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Single Particle Studies on the Influence of the Environment on the Plasmonic Properties of Single and Assembled Gold Nanoparticles of Various ShapesSwanglap, Pattanawit 16 September 2013 (has links)
Plasmonic nanoparticles and their assembly have the potential to serve as a platform in practical applications such as photonics, sensing, and nano-medicine. To use plasmonic nanoparticles in these applications, it is important to understand their optical properties and find methods to control their optical response. Using polarization-sensitive dark-field spectroscopy to study self-assembled nanoparticle rings on substrates with different permittivities I show that the interaction between collective plasmon resonances and the substrate can control the spatial scattering image. Using liquid crystals as an active medium that can be controlled with an external electric field I show that the Fano resonance of an asymmetric plasmonic assembly can be actively controlled utilizing the polarization change of scattered light passing through the liquid crystal device. Furthermore, utilizing the strong electromagnetic field enhancement of coupled plasmonic “nanospikes” on the surface of gold nanoshells with a silica core, I show the use of single spiky nanoshells as surface-enhanced Raman spectroscopy substrates. Individual spiky nanoshells give surprisingly reproducible surface-enhanced Raman spectroscopy intensities with a low standard deviation compared to clusters of nanoparticles. In summary, the work presented here provides understanding of the plasmonic response for assembled nanoparticles on different substrates, illustrated a new method to actively control the optical response of plasmonic nanoparticles, and characterizes spiky nanoshells as surface-enhanced Raman scattering platform.
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Control of Surface Plasmon Substrates and Analysis of Near field StructureChen, Shiuan-Yeh January 2011 (has links)
<p>The electromagnetic properties of various plasmonic nanostructures are investigated. These nanostructures, which include random clusters, controlled clusters and particle-film hybrids are applied to surface-enhanced Raman scattering (SERS). A variety of techniques are utilized to fabricate, characterize, and model these SERS-active structures, including nanoparticle functionalization, thin film deposition, extinction spectroscopy, elastic scattering spectroscopy, Raman scattering spectroscopy, single-assembly scattering spectroscopy, transmission electron microscopy, generalized Mie theory, and finite element method. </p><p>Initially, the generalized Mie theory is applied to calculate the near-field of the small random clusters to explain their SERS signal distribution. The nonlinear trend of SERS intensity versus size of clusters is demonstrated in experiments and near-field simulations. </p><p>Subsequently, controlled nanoparticle clusters are fabricated for quantitative SERS. A 50 nm gold nanoparticle and 20nm gold nanoparticles are tethered to form several hot spots between them. The SERS signal from this assembly is compared with SERS signals from single particles and the relative intensities are found to be consistent with intensity ratios predicted by near-field calculation.</p><p>Finally, the nanoparticle/film hybrid structure is studied. The scattering properties and SERS activity are observed from gold nanoparticles on different substrates. The gold nanoparticle on gold film demonstrates high field enhancement. Raman blinking is observed and implies a single molecule signal. Furthermore, the doughnut shape of Raman images indicates that this hybrid structure serves as nano-antenna and modifies the direction of molecular emission. </p><p>In additional to the primary gap dipole utilized for SERS, high order modes supported by the nanoparticle/film hybrid also are investigated. In experiments, the HO mode show less symmetry compared to the gap dipole mode. The simulation indicates that the HO modes observed may be comprised of two gap modes. One is quadrupole-like and the other is dipole-like in terms of near-field profile. The analytical treatment of the coupled dipole is performed to mimic the imaging of the quadrupole radiation.</p> / Dissertation
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Study of SERS effect by controlling the arrangement of colloidsLin, Zhe-Hong 15 August 2011 (has links)
In this research, two major experiments, including the self-assembly of silica spheres, were performed by using a physical confinement method with an attractive capillary force. The silica spheres were dragged and aggregated as results of the evaporation of the solvent.
In the first experiment, silica spheres were assembled into the two-dimensional pattered substrate, constructed by the photo-resist film formed under a lithography process. Several patterned substrates could work as a physical trap during the flow of the silica spheres. The ordered arrangement of the silica spheres was controlled by the concentration and the size of the silica spheres, the thickness of the photo-resist film, and the titled angle of the substrate. In our conditions, the silica spheres could orderly arrange in larger area of the substrate.
