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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Einfluss des eNOS T-786C-Polymorphismus auf die 5-Jahres-Mortalität und -Morbidität von Patienten nach herzchirurgischen Eingriffen / The eNOS T-786C gene polymorphism and its influence on 5-year mortality and morbidity after on-pump cardiac surgery

Bireta, Christian 14 April 2015 (has links)
No description available.
2

A reusable material with high performance for removing NO at room temperature: performance, mechanism and kinetics

Lu, Pei, Xing, Yi, Li, Caiting, Qing,†, Renpeng, Su, Wei, Liu, Nian 07 January 2020 (has links)
Removing NO from the air with a reusable material at room temperature is challenging. In this study, a series of urea–MnOₓ/ACF and urea–x(CeO₂–(1 − x)MnO₂)/ACF materials were prepared and used for removing NO at room temperature. The results showed that 10% urea–8% (0.5CeO₂–0.5MnO₂)/ACF yielded the highest NO conversion, which showed an NO conversion ratio above 90% with 1000 ppm NO in the initial mixed gases. Moreover, the NO conversion exceeded 98% when the NO concentration was 100 ppm in the initial mixed gases. More importantly, 10% urea–8% (0.5CeO2–0.5MnO₂)/ACF was stable even after it was regenerated by reloading with urea, demonstrating that the material could be easily reused and its highperformance was maintained. Finally, the mechanism and kinetics of the NO removal was discussed.
3

Taking NO for an answer: NO modulation of BMP2 signalling and osteoinduction (English)

Differ, Christopher 07 December 2018 (has links)
Das Bone Morphogenetic Protein 2 (BMP2) gehört zur TGF-beta Superfamilie und findet seinen Fokus in der osteogenen Aktivierung und in der Anwendung bei der Frakturheilung. Es wird angenommen, dass weitere, bisher unbekannte Verbindungen existieren, die die BMP2-Signalübertragung und die osteogene Aktivität verbessern und somit zu einer verbesserten klinischen Wirksamkeit von BMP2 führen. Für den Stickstoffoxid (NO)-Signalweg ist bereits bekannt, dass im endothelialen Kontext eine Verbindung zum BMP2-Signalweg existiert. Ziel dieser Arbeit war es daher, eine Verbindung zwischen dem NO- und BMP2-Signalweg bezüglich der Regulierung des BMP2-abhängigen Signalwegs und der Osteoinduktion aufzuzeigen. Dies erfolgte durch Anwendung von Inhibitoren (LNAME, ODQ und LY83583) und Aktivatoren (L-Arginin, Deta NONOate, SNAP und YC-1) des NO-Signalwegs, in Kombination mit BMP2. Eine mögliche Verbindung zwischen dem BMP2- und NO-Signalweg, über eine Protein Kinase A (PKA) Brücke, wurde durch die Anwendung des PKA Inhibitors H89 untersucht. Zusammenfassend zeigen diese Ergebnisse, dass der NO-Stoffwechselweg den BMP2-vermittelten Signalweg und die osteoinduktive Aktivität modulieren kann, wobei PKA beide Signalwege im Rahmen der BMP Signalübertragung verbindet, jedoch nicht zu einer BMP2-vermittelten Osteoinduktion führt. / Bone Morphogenetic Protein 2 (BMP2) is a TGF-beta superfamily member, with a major focus on osteogenic activity and application in fracture healing. In order to improve efficiency of BMP2 in the clinic, it is assumed that additional, yet unknown compounds can improve BMP2 signalling and osteogenic activity. The Nitric Oxide (NO) pathway has previously shown to be connected with the BMP2 pathway in an endothelial context. Therefore, it was the aim of this study to unravel connections between the NO and BMP2 pathway in regulating BMP2 mediated signalling and osteoinduction. This was carried out through the application of inhibitors (LNAME, ODQ and LY83583) and activators (L-Arginine, Deta NONOate, SNAP and YC-1) of the NO pathway in combination with BMP2. A proposed connection between BMP2 and NO pathways via a Protein Kinase A (PKA) bridge was investigated by application of H89 inhibitor. In summary, these results show that the NO pathway can modulate BMP2 mediated signalling and osteoinductive activity. The PKA bridge connects NO and BMP2 only for the process of BMP2 signalling, but not for BMP2 mediated osteoinduction.
4

Einfluss des eNOS-G-894-T-Polymorphismus auf die 5-Jahres-Mortalität und-Morbidität kardiochirurgischer Patienten / The eNOS 894 G/T gene polymorphism and its role on 5-year-mortality and- morbidity after on-pump cardiac surgery.

Lipke, Christina 14 April 2015 (has links)
No description available.

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