Introduction: Currently there are approximately 1.2 million people in the United States living with HIV and it is estimated that 25.6% of HIV-positive adults suffer from depression. The purpose of this study is to examine the contribution of depression on substance use and medication adherence specifically among HIV-positive adult Georgians receiving medical care for HIV. Methods: Secondary data with a probability sample of 608 HIV-positive adults who took part in the 2009-2012 Georgia Medical Monitoring Project (MMP) were analyzed. Descriptive analysis and multivariate logistic regression models were conducted to assess relationships between depression with current cigarette smoking, injection drug use, other non-injection drug use, and medication adherence, adjusting for sociodemographic covariates (age, gender, race, and education). All analyses accounted for non-response and complex sampling design and were performed using SAS 9.2 (Cary, NC). Results: Among HIV-positive adults in Georgia, approximately 9.2% met the criteria for major depression; 15.2% of women and 6.9% of men had major depression. Heterosexual adults also had a higher percentage of major depression (11.9%) compared to adults who identified as bisexual (8.3%) or homosexual (6.1%). Major depression was also highest among young adults (17.1%) and adults with high school diploma or GED (13.0%). Major depression was associated with a greater odds of current cigarette smoking (3.04; 95% CI: 1.48, 6.23); injection drug use (5.62; 95% CI: 0.96, 32.81), and other non-injection drug use (2.17; 95% CI: 1.10, 4.25), after adjusting for sociodemographic variables. Major depression was also associated with a greater odds of ART medication non-adherence, 2.52 (95% CI: 1.20, 5.28), after adjusting for gender. Conclusion: As previously found in the general population, we found significant associations between depression and smoking and other non-injection drug use among HIV-positive adults. Major depression was also associated with a greater odds of ART medication non-adherence, which is also consistent with the literature. Because HIV-positive adults have ongoing encounters with healthcare providers, screening and treatment for depression and other co-morbid substance use is needed to reduce an additional health burden in this population.

In recent decades, a number of philosophers have sought to explain the nature of human action using Aristotle’s theory of material constitution. According to these neo-Aristotelian accounts, material objects serve as the paradigm cases for analysing the concept of action. As composites of matter and form, material objects—and, in particular, biological organisms—possess a kind of constitutive unity: they are “hylomorphic wholes”. The same kind of unity purportedly exists with regard to actions, which are constituted likewise. My task in this paper will be to give a precise articulation of this thesis and what it entails. If the neo-Aristotelian claim is right, then material objects really do serve as the paradigm cases for understanding the constitution of action. In Chapter III, I will simply presume the truth of this general claim, in order to focus my attention on the relative merits and weaknesses of specific arguments given in support of it. Before considering these arguments, however, we will need to first clarify Aristotle’s thesis concerning material objects. This will be my aim in Chapter II. In general, I will accept the conventional Aristotelian position that a material thing, qua concrete substance, is constituted by substantial form in matter, a unified whole. I will presume as correct the Thomistic conception of such composites, which employs the distinction between act and potency: matter is pure potentiality for the reception of form, and form is “a determinate actualisation of this potentiality”. / text

Eight cyclic analogues of Substance P were made in order to investigate the conformation of the C-terminal end of the peptide. These analogues were designed to test three literature models describing the active conformation of substance P. Although the potencies of the analogues were low (in the micromolar range), our results support Cotrait's and Hospital's model (1986). Several substance P antagonists were synthesized. These compounds did not demonstrate agonistic activity nor anatagonistic activity. The tryptophan side chain is contributing to the antagonistic activity of these analogues, and not just the chirality of the α-carbon. Highly potent and selective photoaffinity ligands of H-Tyr-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) and D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH₂ (CTP) were synthesized. These compounds will be useful in the isolation of δ and μ opioid receptors. Several new amino acids designed and synthesized to contain both the natural amino acid side chain and a thiol group which can be used to make disulfide constraints. The racemic amino acids made were as follows: (1) 2-amino-4-methyl-2- [(p-methylbenzyl)thiomethyl] pentanoic acid; (2) 2-amino-2- [(p-methylbenzyl)thiomethyl] -3-phenylpropanoic acid; (3) 2-amino-e- [(p-methylbenzyl)thio] pentanoic acid; and (4) 2-amino-3- [(p-methylbenzyl)-thio] -3-phenyl-pentanoic acid. These amino acids will be useful in the conformational restriction of peptides. To investigate the δ-opioid receptor conformation proposed for DPDPE by Hruby et al. (1988) and the μ-opioid receptor conformation proposed for Tyr-c [Abu₂,Gly,Phe,Leu] by Mierke et al. (1988), constrained phenylalanine amino acids were incorporated into H-Try-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) in the four position. Our results indicate that these models are correct. And in an investigation into the physical-chemical properties of the delta opioid receptor, our results suggest that the δ receptor topochemical site for the Phe⁴ residue contains a partial positive charge on its surface and has specific steric requirements.

