The system of General Health Insurance was carried out since 1995 promoting the convenience for people seeking the medical care and helping a lot of medical disadvantaged minority. Moreover, this system also makes the medical resource differential obviously in the area of off-shore and main islands of Taiwan. The medical resource in main island of Taiwan is centralized and syndicated which reveals the helpless plight of poor medical resources and isolated geography in the remote area of off-shore islands conspicuously. This study researches into the mutual moderating effects of the doctors' perception of the work environment, job satisfaction, role stress, and intent to stay for the doctors in the off-shore islands of Penghu. This study retrieves 102 effective questionnaires by a census-taking. The collected data is carried on SPSS15.0 statistical analysis and test by utilizing t-test and ANOVA analysis to calculate the differences of the demographic statistics parameters, perception of the work environment, job satisfaction, role stress, and intent to stay in isolated island area. Moreover, the mutually influenced degree of constructs is scrutinized by multi-regression and path analyses. This research finds that: 1. Sufficient medical and human resources, good medical cooperation, and high working aspiration can improve the doctors' job satisfaction in the off-shore islands of Penghu. 2. Ample medical and human resources and good medical cooperation can reduce the role stress of doctors. 3. Application of the factors in stimulation and sound health care will lead negative and positive influences on doctors. 4. Good medical cooperation encourages the doctors to concentrate their attention on medical work and seldom interference in the doctor's medical work or values can further their intent to stay in the off-shore islands of Penghu.