In the second experiment, a surface-enhanced Raman scattering (SERS) enhancement was observed from a chain of silica spheres with silver nanoparticles, which worked as a excitation source to provid a strong local electromagnetic fields exciting the crystal violet (CV) dye coated on the silica spheres. We found that the CV molecules has a strong SERS intensity due to the refraction and reflection of the incident light within the silica spheres. When the silica spheres were linearly arranged, longer length of the chained silica spheres would lead to a maximum value of the SERS intensity.
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Nanofluidic biosensing for beta-amyloid detectionChou, I-Hsien 15 May 2009 (has links)
A nanofluidic biosensor using surface-enhanced Raman scattering (SERS) was
developed to detect the β-amyloid (Aβ) protein, one of the biomarkers of Alzheimer’s
disease (AD). Recent studies have indicated that investigating changes in relative
concentrations of structure specific Aβ oligomers in cerebral spinal fluid (CSF) during the
progression of AD could be important indicators for diagnosing AD pre-mortem. However,
there is no definitive pre-mortem diagnosis of AD thus far because of the lack of technology
available for sensitive Aβ detection. Hence, the development of a system for detecting the
structure specific Aβ oligomers, along with the concentrations of these oligomers in CSF,
would be useful in the investigation of the molecular mechanisms of Aβ cytotoxicity
associated with AD.
In this thesis, a nanofluidic trapping device trapping system for detecting
biomolecules at sub-picomolar concentrations was developed for using SERS. The device,
with a microchannel leading to a nanochannel, carries out dual functions: encouraging sizedependent
trapping of gold nanoparticles (60nm) at the entrance of the nanochannel as well as restricting the target molecules between the gaps created by the aggregated nanoparticles.
Initially, the trapping capability of the nanofluidic device was tested using fluorescent
polystyrene and gold nanoparticles. UV-vis absorption spectroscopy was used to characterize
the gold nanoparticle clusters at the entrance to the nanochannel. The device established
controlled, reproducible, SERS active sites within the interstices of gold nanoparticle clusters
and shifted the plasmon resonance to the near infrared, in resonance with incident laser light.
Two strongly Raman active molecules, adenine and Congo red, were used to test the
feasibility of the SERS nanofluidic device as a platform for the detection of multiple
analytes. The results showed that strong SERS signals were obtained from the nanoparticle
clusters at the nanochannel entrance.
Once the feasibility of the approach was determined with strong Raman molecules,
Aβ was detected using this nanofluidic SERS platform. Distinct surface-enhanced Raman
spectra of Aβ was observed in different conformational states as a function of concentration
and structure (monomer versus oligomer form) due to Aβ refolding from α-helical to a
predominantly β-pleated sheet form. The sensor was also shown to potentially distinguish Aβ
from insulin and albumin, confounder proteins in cerebral spinal fluid. Thus, a novel
platform was developed to detect picomoler levels of Aβ with the ultimate goal of facilitating
the diagnosis and understanding of Alzheimer’s disease by means of detecting structure
specific oligomers of Aβ.
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Optical Properties of Plasmonic Zone Plate Lens, SERS-active Substrate and Infrared Dipole AntennaKim, Hyun Chul 2009 August 1900 (has links)
Nowadays plasmonics is rapidly developing areas from fundamental studies to
more application driven research. This dissertation contains three different research
topics on plasmonics. In the first research topic, by modulating the zone width of a
plasmonic zone plate, we demonstrate that a beam focused by a proposed plasmonic
zone plate lens can be achieved with higher intensity and smaller spot size than the
diffraction-limited conventional zone plate lens. This sub-diffraction focusing capability
is attributed to extraordinary optical transmission, which is explained by the complex
propagation constant in the zone regions afforded by higher refractive index dielectric
layer and surface plasmons. On the other hand, the resulted diffraction efficiency of this
device is relatively low. By introducing a metal/dielectric multilayered zone plate, we
present higher field enhancement at the focal point. This higher field enhancement
originates not only from surface plasmon polaritons-assisted diffraction process along
the propagation direction of the incident light (longitude mode), but also from multiple
scattering and coupling of surface plasmons along the metal/dielectric interface
(transverse mode). In the second research topic, we suggest a novel concept of SERS-active
substrate applications. The surface-enhanced Raman scattering enhancement factor
supported by gap surface plasmon polaritons is introduced. Due to higher effective
refractive index induced by gap surface plasmon polaritons in the spacer region between
two metal plates, incident light tends to localize itself mostly in the medium with higher
refractive index than its adjacent ones and thereby the lights can confine with larger field
enhancement.
