Over the past years early detection and intervention in schizophrenia have become a major objective in psychiatry. Early intervention strategies are intended to identify and treat psychosis prior to fulfilling diagnostic criteria for the disorder. To this aim, reliable early diagnostic biomarkers are needed in order to identify a high-risk state for psychosis and also predict transition to frank psychosis in those high-risk individuals destined to develop the disorder. Recently, machine learning methods have been successfully applied in the diagnostic classification of schizophrenia and in predicting transition to psychosis at an individual level based on magnetic resonance imaging (MRI) data and also neurocognitive variables. This work investigates the application of machine learning methods for the early identification of schizophrenia in subjects at high risk for developing the disorder. The dataset used in this work involves data from the Edinburgh High Risk Study (EHRS), which examined individuals at a heightened risk for developing schizophrenia for familial reasons, and the FePsy (Fruherkennung von Psychosen) study that was conducted in Basel and involves subjects at a clinical high-risk state for psychosis. The overriding aim of this thesis was to use machine learning, and specifically Support Vector Machine (SVM), in order to identify predictors of transition to psychosis in high-risk individuals, using baseline structural MRI data. There are three aims pertaining to this main one. (i) Firstly, our aim was to examine the feasibility of distinguishing at baseline those individuals who later developed schizophrenia from those who did not, yet had psychotic symptoms using SVM and baseline data from the EHRS study. (ii) Secondly, we intended to examine if our classification approach could generalize to clinical high-risk cohorts, using neuroanatomical data from the FePsy study. (iii) In a more exploratory context, we have also examined the diagnostic performance of our classifier by pooling the two datasets together. With regards to the first aim, our findings suggest that the early prediction of schizophrenia is feasible using a MRI-based linear SVM classifier operating at the single-subject level. Additionally, we have shown that the combination of baseline neuroanatomical data with measures of neurocognitive functioning and schizotypal cognition can improve predictive performance. The application of our pattern classification approach to baseline structural MRI data from the FePsy study highly replicated our previous findings. Our classification method identified spatially distributed networks that discriminate at baseline between subjects that later developed schizophrenia and other related psychoses and those that did not. Finally, a preliminary classification analysis using pooled datasets from the EHRS and the FePsy study supports the existence of a neuroanatomical pattern that differentiates between groups of high-risk subjects that develop psychosis against those who do not across research sites and despite any between-sites differences. Taken together, our findings suggest that machine learning is capable of distinguishing between cohorts of high risk subjects that later convert to psychosis and those that do not based on patterns of structural abnormalities that are present before disease onset. Our findings have some clinical implications in that machine learning-based approaches could advise or complement clinical decision-making in early intervention strategies in schizophrenia and related psychoses. Future work will be, however, required to tackle issues of reproducibility of early diagnostic biomarkers across research sites, where different assessment criteria and imaging equipment and protocols are used. In addition, future projects may also examine the diagnostic and prognostic value of multimodal neuroimaging data, possibly combined with other clinical, neurocognitive, genetic information.

Made available in DSpace on 2016-08-29T15:33:12Z (GMT). No. of bitstreams: 1 tese_3521_.pdf: 2782962 bytes, checksum: d4b2294e5ee9ab86b7a35aec083af692 (MD5) Previous issue date: 2010-02-12 / Os Modelos de Predição implementados pelos algoritmos de Aprendizagem de Máquina advindos como linha de pesquisa da Inteligência Computacional são resultantes de pesquisas e investigações empíricas em dados do mundo real. Neste contexto; estes modelos são extraídos para comparação de duas grandes técnicas de aprendizagem de máquina Redes Neuro-Fuzzy e de Regressão aplicadas no intuito de estimar um parâmetro de qualidade do produto em um ambiente industrial sob processo contínuo. Heuristicamente; esses Modelos de Predição são aplicados e comparados em um mesmo ambiente de simulação com intuito de mensurar os níveis de adequação dos mesmos, o poder de desempenho e generalização dos dados empíricos que compõem este cenário (ambiente industrial de mineração).

Bioinformatics techniques to protein secondary structure prediction mostly depend on the information available in amino acid sequence. Support vector machines (SVM) have shown strong generalization ability in a number of application areas, including protein structure prediction. In this study, a new sliding window scheme is introduced with multiple windows to form the protein data for training and testing SVM. Orthogonal encoding scheme coupled with BLOSUM62 matrix is used to make the prediction. First the prediction of binary classifiers using multiple windows is compared with single window scheme, the results shows single window not to be good in all cases. Two new classifiers are introduced for effective tertiary classification. This new classifiers use neural networks and genetic algorithms to optimize the accuracy of the tertiary classifier. The accuracy level of the new architectures are determined and compared with other studies. The tertiary architecture is better than most available techniques.

