本碩士論文裡的研究主要設計用來檢測目前現有的國際化理論，以依據公司1970至1999年的母公司年報來研究一間多國企業的藥廠 — 必治妥施貴寶其部分具有知名度的代表性產品之國際化路徑如此的研究方法。本論文的最終目標就是透過這樣的實務研究來回答以下問題來挖堀出現有國際化理論的一些缺口及提供寶貴的意見來修正這些缺口，研究問題如下： i. 一間多國企業藥廠通常採用何種進入策略，而這些策略是否會隨著時間而改變？是否有任何經驗傳承的證據？ ii. 多國企業所選擇進入的外國市場是否會隨著時間的改變而改變？如果有，是否一間多國企業會先選擇進入與其母國文化較相近或地理位置較相近的國家？ iii. 哪一個國際化理論比較適合用來描述必治妥施貴寶其國際化路徑？ 本研究的結果有以下四項重要的發現： 1. 在某些國家的進入策略的改變是循序漸進的，但是在某些國家則是有同時間採用兩種以上不同的進入策略。 2. 循序漸進進入策略的改變在九十年代必不明顯。 3. 必治妥施貴寶所選擇進入的外國市場會隨著時間的改變而改變，而且其新產品會選擇與其母國美國文化距離較近的國家先進入，然後再慢慢的選擇進入離美國文化距離較遠的國家。但是這樣的證據並不是相當明顯。其他的因素也會影響一家多國企業在國外市場選擇的決定。 4. 部分結果顯示出一些經驗傳承的現象，在九十年代必治妥施貴寶所開發出的產品相對於八十年代所開發出的產品在全球上市所花的時間明顯較短。 結論就是本研究結果有部分與循序漸進理論為主的國際化理論 – ‘The Stages Internationalization Theory’一致，此理論主張國際化是一種循序漸進對於國際市場知識的累積及資源的投入。部分結果則顯示出此理論尚有其不足之處。此理論是在七十年代被Johanson及Vahlne兩位學者所提出，當時的國際企業環境與現在比起有相當大的差異，因此此理論在某種程度上太過簡化，而且並不適用於所有的產業。有許多會影響某企業其國際化路徑的因素應該一併納入，尤其在面對像製藥產業如此特別的產業，因素例如不同國家的製藥產業法規、產品特性、專利保護、在不同時間點的國際企業環境都會影響企業的國際化路徑的發展。因此後續與本碩士論文類似的實務研究需要更充分的資料來檢測現有國際化理論的主張。 / This Master thesis is designed to test the currently existing internationalization theory by studying the internationalization processes of some of the representative products of a foreign multinational pharmaceutical firm – The Bristol-Myers Squibb using the data contained in the annual reports of the period from 1970’s to 1990’s. By answering the following questions, the ultimate goal is to provide useful suggestions that will help to make corrections to any possible flaws in the Internationalization theory as they are uncovered during the course of this study by answering the following questions: i. What entry modes to foreign markets does a multinational pharmaceutical firm adopt and do entry modes change over time? Is there any sign of experience transfer? ii. Do foreign markets served by a multinational pharmaceutical firm also change over time? iii. Which theory depicting the internationalization process of firms is more applicable to Bristol-Myers Squibb? The results of the analysis of the data show four important findings: 1. Progressive changes in entry modes took place in certain countries and the employment of multiple entry modes was also observed. 2. The progressive changes in entry mode were barely observed during the 1990’s. 3. The choices of foreign markets did change over time and the marketing activities of new products tended to commence in countries that are the most culturally proximal from the U.S., and then gradually shifted to countries that are more culturally distant from the U.S. However, other factors might also influence a firm’s choice in the foreign markets apart from culture. 4. There seemed to be a sign of experience transfer since the some of the results showed that the time it took to introduce a product developed in the 1980’s in foreign markets was relatively shorter than the time it took to launch a product of the 1990’s. In conclusion, the results of study were partly consistent with ‘The Stages Internationalization Theory’ which argued that the internationalization was a process of knowledge accumulation of foreign markets and resource commitment gradually. However, there might be some flaws in the theory which needed to be refined. The theory was developed in the 70’s and it might not be perfectly applicable to describe the internationalization processes of the firms in every industry. It should also take other factors apart from culture into considerations such as the nature of products, regulations and policies of different countries, competitive scope of the industry or the international business environment at different time points, especially when dealing with some special industries such as that of the pharmaceuticals in which regulations of different countries, patent protection and the nature of the products might influence the pattern of internationalization of the firms. However, further empirical studies with more adequate data would be necessary in the future in order to justify the propositions of different theories of internationalization.

