La tomodensitométrie (TDM) permet d'obtenir, et ce de façon non invasive, une image tridimensionnelle de l'anatomie interne d'un sujet. Elle constitue l'évolution logique de la radiographie et permet l'observation d'un volume sous différents plans (sagittal, coronal, axial ou n'importe quel autre plan). La TDM peut avantageusement compléter la tomographie d'émission par positrons (TEP), un outil de prédilection utilisé en recherche biomédicale et pour le diagnostic du cancer. La TEP fournit une information fonctionnelle, physiologique et métabolique, permettant la localisation et la quantification de radiotraceurs à l'intérieur du corps humain. Cette dernière possède une sensibilité inégalée, mais peut néanmoins souffrir d'une faible résolution spatiale et d'un manque de repère anatomique selon le radiotraceur utilisé. La combinaison, ou fusion, des images TEP et TDM permet d'obtenir cette localisation anatomique de la distribution du radiotraceur. L'image TDM représente une carte de l'atténuation subie par les rayons-X lors de leur passage à travers les tissus. Elle permet donc aussi d'améliorer la quantification de l'image TEP en offrant la possibilité de corriger pour l'atténuation. L'image TDM s'obtient par la transformation de profils d'atténuation en une image cartésienne pouvant être interprétée par l'humain. Si la qualité de cette image est fortement influencée par les performances de l'appareil, elle dépend aussi grandement de la capacité de l'algorithme de reconstruction à obtenir une représentation fidèle du milieu imagé. Les techniques de reconstruction standards, basées sur la rétroprojection filtrée (FBP, filtered back-projection), reposent sur un modèle mathématiquement parfait de la géométrie d'acquisition. Une alternative à cette méthode étalon est appelée reconstruction statistique, ou itérative. Elle permet d'obtenir de meilleurs résultats en présence de bruit ou d'une quantité limitée d'information et peut virtuellement s'adapter à toutes formes de géométrie d'acquisition. Le présent mémoire se consacre à l'étude de ces algorithmes statistiques en imagerie TDM et à leur implantation logicielle. Le prototype d'imageur TEP/TDM basé sur la technologie LabPET[indice supérieur TM] de l'Université de Sherbrooke possède tous les pré-requis pour bénéficier de ces nombreux avantages.

A demanda de largura de banda exigida pelos usuários de redes de acesso vem aumentando rapidamente e a rede óptica passiva baseada em multiplexação por divisão de comprimento de onda (WDM-PON) tem se destacado como a tecnologia capaz de suprir essa demanda. Dessa forma, este trabalho conduz, inicialmente, uma comparação entre uma rede WDM-PON ideal e uma rede TDM-PON, discutindo também aspectos de segurança desta última, bem como estratégias de migração entre estes dois esquemas. Devido ao custo elevado da WDM-PON em seu esquema original, investigou-se em seguida as principais arquiteturas alternativas relatadas na literatura, em busca de maior viabilidade de implementação. Com base nesse estudo, fez-se então uma análise mais profunda sobre topologias recentes derivadas da RITENET, referenciadas na literatura como arquiteturas baseadas em fontes ópticas centralizadas (CLS). Tais configurações são baseadas no travamento de diodos lasers Fabry-Pérot através da injeção do sinal de ASE de um EDFA e foram estudadas por meio de simulações computacionais empregando o software OptiSystem 8.0. / The demand for bandwidth by access networks users has increased rapidly and the Wavelength Division Multiplexing - Passive Optical Network (WDM-PON) has been pointed out as the technology capable of meeting this demand. In this framework, this work initially carries out a comparison between an ideal WDM-PON network and a TDM-PON network, also discussing TDM-PON security issues as well as migration strategies from TDM-PON to WDM-PON configurations. Next, taking into account the high implementation cost of the WDM-PON original scheme, we investigated alternative topologies available in the literature. Based on this study, we performed a more in-depth analysis regarding recently proposed topologies, derived from the RITENET, which are refered at the literature as centralized light sources (CLS) based architectures. Such networks are based on the locking of Fabry-Pérot lasers diodes through the injection of the ASE signal from an EDFA and were studied by using the software OptiSystem 8.0.