In this thesis, we present a vehicle detection and tracking system based on image processing and pattern recognition of single camera image sequences. Both software design and hardware implementation are considered. In the hypothesis generation (HG) step and the hypothesis verification (HV) step, we use the shadow detection technique combined with the proposed constrained vehicle width/distance ratio to eliminate unreasonable hypotheses. Furthermore, we use SVM classifier, a popular machine learning technique, to verify the generated hypothesis more precisely. In the vehicle tracking step, we limit vehicle tracking duration and periodic vehicle detection mechanisms. These tracking methods alleviate our driver-assistant system from executing complex operations of vehicle detection repeatedly and thus increase system performance without sacrificing too much in case of tracking wrong objects. Based on the the profiling of the software execution time, we implement by hardware the most critical part, the preprocessing of intensity conversion and edge detection. The complete software/hardware embedded system is realized in a FPGA prototype board, so that performance of whole system could achieve real-time processing without too much hardware cost.

Capsule Endoscopy (CE) is a unique technique for facilitating non-invasive and practical visualization of the entire small intestine. It has attracted a critical mass of studies for improvements. Among numerous studies being performed in capsule endoscopy, tremendous efforts are being made in the development of software algorithms to identify clinically important frames in CE videos. This thesis presents a computer-assisted method which performs automated detection of CE video-frames that contain bleeding. Specifically, a methodology is proposed to classify the frames of CE videos into bleeding and non-bleeding frames. It is a Support Vector Machine (SVM) based supervised method which classifies the frames on the basis of color features derived from image-regions. Image-regions are characterized on the basis of statistical features. With 15 available candidate features, an exhaustive feature-selection is followed to obtain the best feature subset. The best feature-subset is the combination of features that has the highest bleeding discrimination ability as determined by the three performance-metrics: accuracy, sensitivity and specificity. Also, a ground truth label annotation method is proposed in order to partially automate delineation of bleeding regions for training of the classifier. The method produced promising results with sensitivity and specificity values up to 94%. All the experiments were performed separately for RGB and HSV color spaces. Experimental results show the combination of the mean planes in red and green planes to be the best feature-subset in RGB (Red-Green-Blue) color space and the combination of the mean values of all three planes of the color space to be the best feature-subset in HSV (Hue-Saturation-Value).

Capsule Endoscopy (CE) is a unique technique for facilitating non-invasive and practical visualization of the entire small intestine. It has attracted a critical mass of studies for improvements. Among numerous studies being performed in capsule endoscopy, tremendous efforts are being made in the development of software algorithms to identify clinically important frames in CE videos. This thesis presents a computer-assisted method which performs automated detection of CE video-frames that contain bleeding. Specifically, a methodology is proposed to classify the frames of CE videos into bleeding and non-bleeding frames. It is a Support Vector Machine (SVM) based supervised method which classifies the frames on the basis of color features derived from image-regions. Image-regions are characterized on the basis of statistical features. With 15 available candidate features, an exhaustive feature-selection is followed to obtain the best feature subset. The best feature-subset is the combination of features that has the highest bleeding discrimination ability as determined by the three performance-metrics: accuracy, sensitivity and specificity. Also, a ground truth label annotation method is proposed in order to partially automate delineation of bleeding regions for training of the classifier. The method produced promising results with sensitivity and specificity values up to 94%. All the experiments were performed separately for RGB and HSV color spaces. Experimental results show the combination of the mean planes in red and green planes to be the best feature-subset in RGB (Red-Green-Blue) color space and the combination of the mean values of all three planes of the color space to be the best feature-subset in HSV (Hue-Saturation-Value).

