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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Rat brain cytosolic tyrosine transaminase: purification, characterization and identification as glutamine transaminase-K

Bowsher, Ronald R. January 1985 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
12

The Characterization of a Novel Putative Signalling Protein and its Interaction with Tyrosine 1253 of the NEU/ERBB2 Receptor Tyrosine Kinase / The Characterization of the p34-NEU/ERBB2 Interaction

Maslikowski, Bart 06 1900 (has links)
The Neu/ErbB2 receptor tyrosine kinase has been implicated in the induction of mammary tumourigenesis. Both Ras-dependent and independent signalling downstream of activated Neu is believed to mediate cellular signalling that contributes cellular transformation in oncogenic Neu. Signalling from five 𝘣𝘰𝘯𝘢 𝘧𝘪𝘥𝘦 autophosphorylation sites (termed sites A through E) in the carboxyl tail of the receptor mediate these signals to the cytosol. Of the four positive regulatory sites (B, C, D, E), only three (B, C, D,) signal through known signalling molecules. Site E, (Y1253) in Neu, though known to interact with DOKR is essentially an orphan site. The discovery of a 34kD protein capable of associating to peptides corresponding to site E prompted investigations into the nature of site E signalling. Mass spectrometric analyses revealed that the 34kD protein is 2,4-dienoyl-CoA reductase (DECR1), a lipid metabolism protein typically localized to the mitochondria. Investigations into this protein reveal that DECR1 is capable of associating with Neu site E in a tyrosine phosphorylation and sequence specific manner. Furthermore, analyses with site E second-site mutants (YE[APEY], YE[DPEY], YE[NAEY] and YE[NDEY]) show that DECR1 associates in a manner consistent to a PTB domain-containing protein. Analyses of amino acid sequence demonstrate the presence of a putative Bcl-domain in DECR1 suggestive of a role in apoptosis. Experiments into the apoptotic activity of DECR1 proved inconclusive. The examination of sub-cellular localization of Neu and DECR1 showed that the two proteins are found in both the mitochondrial and plasma membrane fractions. These results demonstrate that DECR1 may be a veritable binding partner for Neu Y1253. / Thesis / Master of Science (MSc)
13

Neuropeptide receptors and cell signals as targets in the development of novel therapies for small cell lung cancer

Seckl, Michael Julian January 1995 (has links)
No description available.
14

Fibroblast growth factor receptor signalling

Burgar, Helen Rachel January 2002 (has links)
No description available.
15

Tyrosine metabolism in the chicken

Wei, Alice Jun. January 1951 (has links)
Call number: LD2668 .T4 1951 W45 / Master of Science
16

Structural and functional studies of the Csk and Src family protein tyrosine kinases /

Ayrapetov, Marina K. January 2006 (has links)
Thesis (Ph. D.)--University of Rhode Island, 2006. / Typescript. Includes bibliographical references (leaves 136-153).
17

RET receptor tyrosine kinase in developing, adult and polycystic kidneys

Lee, Chun-wai, Davy. January 2000 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 148-170).
18

Experimental study and computer modeling of hydration-related behavior of L-tyrosine-derived polyarylates

Valenzuela, Loreto M. January 2009 (has links)
Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Biomedical Engineering." Includes bibliographical references (p. 139-158).
19

The effect of tyrosine kinase activators and inhibitors on the Q-T interval of an electrocardiogram /

Donaldson, Cynthia D. K., January 2004 (has links)
Thesis (M.S.)--Central Connecticut State University, 2004. / Thesis advisor: Cheryl Watson. " ... in partial fulfillment of the requirements for the degree of Master of Science in Biology." Includes bibliographical references (leaves 43-47). Also available via the World Wide Web.
20

Redox active tyrosine residues in biomimetic beta hairpins

Sibert, Robin S. January 2009 (has links)
Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2010. / Committee Chair: Bridgette Barry; Committee Member: David Collard; Committee Member: Ingeborg Schmidt-Krey; Committee Member: Jake Soper; Committee Member: Mira Josowicz. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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