No description available.

This study was designed to explore the cognitive-perceptual roots of attrition from substance abuse treatment. Previous research on interpersonal issues among substance abusers and attachment theory suggested areas for investigation: the perception of early parental care, current interpersonal functioning, and perception of the substance abuse treatment program.

The purpose of this exploratory study was to investigate the differences between dependent personality characteristics and clinical symptomology as measured by the MCMI-II, in three major psychiatric syndromes in inpatient and outpatient treatment settings. Results show differences in profile in all groups. Treatment setting differences show higher scores on alcohol and drug dependence and major depression for inpatients. The affective group exhibited higher scores on dependent personality, dysthymic and major depression, confirming previous research on depressive disorders and dependent personality.

No description available.

Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 μM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation with no change in maximum (KB=5.3×10-8 M). Bolus injections of 0.25 to 250 pmol spantide had no effect, but higher doses caused a brief vasodilation followed by a larger, more prolonged vasoconstriction. Histamine produced similar changes in perfusion pressure. Antihistamines (H1 and H2) reduced or blocked responses to spantide and histamine. These findings indicate spantide is a competitive antagonist to SP in guinea pig coronary resistance vessels. In addition, high doses of spantide can cause prominent vascular effects which are mediated by histamine.

The Substance Abuse Subtle Screening Inventory (SASSI) is a 10 scale indirect screening instrument used to detect substance use disorders. The current meta-analytic study described reliability reporting practices across 48 studies involving the SASSI. Reliability generalization methods were then employed to evaluate typical score reliability for the screening measure. Results showed approximately 73 of studies did not report reliability estimates. Analysis of data from the remaining studies revealed adequate reliability for the total scale (α .87) and face valid scales (FVA α .88 and FVOD α .92), but substantially lower reliability estimates for the indirect scales (range of α .23.65). The study's findings underscore the need for improved reliability reporting for the SASSI and suggest cautious use of the measure, especially its indirect scales, as an indicator of problematic substance use/abuse in clinical settings.

Philosophiae Doctor - PhD / Substance abuse among adolescents is a Public Health concern globally with approximately 25 million adolescents (aged 13-15 years) who smoke tobacco, one in every ten girls and one in every five boys. In low- and middle-income countries, 14 % of girls and 18% of boys (13-15years old) are engaged in alcohol use. The Global Status Report on Alcohol and Health of 2018, reports that among the 15- to 19-year-olds, greater than a quarter were current alcohol drinkers. Cannabis (marijuana/dagga) is highly used globally with approximately 3.8% between 15 and 64 years, about 188 million people used it once or more times in 2017. The most commonly abused substances are alcohol, tobacco, and cannabis (marijuana/dagga). In South Africa, most adolescents are found in schools and the average age of drug experimentation is 12 years with early onset of use at about ten years of age.

Substance use disorders are a prominent issue within the United States that must be addressed given the high prevalence, economic cost, and negative health consequences of these medical conditions. Current treatments are inadequate due to the limited success of behavioral therapies and the lack of pharmacological interventions geared towards preventing the neuroplastic changes initiated by substances of abuse that lead to addiction. Sigma-1 receptors represent promising pharmacological targets for treatment of substance use disorders involving cocaine and methamphetamine use. A review of recent studies suggests that sigma-1 receptors contribute to the underlying mechanisms of action utilized by cocaine. Yet the use of sigma-1 receptor antagonists shows promising results of mitigating the physiological effects induced by cocaine. In contrast to cocaine, sigma-1 receptors have yet to be linked to the underlying mechanisms of action utilized by methamphetamine. However studies indicate that the use of sigma-1 receptors agonists creates a neuroprotective effect against the physiological effects induced by methamphetamine. Currently the pharmacological targeting of sigma-1 receptors is not utilized to treat substance use disorders. A review of literature was conducted in order to elucidate the mechanistic role that sigma-1 receptors play in mediating the physiological effects induced by cocaine and methamphetamine that lead to addiction. Using this information, the potential use of sigma-1 receptors as therapeutic targets was discussed in order to provide insight about the benefits and limitations of utilizing such an intervention as treatment for substance use disorders involving cocaine and methamphetamine use.

Submitted in fulfillment of the requirements for the degree Doctor of Education in the Department of Educational Psychology in the Faculty of Education at the University of Zululand, South Africa, 2006. / The aim of this study was to investigate the effect of substance abuse by senior primary school learners on their development This was achieved via a literature study and an empirical study. In the light of the findings certain recommendations which can assist educators, principals, parents and the Department of Education to plan and take action in order to combat drug abuse and addiction amongst senior primary school learners, were formulated. Schools have always had and will always have significant influence on learners' lives and must therefore be the focus of any effective implementation of arresting strategies. The senior primary school community has in the past and to a certain extent in the present not treated the increasing use of drugs as a priority. This could possibly be because of the many types of legitimate drugs that are available, and which are said to cure, prevent or slow down-diseases and enable people to lead longer, healthier and happier lives. Antibiotics have improved the treatment of infections and vaccines have prevented the spread of diseases such as measles, while analgesics have lessened or eliminated pain. However, it should be the harmful and illegal drugs that parents and the community should be made aware of. Illegal and harmful drugs infiltrate all levels of society, asking no name, title or gender. They come in many names and forms and they will negatively impact on health, sanity, families and finally people's lives. The literature study found that substance abuse affected the physical, psychological (cognitive and affective), social and normative development of the senior primary school learner. For the purpose of the empirical investigation, a self-structured questionnaire for educators was utilized. The data obtained from the completed questionnaires was processed and analyzed by means of descriptive statistics. The findings

The United States is in the midst of an opioid crisis, with more than 130 people dying each day from an opioid overdose (Centers for Disease Control and Prevention [CDC], 2018a). Given the recent spike in overdose deaths associated with highly potent synthetic opioids (i.e., fentanyl), there are few signs of the crisis abating (CDC, 2018a). Compared to other age groups, the prevalence of both heroin and prescription opioid use is particularly elevated among young adults (Sharma, Bruner, Barnett, & Fishman, 2016). While there is a large body of evidence demonstrating the effectiveness of substance use treatment in general, only 40-60% of individuals remain abstinent in the year following treatment (McLellan, Lewis, O’Brien, & Klebler, 2000). Less attention has been given to the process of treatment, making it challenging to determine what works and what needs improvement. This information is necessary in developing a comprehensive understanding of the treatment process, which in turn, will inform treatment decisions and improve client outcomes. The current study adds to existing literature by assessing during-treatment change on four proximal outcomes measuring substance-related cognitions (i.e., abstinence self-efficacy and commitment to sobriety) and self-concept (i.e., internalized shame and self-compassion). It was hypothesized that participants would demonstrate significant changes in the favorable direction on all four proximal outcomes. A sample comprised of primarily young adults with opioid use disorders attending short-term residential substance use treatment were enrolled in a naturalistic longitudinal study and assessed at intake, mid-treatment, and discharge. Individual growth curve models were used to examine change over time at both the aggregate and individual levels on the four proximal outcomes. Several potential moderating influences (e.g., demographic information, substance use history, mental health symptoms) were explored to better understand initial status and responses to treatment. Results revealed significant changes in the expected direction on all four proximal outcomes. In addition, several variables emerged as significant predictors of initial status and rates of change. These results provide further evidence that residential substance use treatment is not only a viable option in reducing substance use, but also impacts other important outcomes relevant to clients’ functioning and overall well-being.