This study begins with a discussion of step theory. Included in this discussion is the basis of chord succession, the idea of fundamental representation, and the uses of reinterpretation technique. These concepts are then used to demonstrate the continuity and logic of the harmonic language found in Strauss's Macbeth.

Unsatisfactory results for the aim of reducing suicide rates have motivated the creation of new models to predict suicide, such as the ideation-to-action framework, which focuses on differentiating those with suicidal ideation and those who attempt suicide. The most recently published theory on the ideation-to-action framework is the Three-Step Theory (3ST). Step 1 proposes that the combination of pain and hopelessness causes suicidal ideation, step 2 proposes that ideation increases when pain and hopelessness surpass connectedness, and step 3 proposes that strong suicidal ideation escalates to action when the person has the capacity to attempt suicide. The theory’s concepts are intentionally conceptualized very broadly. The current study aims to compare the traditional conceptualization measurements of the Three-Step Theory with a broader range of predictors. We aim to test the first two steps of the theory through a mediation model and examine if connectedness serves as a mediator in the relationship between psychological pain and hopelessness in predicting the severity of suicidal ideation. We hypothesized that adding a broader conceptualization of pain (i.e., physical pain) and connectedness (i.e., perceived meaning of life, social pleasure, affective empathy) will better account for the level of suicidal ideation. We also hypothesized that connectedness serves as a mediator in the relationship between psychological pain and hopelessness in predicting suicide ideation severity. Following exclusions and removing missing data, 97 participants were available for analysis. Results showed that one of our novel measurements of connectedness, perceived burdensomeness, mediated the relationship between psychological pain and suicidal ideation severity.

The major objective of this empirical research is to identify and explain the level of regional development and analyse the challenges of policy implementation with special focus on Tigray and Gambella Regions from 1995 to 2015. In line with the research objectives and statement of the problem, this study was designed to determine the level of development of the two regional states, the critical factors of regional growth in the regions, and what the major challenges were in the implementation of regional development policy. This research was explanatory cross-sectional in its design. In this research, both primary and secondary sources were consulted. Key informant interview, document review and observation were used to collect the necessary information. Accordingly, based on their expertise knowledge, and the position they held, a total of 24 regional and federal key informants were purposively selected and interviewed. The findings of the study showed that both regions made remarkable improvements and changes in health, education, road network, agricultural and revenue collection performance. However, contrary to the perceptions of the respondents, the secondary data when divided by regional population showed that in the past 20 years Gambella has been better off in terms of health, education, road networks and some agricultural indicators than Tigray. Tigray, however, grew more in terms of infrastructure than Gambella during the same period. The study found that the Government regional development policy designed and implemented as measured by growth-oriented indicators brought encouraging results. The most important determinant factors for regional economic development between the two sampled regions were: initial historical level of development; capacity of resource utilisation; leadership commitment, cultural differences, recurrent conflicts and insecurity, governance issues, political will, capacity of the regional government authorities; and rent-seeking attitude of politicians and civil servants. To address some of the challenges, few recommendations are made: designing a regional specific development policy, strengthening intergovernmental relations, protecting the environment, ensuring good governance, maintaining peace and security, strengthening capacity building, supporting infrastructural development for Gambella and the provision of additional financial incentives to regions. / Development Studies / D. Litt. et Phil. (Development Studies)

