Magister Scientiae - MSc (Pharmacy Administration and Policy Regulation) / Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory- frameworks in place over the period from 1995 to 2015. The study was structured in two distinct phases: the first involved document review of available legislation and secondary data relevant to the subject matter, covering the study period; the second involved a questionnaire survey for health practitioners to gather opinions on the effectiveness of the medicines regulatory systems in Zambia. Assessment of secondary data reported by Ministry of Health, and World Health Organisation on treatment outcomes and medicines regulation was conducted. Reviewed data showed relative reduction in incidence of some selected diseases of national importance. It was also evident that the regulatory systems had improved considerably over the study period. Responses from Health Practitioners and other players in the health and pharmaceutical sectors indicated that they were aware of medicines regulatory requirements, supported the need for medicines regulation, and indicated the need for regional collaboration and increased public awareness raising as means for improving current medicines regulatory systems. It was recommended that more comprehensive studies be undertaken to establish causal relationships between medicines regulatory systems, and disease outcomes. A further recommendation was made to implement more integrated information management systems in the Ministry of Health, and the Zambia Medicines Regulatory Authority.

Objective: With the overall goal to harmonize prospective effectiveness assessment of active safety systems, the specific objective of this study is to identify and evaluate sources of variation in virtual precrash simulations and to suggest topics for harmonization resulting in increased comparability and thus trustworthiness of virtual simulation-based prospective effectiveness assessment. Methods: A round-robin assessment of the effectiveness of advanced driver assistance systems was performed using an array of state-of-the-art virtual simulation tools on a set of standard test cases. The results were analyzed to examine reasons for deviations in order to identify and assess aspects that need to be harmonized and standardized. Deviations between results calculated by independent engineering teams using their own tools should be minimized if the research question is precisely formulated regarding input data, models, and postprocessing steps. Results: Two groups of sources of variations were identified; one group (mostly related to the implementation of the system under test) can be eliminated by using a more accurately formulated research question, whereas the other group highlights further harmonization needs because it addresses specific differences in simulation tool setups. Time-to-collision calculations, vehicle dynamics, especially braking behavior, and hit-point position specification were found to be the main sources of variation. Conclusions: The study identified variations that can arise from the use of different simulation setups in assessment of the effectiveness of active safety systems. The research presented is a first of its kind and provides significant input to the overall goal of harmonization by identifying specific items for standardization. Future activities aim at further specification of methods for prospective assessments of the effectiveness of active safety, which will enhance comparability and trustworthiness in this kind of studies and thus contribute to increased traffic safety.

A number of approaches of assessment associated with IS effectiveness have been examined, fundamental guidelines for research in this area have been derived, and a novel model of IS effectiveness has been proposed. A process based assessment method (PB-ISAM) based on the proposed effectiveness model has been elaborated. The new model and the new assessment method have been evaluated via three case studies. Specific implications have been drawn concerning the relationships between processes and the information system assessed. The three case studies have provided insight into the IS effectiveness field and for future work.

International Telemetering Conference Proceedings / October 26-29, 1992 / Town and Country Hotel and Convention Center, San Diego, California / MIL-STD-1553 multiplex data buses are commonly used to link complex software-controlled systems in modern aircraft. The software in these aircraft is routinely updated; each update requires flight testing. Also, sophisticated weapons and electronic warfare systems which are integrated into operationally-ready aircraft must be routinely evaluated. The simplest way to perform the required evaluation is to record all the data from the multiplex data buses during an operational flight; these data can then be replayed and examined after the flight. Traditionally, some operational systems had to be disabled or removed from an aircraft to allow installation of a data acquisition system. This paper discusses a MILSTD- 1553 multiplex bus Record-All Small Data Acquisition System (RASDAS) installed in a McDonnell Douglas CF-188 fighter aircraft to record all data from two 1553 multiplex data buses without displacing any operational equipment. The specific requirements and constraints associated with evaluating the integrated systems of a CF-188 aircraft are examined; further, RASDAS implementation in this aircraft type is discussed from planning to flight evaluation.

Diploma thesis is focused on the assessment of the information system and the proposal for ICT modification of specific company. The first part of thesis concerns with systematic formulation of the theoretical background which is necessary for the explanation of important concepts from the field of information systems. The practical part deals with the analysis of the company as a whole and especially with the analysis of IS. In the last part of thesis are proposed options how to achieve an improvement of the current state of business information system and information technology in the selected company based on the analysis and identification of problems of the current state of the information system.