Optical fibers have brought fast and reliable data transmission to todays network. The immense fiber build-out over the last few years has generated a wide array of new access technologies, transport and network protocols, and next-generation services in the Local Area Network (LAN), Metropolitan Area Network (MAN), and Wide Area Network (WAN). All these different technologies, protocols, and services were introduced to address particular telecommunication needs. To remain competitive in the market, the service providers must offer most of these services, while maintaining their own profitability. However, offering a large variety of equipment, protocols, and services posses a big challenge for service carriers because it requires a huge investment in different technology platforms, lots of training of staff, and the management of all these networks.<p> In todays network, service providers use SONET (Synchronous Optical NETwork) as a basic TDM (Time Division Multiplexing) transport network. SONET was primarily designed to carry voice traffic from telephone networks. However, with the explosion of traffic in the Internet, the same SONET based TDM network is optimized to support increasing demand for packet based Internet network services (data, voice, video, teleconference etc.) at access networks and LANs. Therefore the service providers need to support their Internet Protocol (IP) infrastructure as well as in the legacy telephony infrastructure. Supporting both TDM and packet services in the present condition needs multilayer operations which is complex, expensive, and difficult to manage. A hybrid switch is a novel architecture that combines packets (IP) and TDM switching in a unified access platform and provides seamless integration of access networks and LANs with MAN/WAN networks. The ability to fully integrate these two capabilities in a single chassis will allow service providers to deploy a more cost effective and flexible architecture that can support a variety of different services.<p> This thesis develops a hybrid switch which is capable of offering bundled services for TDM switching and packet routing. This is done by dividing the switchs bandwidth into VT1.5 (Virtual Tributary -1.5) channels and providing SONET based signaling for routing the data and controlling the switchs resources. The switch is a TDM based architecture which allows each switchs port to be independently configured for any mixture of packet and TDM traffic, including 100% packet and 100% TDM. This switch allows service providers to simplify their edge networks by consolidating the number of separate boxes needed to provide fast and reliable access. This switch also reduces the number of network management systems needed, and decreases the resources needed to install, provision and maintain the network because of its ability to collapse two network layers into one platform.<p> The scope of this thesis includes system architecture, logic implementation, and verification testing, and performance evaluation of the hybrid switch. The architecture consists of ingress/egress ports, an arbiter and a crossbar. Data from ingress ports is carried to the egress ports via VT1.5 channels which are switched at the cross point of the crossbar. The crossbar setup and channel assignments at ingress port are done by the arbiter. The design was tested by simulation and the hardware cost was estimated. The performance results showed that the switch is non-blocking, provide differentiated service, and has an overall effective throughput of 80%. This result is a significant step towards the goal of building a switch that can support multiprotocol and provide different network capabilities into one platform. The long-term goal of this project is to develop a prototype of the hybrid switch with broadband capability.