Women have been the focus of a great deal of research on opiate addiction and treatment because their gender is assumed to matter for their experiences in the drug world. Much of this has focused on women's experiences as mothers and caregivers. While men are often included as subjects in research on opiate addiction and treatment, their experiences as gendered beings are rarely analyzed. This research foregrounds men's gendered experiences as fathers, family members, and partners while in methadone maintenance treatment. Using data from addiction history interviews with 33 opiate-dependent men recruited from a single methadone clinic in Arizona, I find that men assign considerable significance to their family relationships. The men interviewed report that their experiences as fathers, grandfathers, sons, grandsons, brothers, husbands, and boyfriends both motivate them to seek methadone treatment for opiate addiction, and cause stress that sometimes pushes them to use or relapse on opiates. Given the importance of these men's family relationships, I argue that the marginalized masculinity of impoverished, drug-dependent men includes an ethic of care. Additionally, I argue that counselors in methadone clinics should consider men in the context of their family relationships in order to provide better treatment to men struggling to recover from opiate addiction.

No description available.

The purpose of this study is to sample a number of disparate texts from the early Islamic cultural field to explore the shared grounds or themes that bind them together. The focus of the sampled texts and their analysis is the different relations between God and the real things of this world. The method that is applied in the selection of the texts of this research relies on Pierre Bourdieu’s approach to the study of cultural production. It assumes a relational and dynamic intellectual field which creates interlinked differences and similarities. This is the reason for sampling texts which are assumed to be reasonably marginal to the main cultural establishment. The kalām of the early stage, exemplified by the texts of the Zaydī al-Qāsim al-Rassī and the eastern Ibādīs, is found to emphasise the radical separation between the creator and the created. The development of this relation, which is explored through an intertextual reading of Qurʾānic exegesis, bridges the fissure, between creator and created, through the process of re-interpreting the terms of creation. The act of creation itself becomes an act of transformation, and the objects of creation become eternal ‘non-existent things’ that acquire the quality of existence. In the philosophical works of Jābir Ibn Ḥayyān, the things of this world are also reduced to transformations within the one substance that encompasses the intelligible and the material world. The results of this research show that there is a great degree of diffusion of ideas in this early stage of Islamic culture, from an assumed centre to the margins, and vice versa. The general tendencies in the texts considered reflect, on the one hand, a critique of multiplicity of principles, particularly dualism, and an emphasis on God’s unity, through different interpretations of tawḥīd. On the other hand, the sought unity itself established God’s radical transcendence from the real world, thus leading to another form of dualism dividing the world and the absolute other. The process of opposition to dualism seems to have eventually produced two forms of affirming and defining unity. Both forms define the existent things in terms of substance (jawhar), however, the kalām model expresses it in atomistic terms whilst the alchemical model of Jābir expresses it in terms of a hylomorphic model. One of these redefines the meanings of the existent and the non-existent things in term of subsistence, and the other, develops the idea of a single substance with different gradation in being.

Substance use behaviours have been viewed as the end products of a combination of influences. Numerous theories for working with substance use behaviour utilizing a multi-systemic approach have been proposed. In this project, an effort was made to control for limitations and problems that have often beset previous studies utilizing such an approach. The overall objective of the current project was to test, using a multi-systemic approach, the ability of the family socialization framework to explain the development of substance use patterns in youth and young adults. The central hypothesis of this project was that family socialization factors (contextual factors) affect and predict the development of an offspring’s personality (individual factors) and substance use behaviour. The behavioural genetic approach (i.e., the adoption design) was utilized to examine the genetic and environmental impacts on associations between factors. This project used secondary data analyses of general population data to examine the links between aspects of the family environment, personality, and substance use patterns. The Vancouver Family Survey data set used here contained information on fathers, mothers, and offspring from 405 families (328 biological and 77 adoptive) at two points in time. The development of personality and substance use behaviours over time, and associations with family socialization factors, were examined through three studies. Study 1 focused on the associations between offspring’s perspectives of fathers’ and mothers’ parental socialization and offspring’s polysubstance use. Study 2 investigated the development of addiction-prone personality characteristics and the predictive effects of family socialization and demographic variables on these characteristics. Study 3 explored the subscales of the Addiction-Prone Personality scale: impulsivity/recklessness, sensation seeking, negative view of self, and social deviance proneness. The descriptive characteristics of each subscale and changes in subscale scores over time were investigated. Also examined were transgenerational associations on these subscales, and potential relationships between personality subscales and choice of substance. The results of this project suggest that family socialization may be linked with both substance use behaviour and personality development over time. Nurturing family socialization is negatively associated with the development of addiction-prone personality characteristics. It is also negatively associated with the development of substance use behaviours. These results are consistent with previous studies utilizing a family socialization framework. The findings supporting the family socialization framework are very encouraging for the field of child, youth, and family-related practice. Some of the limitations of the current project, implications of the findings, and future research directions are discussed. / Graduate