Among the elderly, falling represents a major threat to the individual health, and is considered as a major source of morbidity and mortality. In Sweden alone, three elderly are lost each day in accidents related to falling. The elderly who survive the fall are likely to be suffering from decreased quality of life. As the percentage of elderly increase in the population worldwide, the need for preventive methods and tools will grow drastically in order to deal with the increasing health-care costs. This report is the result of a conceptual study where an algorithm for individualized motion monitoring and pre-impact fall detection is developed. The algorithm learns the normal state of the wearer in order to detect anomalous events such as a fall. Furthermore, this report presents the requirements and issues related to the implementation of such a system. The result of the study is presented as a comparison between the individualized system and a more generalized fall detection system. The conclusion is that the presented type of algorithm is capable of learning the user behaviour and is able to detect a fall before the user impacts the ground, with a mean lead time of 301ms. / Bland äldre är risken för att drabbas av fallrelaterade skador överhängande, ofta med svåra fysiska skador och psykiska effekter som följd. Med en ökande andel äldre i befolkningsmängden beräknas även samhällets kostnad för vård att stiga. Genom aktiva samt preventiva åtgärder kan graden av personligt lidande och fallre- laterade samhällskostnader reduceras. Denna rapport är resultatet av en konceptuell studie där en algoritm för aktiv, individanpassad falldetektion utvecklats. Algoritmen lär sig användarens normala rörelsemönster och skall därefter särskilja dessa från onormala rörelsemönster. Rapporten beskriver de krav och frågeställningar som är relevanta för utvecklingen av ett sådant system. Vidare presenteras resultatet av studien i form av en jämförelse mellan ett individanpassat och generellt system. Resultatet av studien visar att algoritmen kan lära sig användarens vanliga rörelsemönster och därefer särskilja dessa från ett fall, i medelvärde 301ms innan användaren träffar marken.

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This thesis focuses on bare hand gesture recognition by proposing a new architecture to solve the problem of real-time vision-based hand detection, tracking, and gesture recognition for interaction with an application via hand gestures. The first stage of our system allows detecting and tracking a bare hand in a cluttered background using face subtraction, skin detection and contour comparison. The second stage allows recognizing hand gestures using bag-of-features and multi-class Support Vector Machine (SVM) algorithms. Finally, a grammar has been developed to generate gesture commands for application control. Our hand gesture recognition system consists of two steps: offline training and online testing. In the training stage, after extracting the keypoints for every training image using the Scale Invariance Feature Transform (SIFT), a vector quantization technique will map keypoints from every training image into a unified dimensional histogram vector (bag-of-words) after K-means clustering. This histogram is treated as an input vector for a multi-class SVM to build the classifier. In the testing stage, for every frame captured from a webcam, the hand is detected using my algorithm. Then, the keypoints are extracted for every small image that contains the detected hand posture and fed into the cluster model to map them into a bag-of-words vector, which is fed into the multi-class SVM classifier to recognize the hand gesture. Another hand gesture recognition system was proposed using Principle Components Analysis (PCA). The most eigenvectors and weights of training images are determined. In the testing stage, the hand posture is detected for every frame using my algorithm. Then, the small image that contains the detected hand is projected onto the most eigenvectors of training images to form its test weights. Finally, the minimum Euclidean distance is determined among the test weights and the training weights of each training image to recognize the hand gesture. Two application of gesture-based interaction with a 3D gaming virtual environment were implemented. The exertion videogame makes use of a stationary bicycle as one of the main inputs for game playing. The user can control and direct left-right movement and shooting actions in the game by a set of hand gesture commands, while in the second game, the user can control and direct a helicopter over the city by a set of hand gesture commands.

The development of technologies for preventing drowsiness at the wheel is a major challenge in the field of accident avoidance systems. Preventing drowsiness during driving requires a method for accurately detecting a decline in driver alertness and a method for alerting and refreshing the driver. As a detection method, the authors have developed a system that uses image processing technology to analyse images of the road lane with a video camera integrated with steering wheel angle data collection from a car simulation system. The main contribution of this study is a novel algorithm for drowsiness detection and tracking, which is based on the incorporation of information from a road vision system and vehicle performance parameters. Refinement of the algorithm is more precisely detected the level of drowsiness by the implementation of a support vector machine classification for robust and accurate drowsiness warning system. The Support Vector Machine (SVM) classification technique diminished drowsiness level by using non intrusive systems, using standard equipment sensors, aim to reduce these road accidents caused by drowsiness drivers. This detection system provides a non-contact technique for judging various levels of driver alertness and facilitates early detection of a decline in alertness during driving. The presented results are based on a selection of drowsiness database, which covers almost 60 hours of driving data collection measurements. All the parameters extracted from vehicle parameter data are collected in a driving simulator. With all the features from a real vehicle, a SVM drowsiness detection model is constructed. After several improvements, the classification results showed a very good indication of drowsiness by using those systems.