This work concerns the interrelationship between thermodynamic, kinetic and structural aspects of crystal polymorphism. It is both experimental and theoretical, and limited with respect to compounds to substituted monocyclic aromatics. Two polymorphs of the compound m-aminobenzoic acid have been experimentally isolated and characterized by ATR-FTIR spectroscopy, X-ray powder diffraction and optical microscopy. In addition, two polymorphs of the compound m-hydroxybenzoic acid have been isolated and characterized by ATR-FTIR spectroscopy, high-temperature XRPD, confocal Raman, hot-stage and scanning electron microscopy. For all polymorphs, melting properties and specific heat capacity have been determined calorimetrically, and the solubility in several pure solvents measured at different temperatures with a gravimetric method. The solid-state activity (ideal solubility), and the free energy, enthalpy and entropy of fusion have been determined as functions of temperature for all solid phases through a thermodynamic analysis of multiple experimental data. It is shown that m-aminobenzoic acid is an enantiotropic system, with a stability transition point determined to be located at approximately 156°C, and that the difference in free energy at room temperature between the polymorphs is considerable. It is further shown that m-hydroxybenzoic acid is a monotropic system, with minor differences in free energy, enthalpy and entropy. 1393 primary nucleation experiments have been carried out for both compounds in different series of repeatability experiments, differing with respect to solvent, cooling rate, saturation temperature and solution preparation and pre-treatment. It is found that in the vast majority of experiments, either the stable or the metastable polymorph is obtained in the pure form, and only for a few evaluated experimental conditions does one polymorph crystallize in all experiments. The fact that the polymorphic outcome of a crystallization is the result of the interplay between relative thermodynamic stability and nucleation kinetics, and that it is vital to perform multiple experiments under identical conditions when studying nucleation of polymorphic compounds, is strongly emphasized by the results of this work. The main experimental variable which in this work has been found to affect which polymorph will preferentially crystallize is the solvent. For m-aminobenzoic acid, it is shown how a significantly metastable polymorph can be obtained by choosing a solvent in which nucleation of the stable form is sufficiently obstructed. For m-hydroxybenzoic acid, nucleation of the stable polymorph is promoted in solvents where the solubility is high. It is shown how this partly can be rationalized by analysing solubility data with respect to temperature dependence. By crystallizing solutions differing only with respect to pre-treatment and which polymorph was dissolved, it is found that the immediate thermal and structural history of a solution can have a significant effect on nucleation, affecting the predisposition for overall nucleation as well as which polymorph will preferentially crystallize. A set of polymorphic crystal structures has been compiled from the Cambridge Structural Database. It is found that statistically, about 50% crystallize in the crystallographic space group P21/c. Furthermore, it is found that crystal structures of polymorphs tend to differ significantly with respect to either hydrogen bond network or molecular conformation. Molecular mechanics based Monte Carlo simulated annealing has been used to sample different potential crystal structures corresponding to minima in potential energy with respect to structural degrees of freedom, restricted to one space group, for each of the polymorphic compounds. It is found that all simulations result in very large numbers of predicted structures. About 15% of the predicted structures have excess relative lattice energies of <=10% compared to the most stable predicted structure; a limit verified to reflect maximum lattice energy differences between experimentally observed polymorphs of similar compounds. The number of predicted structures is found to correlate to molecular weight and to the number of rotatable covalent bonds. A close study of two compounds has shown that predicted structures tend to belong to different groups defined by unique hydrogen bond networks, located in well-defined regions in energy/packing space according to the close-packing principle. It is hypothesized that kinetic effects in combination with this structural segregation might affect the number of potential structures that can be realized experimentally. The experimentally determined crystal structures of several compounds have been geometry-optimized (relaxed) to the nearest potential energy minimum using ten different combinations of common potential energy functions (force fields) and techniques for assigning nucleus-centred point charges used in the electrostatic description of the energy. Changes in structural coordinates upon relaxation have been quantified, crystal lattice energies calculated and compared with experimentally determined enthalpies of sublimation, and the energy difference before and after relaxation computed and analysed. It is found that certain combinations of force fields and charge assignment techniques work reasonably well for modelling crystal structures of small aromatics, provided that proper attention is paid to electrostatic description and to how the force field was parameterized. A comparison of energy differences for randomly packed as well as experimentally determined crystal structures before and after relaxation suggests that the potential energy function for the solid state of a small organic molecule is highly undulating with many deep, narrow and steep minima. / QC 20110527