Optical fibers have brought fast and reliable data transmission to todays network. The immense fiber build-out over the last few years has generated a wide array of new access technologies, transport and network protocols, and next-generation services in the Local Area Network (LAN), Metropolitan Area Network (MAN), and Wide Area Network (WAN). All these different technologies, protocols, and services were introduced to address particular telecommunication needs. To remain competitive in the market, the service providers must offer most of these services, while maintaining their own profitability. However, offering a large variety of equipment, protocols, and services posses a big challenge for service carriers because it requires a huge investment in different technology platforms, lots of training of staff, and the management of all these networks.<p> In todays network, service providers use SONET (Synchronous Optical NETwork) as a basic TDM (Time Division Multiplexing) transport network. SONET was primarily designed to carry voice traffic from telephone networks. However, with the explosion of traffic in the Internet, the same SONET based TDM network is optimized to support increasing demand for packet based Internet network services (data, voice, video, teleconference etc.) at access networks and LANs. Therefore the service providers need to support their Internet Protocol (IP) infrastructure as well as in the legacy telephony infrastructure. Supporting both TDM and packet services in the present condition needs multilayer operations which is complex, expensive, and difficult to manage. A hybrid switch is a novel architecture that combines packets (IP) and TDM switching in a unified access platform and provides seamless integration of access networks and LANs with MAN/WAN networks. The ability to fully integrate these two capabilities in a single chassis will allow service providers to deploy a more cost effective and flexible architecture that can support a variety of different services.<p> This thesis develops a hybrid switch which is capable of offering bundled services for TDM switching and packet routing. This is done by dividing the switchs bandwidth into VT1.5 (Virtual Tributary -1.5) channels and providing SONET based signaling for routing the data and controlling the switchs resources. The switch is a TDM based architecture which allows each switchs port to be independently configured for any mixture of packet and TDM traffic, including 100% packet and 100% TDM. This switch allows service providers to simplify their edge networks by consolidating the number of separate boxes needed to provide fast and reliable access. This switch also reduces the number of network management systems needed, and decreases the resources needed to install, provision and maintain the network because of its ability to collapse two network layers into one platform.<p> The scope of this thesis includes system architecture, logic implementation, and verification testing, and performance evaluation of the hybrid switch. The architecture consists of ingress/egress ports, an arbiter and a crossbar. Data from ingress ports is carried to the egress ports via VT1.5 channels which are switched at the cross point of the crossbar. The crossbar setup and channel assignments at ingress port are done by the arbiter. The design was tested by simulation and the hardware cost was estimated. The performance results showed that the switch is non-blocking, provide differentiated service, and has an overall effective throughput of 80%. This result is a significant step towards the goal of building a switch that can support multiprotocol and provide different network capabilities into one platform. The long-term goal of this project is to develop a prototype of the hybrid switch with broadband capability.

A demanda de largura de banda exigida pelos usuários de redes de acesso vem aumentando rapidamente e a rede óptica passiva baseada em multiplexação por divisão de comprimento de onda (WDM-PON) tem se destacado como a tecnologia capaz de suprir essa demanda. Dessa forma, este trabalho conduz, inicialmente, uma comparação entre uma rede WDM-PON ideal e uma rede TDM-PON, discutindo também aspectos de segurança desta última, bem como estratégias de migração entre estes dois esquemas. Devido ao custo elevado da WDM-PON em seu esquema original, investigou-se em seguida as principais arquiteturas alternativas relatadas na literatura, em busca de maior viabilidade de implementação. Com base nesse estudo, fez-se então uma análise mais profunda sobre topologias recentes derivadas da RITENET, referenciadas na literatura como arquiteturas baseadas em fontes ópticas centralizadas (CLS). Tais configurações são baseadas no travamento de diodos lasers Fabry-Pérot através da injeção do sinal de ASE de um EDFA e foram estudadas por meio de simulações computacionais empregando o software OptiSystem 8.0. / The demand for bandwidth by access networks users has increased rapidly and the Wavelength Division Multiplexing - Passive Optical Network (WDM-PON) has been pointed out as the technology capable of meeting this demand. In this framework, this work initially carries out a comparison between an ideal WDM-PON network and a TDM-PON network, also discussing TDM-PON security issues as well as migration strategies from TDM-PON to WDM-PON configurations. Next, taking into account the high implementation cost of the WDM-PON original scheme, we investigated alternative topologies available in the literature. Based on this study, we performed a more in-depth analysis regarding recently proposed topologies, derived from the RITENET, which are refered at the literature as centralized light sources (CLS) based architectures. Such networks are based on the locking of Fabry-Pérot lasers diodes through the injection of the ASE signal from an EDFA and were studied by using the software OptiSystem 8.0.

International Telemetering Conference Proceedings / October 27-30, 1997 / Riviera Hotel and Convention Center, Las Vegas, Nevada / The Low Earth Orbit Terminal (LEO-T) developed by AlliedSignal for NASA Wallops is a fully autonomous satellite tracking system which provides a reliable, high quality, satellite data collection and dissemination service. The procurement was initiated by NASA, in an effort to provide more tracking capacity with a decreasing budget. A large mission set of NASA satellites in the next decade will not require the performance of existing large aperture systems. NASA is planning to use the larger aperture antennas to only support those missions needing the higher performance. The remainder of the missions will be supported with the smaller LEO-Ts, which are smaller, significantly less expensive, and fully automated. The procurement is also an attempt at a first step towards fostering commercialization and privatization of small station acquisition and services. The system design features a modular architecture to simplify integration and to support affordable future expansion. This paper begins with a brief summary of the LEO-T program, then provides the design details and capabilities of the LEO-T system.

