Global ETD Search

11	Mechanisms of transcriptional regulation gene repression by KRAB zinc finger proteins and gene induction by estrogen receptor beta / Sripathy, Smitha P. January 2008 (has links) Thesis (Ph. D.)--Case Western Reserve University, 2008. / [School of Medicine] Department of Pharmacology. Includes bibliographical references. Estrogen Receptor beta. Tamoxifen.
12	Einfluss des Antiöstrogens Tamoxifen auf das Milchdrüsenwachstum der weiblichen Ratte Götze, Stephan, January 1981 (has links) Thesis (doctoral)--Freie Universität Berlin, 1981. Ratte Milchdrüse Wachstum Tamoxifen
13	Cholangiocarcinoma combination therapy Tamoxifen and Gemcitabine produce an additive effect in vitro due to differing mechanisms and will be an effective combination in vivo / Turk, Amy Nicole. January 2010 (has links) (PDF) Thesis (M.S.)--University of Alabama at Birmingham, 2010. / Title from PDF title page (viewed on June 25, 2010). Includes bibliographical references (p. 31-37).
14	Nolvadex- und Androcur-Behandlung bei metastasierenden Mammakarzinomen Kremer, Sybille, January 1987 (has links) Thesis (doctoral)--Köln, 1987. Brustkrebs. Cyproteronacetat. Tamoxifen.
15	Economics of breast cancer preventive strategies in a Medicaid program Borker, Rohit D. January 1900 (has links) Thesis (Ph. D.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains x, 158 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 133-145).
16	Studies of microsomal metabolism of tamoxifen, toremifene and droloxifene by liquid chromatography-mass spectrometry Yuan, Zhi-Xin January 1999 (has links) No description available. 615.1 Liver tumours; Tamoxifen therapy
17	Pharmacological manipulation of in vivo melanoma cell invasion Dewhurst, Lisa Odette January 1997 (has links) No description available. 615.1 Tamoxifen; Anti-invasive agents
18	Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase Cole, Laura Kathleen Unknown Date No description available. Phosphatidylcholine Sp1 Tamoxifen Cardiac Dysfunction
19	Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase Cole, Laura Kathleen 06 1900 (has links) Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT endogenously. Analysis of the proximal PEMT promoter in 3T3-L1 adipocytes revealed an important regulatory region. Sp1 binds to a GC-rich site within this section of the promoter and inhibits PEMT transcriptional activity. Tamoxifen is an anti-estrogen drug widely used for the treatment of hormone-responsive breast cancer but has a frequent side-effect of increasing accumulation of lipid in the liver (hepatic steatosis). Tamoxifen represses PEMT gene expression by promoting Sp1 binding to the promoter. However, decreased catalytic activity of PEMT was not a major initial contributor to tamoxifen-mediated hepatic steatosis. We found that increased de novo fatty acid synthesis is the primary event which leads to tamoxifen-induced steatosis in mouse liver. Tamoxifen did not significantly alter hepatic fatty acid uptake, triacylglycerol secretion or fatty acid oxidation. Finally, we provide evidence that deletion of the PEMT gene in a well-established mouse model of atherosclerosis (apolipoprotein E deficient) reduces the formation of aortic lesions and prevents the associated development of dilated cardiomyopathy. This beneficial effect is likely due a reduction of atherogenic lipoproteins. These results indicate that treatment strategies aimed at the inhibition of PEMT could prevent the development of atherosclerosis that predisposes individuals to heart failure. Phosphatidylcholine Sp1 Tamoxifen Cardiac Dysfunction
20	The influence of flutamide, tamoxifen and dietary fat on hormone-induced mammary carcinogenesis Leung Wai, Ching-wa, Gina. January 2002 (has links) Thesis (Ph.D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 201-254) Also available in print.

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