With the globalization era, software companies around the world not only have to face competition in the domestic industry, as well as the subsequent challenge of large international companies. For this reason, domestic software companies must to upgrade their own software quality. Domestic government agencies and non-governmental units together promote Capability Maturity Model Integration (CMMI). Hope to improve their quality of software development process through internationalized professional evaluation. Towards the high-maturity software development process, software development process should be estimated quantitatively in CMMI Level 4. There are frequently used statistical process control (SPC) methods, including control charts, fishbone diagram, pareto charts ... and other related practices. Its goal is to maintain stability of overall software development process, so the output performance can be expected. Primitive SPC applied in manufacturing industry, successfully improving the quality of their products. But some characteristics of software, such as software development is human-intensive and innovative activities. It increases not only variability of control, but also difficulties of implementation. In this study, collate and analyze the operational framework of SPC and CMMI Level 4 through study of literature and case study with the case company-A company's practices. It contains two points, one is organization point of view, the other is methodological point of view. Organizational point of view includes stage of CMMI Level 4 and SPC implemented in the software industry, as well as how to design the organizational structure. Methodological point of view includes the steps to run SPC¡Buseful methods and tools. Methodological point of view also uses control theory to collate relevant control mechanisms. Finally, we illustrate how to integrate SPC into the company's system development life cycle. The framework can provide a reference for domestic software companies of longing for implementing CMMI Level 4 and SPC.