Thesis (Ph.D.)--Aberdeen University, 2008. / Title from web page (viewed on Feb. 23, 2009). With: Natural disordered sequences in the amino terminal domain of nuclear receptors : lessons from the androgen and glucocorticoid receptors / Iain J. McEwan ... et al. Nuclear Receptor Signalling. 2007: 5. Includes bibliographical references.

Thesis--University of Wisconsin--Madison. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 94-109).

Cryopreservation is a technique used to store cells and tissues for long time. It requires the addition of a cryoprotectant, which prevents damage to cells caused by the formation of large ice crystals. Few compounds have been classified as cryprotectants, and some of them are very toxic like DMSO. Our lab is interested in the synthesis of small, non-toxic cryoprotectants that possess ice recrystallization inhibition (IRI) activity. Much attention has been drawn towards small molecules that contain an amine group because they have some activity towards inhibiting ice recrystallization. Herein we have examined few monoamine and diamine molecules as well as PAMAM dendrimer for IRI activity. Some of the small molecules tested contain an aryl ring, and we found that changing the position of groups around the ring can have some impact in the IRI activity. We have also found that increasing the number of amines in a molecule can have little effect of the IRI activity. It is hoped that these findings can open new doors for further investigation in small amino molecules and the development of novel cryoprotectants. Corticosteroids were first identified and isolated from both teleost and elasmobranch fish. Corticosterone and cortisol were measurable in the plasma of elasmobranchs and 1α-hydroxycorticosterone (1α-OH-B) was the dominant corticosteroid produced by the internal tissue. Limited amount of 1α-OH-B was synthesized because available supplies were exhausted in the early 1990s. Synthetic 1α-OH-B was used in steroid receptor studies to examine the evolution of the corticosteroid receptor system and measure stress levels.

Thesis (M.Phil. Chemistry)--University of Waikato, 2006. / Author held a Georgetti scholarship. Includes bibliographical references (leaves 89-99). Also available via the World Wide Web.

Thesis (MTech (Biomedical Technology))--Cape Technikon,1997. / The aims of this study were to measure: 1. Myometrial cells of menopausal uteri to establish whether they atrophy after the menopause. 2. Myometrial cells at different phases of the menstrual cycle to investigate the influences of oestrogen and progesterone during the cycle. 3. Myometrial cells in the fundus and lower uterine segment to establish whether they differ in size. 4. Myometrial cells of pregnant uteri to investigate the effect of the hormonal status of pregnant women on the size of myometrial cells. 5. Neoplastic cells of leiomyomas of the uterus to investigate whether these benign tumours behave in the same manner as myometrium or, because they are neoplastic, they react differently. A preliminary investigation was undertaken to establish the optimal methodology for this study to measure myometrial and leiomyoma nuclei in the uterus. The aims of this preliminary investigation were: 1. To test the reproducibility of measurements of myometrial and leiomyoma nuclei in transverse and cross section. 2. To test five histological staining methods to ascertain the best method for a morphometric study on uterine cells. 3. To find the minimum sample size of nuclei per section of myometrium or leiomyoma in order to yield statistically significant results. This preliminary study found that the Haematoxylin and Eosin stain gave the most statistically reproducible measurements. Subjective assessment of the five staining methods also found Haematoxylin and Eosin to be optimal. It was also found during the preliminary study that measuring the myometrial nuclei in cross rather than transverse section gave the most statistically reproducible measurements. It was also found that it was best to use an axial ratio criterion of 0,9 when measuring cross-sectioned myometrial nuclei. The optimum sample size per section was also investigated and it was found that measuring 100 nuclei was optimal. It was found that in the uteri used in this study there was no statistically significant decrease in nuclear size after the menopause. It was also found that there was no statistically significant difference in nuclear size during the different phases of the menstrual cycle. There was also no notable difference in nuclear size between nuclei in the fundus and lower segment of the uteri in this study. It was found that there was a significant increase in the size of nuclei in leiomyomas compared to the normal myometrial nuclei from the same patient. The myometrial nuclei from pregnant uteri were also significantly larger than those from non-gravid uteri.

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