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1	SIMULTANEOUS SURGICAL RESECTIONS OF TWO DISTANT METASTATIC MALIGNANT MELANOMA LESIONS : CASE REPORT WAKABAYASHI, TOSHIHIKO, HIRANO, MASAKI, TAKEBAYASHI, SHIGENORI, NAKAHARA, NORIMOTO, TANEI, TAKAFUMI 02 1900 (has links) No description available. Metastatic Surgical resection Simultaneous Multiple Malignant melanoma
2	Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation Weidinger, Gilbert, Schnabel, Kristin, Wu, Chi-Chung, Kurth, Thomas 07 January 2016 (has links) (PDF) In mammals, myocardial cell death due to infarction results in scar formation and little regenerative response. In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, whether zebrafish can also regenerate lesions caused by cell death has not been tested. Here, we present a simple method for induction of necrotic lesions in the adult zebrafish heart based on cryoinjury. Despite widespread tissue death and loss of cardiomyocytes caused by these lesions, zebrafish display a robust regenerative response, which results in substantial clearing of the necrotic tissue and little scar formation. The cellular mechanisms underlying regeneration appear to be similar to those activated in response to ventricular resection. In particular, the epicardium activates a developmental gene program, proliferates and covers the lesion. Concomitantly, mature uninjured cardiomyocytes become proliferative and invade the lesion. Our injury model will be a useful tool to study the molecular mechanisms of natural heart regeneration in response to necrotic cell death. Herz Zebrafisch TU Dresden Publikationsfonds Heart Heart regeneration Zebrafish Surgical resection Myocardium Cardiac ventricles Epicardium Regeneration Technical University Dresden Publication funds ddc:610 rvk:XA 10000
3	Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation Weidinger, Gilbert, Schnabel, Kristin, Wu, Chi-Chung, Kurth, Thomas 07 January 2016 (has links) In mammals, myocardial cell death due to infarction results in scar formation and little regenerative response. In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, whether zebrafish can also regenerate lesions caused by cell death has not been tested. Here, we present a simple method for induction of necrotic lesions in the adult zebrafish heart based on cryoinjury. Despite widespread tissue death and loss of cardiomyocytes caused by these lesions, zebrafish display a robust regenerative response, which results in substantial clearing of the necrotic tissue and little scar formation. The cellular mechanisms underlying regeneration appear to be similar to those activated in response to ventricular resection. In particular, the epicardium activates a developmental gene program, proliferates and covers the lesion. Concomitantly, mature uninjured cardiomyocytes become proliferative and invade the lesion. Our injury model will be a useful tool to study the molecular mechanisms of natural heart regeneration in response to necrotic cell death. info:eu-repo/classification/ddc/610 ddc:610
4	Pooperační projevy po resekci vestibulárního schwannomu a jejich dopad na kvalitu života / Postoperative symptoms after vestibular schwannoma surgery and their impact on quality of life Koutná, Sára January 2019 (has links) Vestibular schwannoma is one of the most common tumors found in a cerebellopontine angle. Despite tumor's benignity, there are many cases that are indicated for a surgical resection. Frequently postoperative symptoms described by patients and also by literature are hearing loss, vertigo, tinnitus and weakness or numbness of face. Our work wants to show also other factors which can be damaging for patient life. We talk about postoperative headache and anxiety or depression disorders. The aim of the study will be describe these symptoms, try to find the corelations between them and determine the impact on quality of life. In our survey, patients one year after vestibular schwannoma resection recieve convenient questionnaires to fill. The questionnaires will be focused on headache disability, anxiety and depression, vestibular dysfunction and perception of quality of life.

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