Aircraft structural layout concept design at Saab Aeronautics utilize thickness optimizationto evaluate astructural layout concept. The thickness values can be used to compare conceptsto each other,and the bestonecan be further developed. Today, most ofthe creation and evaluation of structural layout concepts is manual work. Therefore, there is an ongoing investigation on how to implement design automation to reduce this manual and repetitive work. The investigationaims to achieve rapid exploration of the design space to find a good base for a new aircraft development. This includes investigating how the synchronization between a structural layout model (SLM) and a global finite element model (GFEM) can be improved. This thesis contributes to the investigation by exploring the possibilities to implement design automation in the creation of the SLM regarding the fuselage structure. Further, exploring the implementation of design automation in the creation of the GFEM to enable automatic evaluation of concepts. The thesis also explores how the synchronization between the models can be improved. To structure the thesis work, the software development methodologies of MOKA and RAD weremodified and combined. The execution of the thesis was carried out in the software of 3DEXPERIENCE, particularly using the applications CATIAand SIMULIA. This thesis work resulted in a methodfor developing and evaluating aircraft structure concept designs with design automation. The new method includes two models with corresponding scripts. The first model developed is a tool for a conceptualdesignerthat enables the creation of aircraft fuselage SLM from user defined inputs. The second model is generated by script which results in a GFEM with a direct connection to the SLM. To conclude, the developed method enables a faster iteration work of fuselage structural concept designs compared to the current method. The detail level is lower but more consistent and uniform. The GFEM was not able to fulfil its purpose in the developed method due to time limits and software limitations. However, the synchronization between the SLM and GFEM was implemented successfully and contained all critical elements.