L'objectif général du travail de cette thèse est de proposer des méthodes robustes pour permettre d’obtenir des critères sur l’évolution de la pathologie tumorale à partir d’études dynamiques. Actuellement, l’appréciation de l’efficacité d’un traitement antiangiogénique (destruction des vaisseaux alimentant la tumeur) repose principalement sur l’imagerie fonctionnelle dont l’objectif est de quantifier la microcirculation tumorale à partir d’acquisitions dynamiques de perfusion. Cependant, différentes limites concernant le suivi de la réponse précoce des lésions par imagerie existent (mauvaise maîtrise des mouvements respiratoires, pas de consensus sur les paramètres permettant de quantifier la microcirculation tumorale, estimation paramétrique faite à partir de données extrêmement bruitées et pour un grand nombre de zones - une estimation par voxel de la séquence dynamique d’images). Dans un contexte clinique extrêmement contraignant, nous avons mis en place un cadre rigoureux comprenant l’ensemble des étapes nécessaires pour une caractérisation plus fiable de la microcirculation tumorale à partir de séquences d’images acquises sous perfusion de produit de contraste : les contributions principales de cette thèse couvrent ainsi l’optimisation des paramètres de reconstruction, le développement d’une méthode de recalage adaptée à nos données, la sélection argumentée d’un modèle de perfusion et enfin le développement d’une méthode robuste d’estimation des paramètres. Ces travaux permettent d’envisager l’utilisation des modèles de perfusion pour la caractérisation et la prédiction de la réponse d’un patient à différents traitements antitumoraux. / The main objective is to propose robust methods to allow estimation of functional markers reflecting the tumor evolution from dynamic studies. Currently, in this domain, assessing of the efficiency evaluation of an anti-angiogenic therapy (destruction of vessels which feed the tumor) is mainly based on the functional imaging of the microcirculation, which the objective is to quantify the tumor microcirculation by dynamic acquisitions with injection of contrast product. However, several limitations are present (lack of control of the breathing movement, no consensus on the parameters permitting the quantification of tumor microcirculation, parameter estimation computed from noisy data and a large number of regions - one estimation by voxel or group of voxel of the dynamic image sequence). In a restrictive clinical context (noisy data, few number), we have developed a complete pipeline with a set of necessary steps to a reliable characterization of the tumor microcirculation from dynamic perfusion image sequence: the main contributions of this thesis cover the reconstruction parameters optimization, the development of a registration method, the argued selection of a perfusion model and the development of a robust method of parameter estimation. With these works, we can envision the utilization of these perfusion models to the characterization and the prediction of the therapy response of a patient

