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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Níveis de proteínas de fase aguda em equinos expostos à sobrecarga de carboidratos associada à alcalinização cecal /

Rabelo, Isabela Peixoto January 2019 (has links)
Orientador: Carlos Augusto Araújo Valadão / Resumo: Avanços acerca da fisiopatologia da laminite equina permitiram imputar como fator primário e deflagrador dos estágios iniciais dessa doença, a ativação da cascata inflamatória. Sabe-se que equinos submetidos à sobrecarga de carboidratos, podem desenvolver laminite e que essa afecção se dá por mudanças na microbiota do trato gastrintestinal. A laminite induz alterações sistêmicas que repercutem nos valores de proteínas de fase aguda (PFA). Com este estudo, buscou-se encontrar uma associação entre os valores dessas proteínas com a evolução dos sinais clínicos de equinos expostos à sobrecarga de carboidrato (amido de milho na dose de 17,6 g/kg de peso vivo, diluído em água na proporção de um quilo/litro, fornecido via sondagem nasogástrica) e tratados com solução tampão intracecal (composto contendo 3,5 g de hidróxido de alumínio, 65,6 g de hidróxido de magnésio e 1,2 g de simeticona, diluído em água destilada em volume equivalente à metade do volume administrado via sondagem nasogástrica). Dez equinos hígidos foram divididos de maneira aleatória e fatorial (2x2), em quatro grupos (n=5): controle (GCC), controle + tratamento (GCT), laminite (GAC), laminite + tratamento (GAT). Os animais do GCC e GAC integraram, respectivamente, GAT e GCT, respeitando um intervalo de 15 dias entre o procedimento experimental. Eles foram avaliados durante sete momentos (T0h, T4h, T8h, T12h, T24h, T48h, T72h), nos quais também foram coletadas amostras de sangue venoso para obtenção do soro e realiz... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: It’s is known that the inflammatory response plays an important role in the development of the equine laminitis, mostly in its early stages. Among several risk factors, horses submitted to carbohydrate overload can develop this syndrome, due to changes in the cecal pH and microbiota, followed by an increase in the transmural absorption of several luminal contents, such as bacterial endotoxins. The acute phase response that occurs after injury elicits the overproduction of several proteins by the liver, called acute phase proteins (APP). However, there are few studies using proteinogram to characterize the inflammatory response during the development of this syndrome. The aim of this study was to correlate APP values with clinical signs of horses submitted to carbohydrate overload (17.6 g.kg-1 BW of corn starch solution, administered via nasogastric tube) and treated with a buffer solution (3.5 g of aluminum hydroxide, 65.6 g of magnesium hydroxide and 1.2 g of simethicone, administered into the cecum through catheterization). Ten healthy horses were divided in a factorial and randomized way into four groups (n = 5): control (GCC), control + treatment (GCT), laminitis (GAC), laminitis + treatment (GAT). The animals from GCC and GAC integrated GAT and GCT, respectively, respecting an interval of 15 days between the experimental procedure. They were evaluated during seven moments (T0h, T4h, T8h, T12h, T24h, T48h, T72h), in which blood were also collected to obtain serum to perfo... (Complete abstract click electronic access below) / Mestre

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