In the last research topic, we offer a simple structure in which a gold dipole
antenna is formed on the SiC substrate. Surface phonon polaritons, counterparts of
surface plasmon polaritons in the mid-infrared frequencies, are developed. Due to the
synergistic action between the conventional dipole antenna coupling and the resonant
excitation of surface phonon polaritons, strong field enhancement in the gap region of
dipole antenna is attained.
Most of research topics above are expected to find promising applications such
as maskless nanolithography, high resolution scanning optical microscopy, optical data
storage, optical antenna, SERS-active substrate, bio-molecular sensing and highly
sensitive photo-detectors.
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Design and Fabrication of Nanochannel DevicesWang, Miao 2009 August 1900 (has links)
Nanochannel devices have been explored over the years with wide applications in bio/chemical analysis. With a dimension comparable to many bio-samples, such as proteins, viruses and DNA, nanochannels can be used as a platform to manipulate and detect such analytes with unique advantages. As a prerequisite to the development of nanochannel devices, various nanofabrication techniques have been investigated by many researchers for decades. In this dissertation, three different fabrication approaches for nanochannels are discussed, including a novel scanning coaxial electrospinning process, a heat-induced stretching approach and a standard contact photolithography process. The scanning coaxial electrospinning process is established based on conventional electrospinning process. A coaxial jet, with the motor oil as the core and spin-on-glass-coating/PVP solution as the shell, is deposited on the rotating collector as oriented coaxial nanofibers. These nanofibers are then annealed to eliminate the core material and form the hollow interior. Silica nanochannels with an inner diameter as small as 15 nm were obtained. The heat-induced stretching approach includes using commercially available fused silica tubings to create nanochannels by thermal deforming. This method and the electrospinning technique both focus on fabricate one-dimensional nanochannels with a circular opening. Fluorescent dye was used as a testing sample for single molecule detection and electrokinetic analysis in the resultant nanochannels. Another nanochannel device described in this dissertation has a deep-shallow step structure. It was fabricated by standard contact lithography, followed by etching and bonding. This device was applied as a powerful detection platform for surface-enhanced Raman spectroscopy (SERS). The experiment results proved that it is able to highly improve the sensitivity and efficiency of SERS. The SERS enhancement factor obtained from the device is 108. Moreover, the molecule enrichment effect of this device provides an extra 105 enhancement. The detection can be efficiently finished within minutes after simply loading the mixture of analytes solution and gold nanoparticles in the device. The sample consumption is in micro-liter range. Potential applications in diagnostics, prognositics and water pollutants detection could be achieved using this device.
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Organic/inorganic hybrid nanostructures for chemical plasmonic sensorsChang, Sehoon 30 March 2011 (has links)
The work presented in this dissertation suggests novel design of chemical plasmonic sensors which have been developed based on Localized Surface Plasmon Resonance (LSPR), and Surface-enhanced Raman scattering (SERS) phenomena. The goal of the study is to understand the SERS phenomena for 3D hybrid (organic/inorganic) templates and to design of the templates for trace-level detection of selected chemical analytes relevant to liquid explosives and hazardous chemicals. The key design criteria for the development of the SERS templates are utilizing selective polymeric nanocoatings within cylindrical nanopores for promoting selective adsorption of chemical analyte molecules, maximizing specific surface area, and optimizing concentration of hot spots with efficient light interaction inside nanochannels. The organic/inorganic hybrid templates are optimized through a comprehensive understanding of the LSPR properties of the gold nanoparticles, gold nanorods, interaction of light with highly porous alumina template, and the choice of physical and chemical attributes of the selective coating.
