This dissertation presents innovative research on Shape Memory Alloy (SMA)-actuated active steerable needles to address the limitations of conventional bevel tip needles in needle-based medical procedures such as biopsy, brachytherapy, tissue ablation and drug delivery. The active needle design proposed in this study surpasses the limitations of conventional needles by enabling large tip deflection and active control of deflection during needle insertion, thereby achieving accurate needle placement. A needle prototype was developed, demonstrating substantial 50mm and 39mm tip deflections at a 150mm insertion depth in liver and prostate-mimicking gels, respectively. Finite Element Analysis (FEA) accurately predicted the tip deflection in tissue-mimicking gels, with simulation errors measuring only 16.42% and 12.62% in the liver-mimicking gel and prostate-mimicking gel, respectively, validating the effectiveness of the FEA framework developed in this research for predicting tip deflection in soft tissues. Furthermore, a real-time trajectory tracking control system using a Proportional Integral (PI) controller was designed for the SMA-actuated needle, which resulted in minor root mean square errors (RMSE) of 1.42mm and 1.47mm in the two gels, respectively, highlighting the applicability of the needle design. The capabilities of the active needle, including improved tip deflection and trajectory tracking control, enable it to bypass obstacles, maneuver around critical anatomical structures, and increase the accuracy of needle placement, thus enhancing patient safety and procedure success rates.A bioinspired approach was introduced to enhance the functionality of SMA-actuated needles, drawing inspiration from the mosquito proboscis's unique design and skin-piercing technique. By incorporating an innovative cannula design and applying axial vibration to the SMA-actuated needle, a significant reduction in needle-tissue interaction friction was achieved, which resulted in increased needle tip deflection and improved steering accuracy. Including these bioinspired features led to a remarkable decrease in insertion force by up to 26.24% and an increase in tip deflection by 37.11%. Furthermore, the trajectory tracking error was reduced by 48%, and the control effort decreased by 23.25%, underscoring the benefits of the bioinspired enhancements in improving needle insertion mechanics and control. The findings presented in this dissertation illustrate the potential of SMA-actuated needles and bioinspired features in enhancing needle steering performance during minimally invasive needle-based procedures. Future research will focus on further refining the needle design and control systems, expanding experimental tests to biological tissues, and exploring the application of these advancements on a clinically applicable scale. / Mechanical Engineering