It is imperative to acknowledge the crisis state of African American adolescents as they transit into young adulthood. Professional literature has documented the usage of cigarettes, alcohol, marijuana and other drugs during the transitional period. Chemical substance misusage among some adolescents resulting in critical incidents continues to gain increased interest for the counseling profession and others. Special emphasis is placed on drug prevention education program in schools. A selected group of adolescents were administered the PRIDE survey instrument for this research study. The instrument was designed to assess the student's history, pattern, attitude, prevalence and critical incidents involving cigarettes, alcohol, marijuana and other drug misusage. Descriptive research techniques were utilized for this study. Ninety-one respondents were randomly selected among the population of two hundred students. The research findings were overwhelming. Based on the findings, there is no significant difference in drug usage among adolescents in rural and metropolitan areas in the United States.

Introduction: African American adolescents have a higher prevalence of risky sexual behavior compared to Hispanic and White adolescents. African American adolescents account for 65% of HIV diagnoses among individuals aged 13 to 24 years (Jackson et al., 2015). The rising rate of new STI and HIV cases remains a public health concern and the need for intervention in target populations is outstanding. The objective of this study is to measure the association between alcohol and other substance use and risky sexual behaviors in African American adolescents in the United States. Methods: Data from the Centers for Disease Control and Prevention’s (CDC) 2015 National Youth Risk Behavior Surveillance Survey (YRBS) was used in this study. SAS 9.3 software package was used for descriptive analysis, univariate logistic regression, and multivariate logistic regression of assessing the relationship between alcohol and drug use with risky sexual behaviors in black adolescents in comparison with white adolescents. Results: When controlling for age, gender, and all other variables, African American adolescents that reported ever consuming alcohol were 2.2 (OR=2.2 95% CI=1.6-3.2 p= <.0001) times more likely to ever had sex, 3.8 (OR=3.8 95% CI= 2.9-4.9 p= <.0001) times more likely to have had sex with 4 or more people in the past 3 months, and 1.3 (OR=1.3 95% CI=0.8-2.1 p= <.0001) times more likely to have had sexual intercourse with at least 4 people in their lifetime. When asked if they ever used marijuana, adolescents that reported at least once were 4.5 (OR=4.5 95% CI= 3.2-6.5 p=<.0001) likely to have engaged in sexual intercourse, 3.8 (OR=3.8 95% CI=2.6-5.5 p= <.0001) times more likely to have had sex with four or more people in the past 3 months, and 6.1 (OR=6.1 95% CI=3.7-10.2 p= <.0001) times more likely to have at least 4 sexual partners in their lifetime. Conclusions: The findings of this study indicate that use of illicit substances does increase risky sexual behaviors in African American Adolescents. Further implications of this study can be utilized in the development of intervention programs. Intervention programs should target African American adolescents that engage in risky sexual behaviors and any substance use.

Managing anthropogenic emissions in urban areas is a major challenge in sustainable environmental development for cities, and future changes and increasing urbanisation may increase this challenge. Systems perspectives have become increasingly important in helping urban managers understand how different changes may alter future emissions and whether current management strategies can efficiently manage these emissions. This thesis provides some systems perspectives that have been lacking in previous studies on modelling and managing future anthropogenic emissions in urban areas. The city of Stockholm, Sweden, was selected as the study site and studies about nitrogen, phosphorus and carbon were chosen, given world-wide urban eutrophication and global concerns about climate change. A substance flow analysis (SFA) structured model, comprising a source model coupled with a watershed model in an SFA structure, was developed to investigate future nutrient loading scenarios under various urban changes in small urban lake catchments. The results demonstrated that climate change potentially posed a greater threat to future nutrient loads to a selected lake catchment in Stockholm than the other scenarios examined. Another SFA-based study on future phosphorus flows through the city of Stockholm indicated that the best management option may depend on the perspective applied when comparing future scenarios of phosphorus flows and that both upstream and downstream measures need to be considered in managing urban phosphorus flows. An evaluation approach for examining current management plans and low-carbon city initiatives using the Driving forces-Pressure-States-Impact-Response (DPSIR) framework, was formulated. With such an evaluation approach, investigation of how well selected plans cover different aspects of the DPSIR framework and whether root causes and systematic measures are highlighted is possible. The results revealed that the current low-carbon city initiative in Stockholm falls within pressure-based, driver-orientated plans and that technical, institutional and cognitional measures are generally well covered. / <p>QC 20160510</p>