Furthermore, novel method to assemble silver nanoparticles in 3D as the active SERS-active substrate has been demonstrated by uniform, in situ growth of silver nanoparticles from electroless deposited silver seeds excluding any adhesive polymer layer on template. This approach can be the optimal for SERS sensing applications because it is not necessary to separate the Raman bands of the polyelectrolyte binding layer from those of the desired analyte. The fabrication method is an efficient, simple and fast way to assemble nanoparticles into 3D nanostructures.
Addressable Raman markers from silver nanowire crossbars with silver nanoparticles are also introduced and studied. Assembly of silver nanowire crossbar structure is achieved by simple, double-step capillary transfer lithography. The on/off SERS properties can be observed on silver nanowire crossbars with silver nanoparticles depending on the exact location and orientation of decorated silver nanoparticles nearby silver nanowire crossbars.
As an alternative approach for the template-assisted nanostructure design, porous alumina membrane (PAM) can be utilized as a sacrificial template for the fabrication of the nanotube structure. The study seeks to investigate the design aspects of polymeric/inorganic hybrid nanotube structures with plasmonic properties, which can be dynamically tuned by external stimuli such as pH.
This research suggests several different organic/inorganic nanostructure assemblies by various template-assisted techniques. The polymeric/inorganic hybrid nanostructures including SERS property, pH responsive characteristics, and large surface area will enable us to understand and design the novel chemical plasmonic sensors.
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Surface enhanced Raman spectroscopy of olivine type battery cathode LiFePO4Delone, Nicholas Ryan 17 December 2010 (has links)
This thesis explores the use of Raman Spectroscopy to study the battery cathode material LiFePO4. Surface Enhanced Raman Spectroscopy (SERS) was incorporated into the study due to fluorescence that traditionally plagues Raman. By imaging LiFePO4 nanoparticles, an understanding can be gained of the complex chemistry taking place when the material is lithiated and delithiated at the nanoscale level and the phase changes of the material that occur during this process. The use of bimetallic (Au/Ag) SERS substrates allowed for more stable substrates with longer shelf life compared single metal Ag substrates. Further tuning of these substrates can be applied to the ever evolving science of energy storage material technology as a way to track phase changes in the material. / text
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Design of Raman Active Phopsholipid Gold Nanoparticles for Plasmonics based Tumour Detection and ImagingTam, Natalie Chin Mun 20 December 2011 (has links)
Cancer is the leading cause of death worldwide and one third of its burden can be decreased with early detection. Surface enhanced Raman spectroscopic (SERS) based imaging is a promising new technique for non-invasive detection of tumours due to its ultra-sensitivity and multiplexing capabilities. For in vivo SERS molecular imaging, a biocompatible, robust and targeted nanoparticle is required to attain high sensitivity and specificity. In this thesis, a SERS capable gold nanoparticle was rationally designed by encapsulation with a phospholipid bilayer which conferred biocompatibility, colloidal stability and versatility to changing surface chemistry. Moreover, validation of this SERS probe with a specific targeting ligand for carcinoma cells was studied through the targeting of a commonly overexpressed cancer receptor, epidermal growth factor receptor. Using this phospholipid design, optimizations with differing chemistries, targeting ligand or modifications for additional functionalities can be achieved for further development as a viable in vivo molecular imaging tool.
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Design of Raman Active Phopsholipid Gold Nanoparticles for Plasmonics based Tumour Detection and ImagingTam, Natalie Chin Mun 20 December 2011 (has links)
Cancer is the leading cause of death worldwide and one third of its burden can be decreased with early detection. Surface enhanced Raman spectroscopic (SERS) based imaging is a promising new technique for non-invasive detection of tumours due to its ultra-sensitivity and multiplexing capabilities. For in vivo SERS molecular imaging, a biocompatible, robust and targeted nanoparticle is required to attain high sensitivity and specificity. In this thesis, a SERS capable gold nanoparticle was rationally designed by encapsulation with a phospholipid bilayer which conferred biocompatibility, colloidal stability and versatility to changing surface chemistry. Moreover, validation of this SERS probe with a specific targeting ligand for carcinoma cells was studied through the targeting of a commonly overexpressed cancer receptor, epidermal growth factor receptor. Using this phospholipid design, optimizations with differing chemistries, targeting ligand or modifications for additional functionalities can be achieved for further development as a viable in vivo molecular imaging tool.
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