När olika datatyper överförs mellan två platser har, historiskt sett, detta skett på skildinfrastruktur; analoga signaler för sig, och digitala data för sig. Inom flygindustrin hanteras båda dessa datatyper än idag, då övergång från analoga röstsamtal till digitala röstsamtal tar tid. För att förenkla infrastrukturen är det önskvärt att skicka all data på samma medium. Time Division Multiplexing (TDM) möjliggör detta och har studerats med fokus på robusthet och prestanda. Studien har fokuserat på hur TDM-enheter ska konfigureras med avseende på Ethernet-frame-storlek för att till fullo utnyttja länkkapaciteten. Teoretiska resonemang har validerats av experimentella data som utförts på TDM-enheter sammankopplade med en fiberlänk. Antalet förlorade frames för systemet har mätts med varierande datatillförselshastighet. Detta upprepades för ett flertal Ethernet-frame-storlekar. Mindre frame-storlekar gav en högre möjlig överföringshastighet innan data förloras, och uppvisade koherens mellan teori och experiment. Stora frame-storlekar fyllde i snitt TDM-tidsluckorna sämre, och gjorde att databuffert på enheten fylldes snabbare än för mindre framstorlekar. Detta ledde till dataförluster i systemet. Andra faktorer, som overhead och payload, gjorde att framestorleken borde väljas efter applikation. Mindre datamängder som skickas ofta kan med fördel använda mindre frame-storlekar, medan stora datamängder som behöveröverföras snabbt effektivare överförs med större frame-storlekar. / When transferring different data types between two sites, they have historically been transferred on separate infrastructures; analog signals separately, and digital data separately. Within the aviation industry, both these data types are still handled today, as transition from analog voice data to digital voice data takes time. To simplify the infrastructure, it is desirable to send all data on the same medium. Time Division Multiplexing (TDM) makes this possible and has been studied with focus on robustness and performance. The study has focused on how TDM devices should be configured with respect to Ethernet frame size to fully utilize link capacity. Theoretical reasoning has been validated by experimental data performed on TDM devices coupled with a fiber link. The number of lost frames for the system has been measured while varying data rates. This was repeated for several Ethernet frame sizes. Smaller frame sizes showed a higher possible transfer rate before data loss was recorded. This shows coherence between theory and experiments. Larger frame sizes were less good at filling the TDM time slots, causing data buffer on the device to overflow faster than for smaller frame sizes. This created data loss in the system. Other factors, such as overhead and payload, implies that the frame size should be chosen by application. Smaller data volumes that are sent frequently have an advantage when using smaller frame sizes, while when handling largeramounts of data that need to be transmitted quickly, it is more efficient to use larger frame sizes

This thesis provides the reader with an overview of the many elements that are involved in geosynchronous satellite point-to-multipoint Internet Protocol (IP)-based multimedia communications design and also takes a deep dive into the analysis of a real-life scenario, using the TDM / MF-SCPC and TDM / MF-TDMA media access techniques. This thesis starts with a discussion of satellite network topologies utilized within point-to-multipoint satellite communications followed by an overview of the satellite communications channel. A discussion on the intelligent and proper selection of modulation and coding follows. Descriptions and characteristics of the satellite access technologies chosen to be analyzed are next followed by a detailed description of Forward Error Correction (FEC) techniques and a discussion on network-wide tradeoffs so selecting different options. The thesis then presents the results of a real-life scenario, investigating both TDM / MF-SCPC and TDM / MF-TDMA media access technique options, pointing out the tradeoffs brought to the forefront earlier in the study. The major takeaway is that there does not exist a one-size-fits-all solution that works for each and every scenario. / Master of Science

Although vehicle miles traveled (VMT) has become the standard for assessing transportation related impacts in California, some have concerns that many VMT estimates are not properly grounded or informed by real world data, potentially resulting in flawed estimates and impact assessments. This is especially true of special generators, like college and university campuses, which have complex travel patterns distinct from that of the general public. This thesis attempts to resolve a significant disparity observed between two credible VMT estimates for Cal Poly’s campus wide VMT. As part of a campus master planning effort, a VMT estimate was produced in 2019 for an environmental impact report (EIR), using a travel demand model (TDM) based approach. This result was quite divergent from a prior 2018 estimate which used contemporaneous survey data (a data source often used to ground and calibrate/validate TDM results), leaving an approximate difference of 200 million VMT to be accounted for. In an attempt to address this disparity, this investigation considered three distinct analyses, including a quantitative assessment of variability of the 2018 travel survey estimate (via a bootstrap), an accounting of missing VMT not captured by the 2018 estimate, and a final comparison of the reliability and credibility of the 2018 and 2019 estimates based on both qualitative (scope and methodological issue of the estimates) and quantitative (benchmarking reported metrics) factors. Based on this investigation’s findings, although the disparity can be partially explained, a significant deficit of over 100 million VMT remained, suggesting the 2019 estimate may have overstated campus VMT and its impacts. It also suggests that campuses have significant VMT generating functions beyond the frequently studied commuter and residential travel behaviors. The lessons learned from this thesis provide a roadmap to improving future VMT estimates for college and university campuses as well as how regulators may approach setting appropriate analysis requirements and impact thresholds for these unique land uses.