The current study explored the effects of simulated adjustment domains (i.e., partial denial and social desirability) on specialized substance abuse measures in a sample of 104 inpatient offenders with substance use disorders. Results indicated nearly two thirds (57.9%) of offenders successfully escaped detection on the SASSI-4 and InDUC-2R. Further, subtle approaches employed by the SASSI-4 failed to detect unacknowledged substance use by simulators, and the remaining decision rules were redundant and most likely contributed to the false positive rates for non SU offenders. More promisingly, the current study developed an empirically based validity scale to bolster the SASSI-4's effectiveness in detecting response styles that showed initial promise. Results, a review of detection strategies for SU validity scales, and implications for assessment are further explored.