. This was followed by interventions coached by the clinician that could include the abdominal brace (stiffening the abdominal wall), latissimus dorsi stiffening, incorporating a hip-hinge motion rather than spine bending, or any combination of these. The intention of the intervention was to immediately reduce pain intensity. These tasks arranged in a repeated measures design were assessed with the anatomically detailed spine model to calculate stability/stiffness from evaluation of the 15 EVs, lumbar compression and lumbar shear forces. Results for Phase 2 The results from phase 2 suggest that pain was sometimes reduced by altering motions, postures and load, but the mechanism of what proved effective and the degree of success was variable from patient to patient. In most situations, the EVs, lumbar compression forces and lumbar shear forces increased due to the intervention that was chosen. In addition, the lumbar flexion angle typically trended to a more neutral posture and in tasks where spine motion occurred, there was less spine motion when using the suggested intervention. Further, the biomechanical variable that would be expected to change based on clinical assessment did not always react in the expected way (i.e. a compression intolerant individual would be expected to have decreased compression linked with decreased pain, but this did not occur). While the stability/stiffness increased, the associated compression was tolerated suggesting that the increase in concomitant stiffness enhanced the compression load bearing tolerance. Overall Conclusions This thesis showed that careful examination of the EVs did not offer substantial insight into links between changes in individual EVs and individual muscles, as muscle activity was not reflected in the EVs. Specifically, single muscles contributions were not reflected in specific EVs as was hypothesized. Further, it was difficult to interpret the EVs collectively because of the inherent non-linearity between EV magnitude and changes in muscle activation/stiffness; it can only be said that there was more or less stability/stiffness with each change in an EV, not how much. In addition, pain reduction appeared to be due to a combination of altered motions, postures and loads, but this did not result in systematic EV changes. Globally, the present work provides evidence supporting the idea that maintaining a neutral posture and activating the abdominal muscles results in less pain and larger EVs, suggesting an increase in stability/stiffness. This work has potential for informing clinicians on possible options for immediate reduction in low back pain.
198

Some aspects of stability in nonlinear programming

Wolkewicz, Gail S. K., 1950- January 1978 (has links)
No description available.
199

Forecasting instability indicators in the horn of Africa region

Tannehill, Bryan R. January 1900 (has links) (PDF)
Thesis (M.S.)--Air Force Institute of Technology, 2008. / AFIT/GOR/ENS/08-21. Title from title page of PDF document (viewed on: Mar. 31, 2008). "March 2008." Includes bibliographical references (leaves [257-263]).
200

Forecasting instability indicators in the horn of Africa region

Tannehill, Bryan R. January 1900 (has links) (PDF)
Thesis (M.S.)--Air Force Institute of Technology, 2008. / AFIT/GOR/ENS/08-21. Title from title page of PDF document (viewed on: Mar. 31, 2008). "March 2008." Includes bibliographical references (leaves [257-263]).

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