Made available in DSpace on 2016-04-28T20:40:02Z (GMT). No. of bitstreams: 1 Aline Paiva Dantas.pdf: 586061 bytes, checksum: 678c98a12f09f65fe74a1d9d68afa076 (MD5) Previous issue date: 2009-05-08 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The present research proposes an investigation concerning the possible therapeutic effects of education, questioning the role of the school in relation to children with severe disorders of development. Therefore, it questions in which way the school can produce therapeutic effects capable to promote a shift of the subjective position of the autistic child, also reflecting on how psychoanalysis can bring up another look at education that implies a paradigm change in educational function. Towards this direction, the research presents the case of Ronaldo, a five year old boy, whose transference relationship that he establishes basically with me, educational guidance of his school, with his teacher and also with other members of his school, allowed the construction of significant links that had provided moments of exit of his autistic closing. Based on the conception of Alfredo Jerusalinsky (1993) deepened by Leda Bernardino (2000) on the not-determined psychoses of infancy, the emphasis on the subjective power of the discursive movement that permeates school space, represented the possibility of thinking about another outcome for the autistic condition of the boy. In this perspective, the investigation was carried through the study of Ronaldo´s case, by observing and listening to the teachers of the institution where the child was studying, considering operators of psychoanalysis / A presente pesquisa propõe uma investigação acerca dos possíveis efeitos terapêuticos da educação, problematizando a função da escola em relação às crianças com transtornos graves de desenvolvimento. Com isso, questiona em que medida a escola pode produzir efeitos terapêuticos capazes de promover um deslocamento da posição subjetiva da criança autista, refletindo também sobre como a psicanálise pode fazer surgir um outro olhar na educação que implique uma mudança paradigmática da função educativa. Tendo em vista esse direcionamento, a pesquisa apresenta o caso de Ronaldo, um garoto de cinco anos, cuja relação transferencial que estabelece fundamentalmente comigo, orientadora educacional de sua escola, com sua professora e também com os demais membros da instituição, permitiu a construção de laços significativos que proporcionaram momentos de saída do seu fechamento autístico. Tomando como base a concepção de Alfredo Jerusalinsky (1993), aprofundada por Leda Bernardino (2000), sobre as psicoses não-decididas da infância, a aposta no poder subjetivante da circulação discursiva que permeia o espaço escolar, representou a possibilidade de se pensar num outro desfecho para a condição autista do garoto. Nessa perspectiva, a investigação realizou-se através do estudo do caso de Ronaldo, observação e escuta dos professores da instituição onde ele estudava, tendo em vista operadores da psicanálise

SITUATION: Multiple sclerosis belongs to the most common chronic neurological disease of the central nervous system. The disease is incurable, however it is treatable. Modern medicine has a variety of medications to relieve the symptoms and slowing the onset and progression. In many cases, however, treatment is not effective and often causes side effects. Cannabis and its products are used in the symptomatic and causal therapy of many diseases. The efficacy of cannabis treatment in multiple sclerosis is confirmed by several studies. Medical cannabis is a way how to relieve pain and muscle spasms. In 2013 in the Czech Republic there have been changes in laws allowing prescribing cannabis for medical treatment. OBJECTIVES: The study's goal is to describe the issues of self-medication using medical cannabis from the perspective of people suffering from multiple sclerosis. The primary objective is to map the following areas: introduction to cannabis and motivation to self- medication, frequency and methods of self-medication, therapeutic effects experienced during self-medication, side effects experienced during self-medication, perspectives of cannabis use in the future. METHODOLOGY: Self-selection in combination with snowball sampling method was used to obtain survey respondents. Data in this study...

Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind or weakly bind. Examples of potential applications of this method in facilitating drug discovery include: (1) identification of unknown and secondary therapeutic targets of a drug, (2) prediction of potential toxicity and side effect of an investigative drug, and (3) probing molecular mechanism of bioactive herbal compounds such as those extracted from plants used in traditional medicines. This method and recent results on its applications in solving various drug discovery problems are reviewed. / Singapore-MIT Alliance (SMA)

The thesis was divided into two parts. The first part deals with selected long-term impacts of cannabis use and basic concepts such as history, methods of application, use or legislation. In order to understand the whole issue, the basic components of the cannabis plant and their effects. The main part of the theory was then devoted to the possibilities of social work in the field of addiction, but also health complications and therapeutic effects of cannabis. The first part was built on a professional basis literature that addresses this topic. As the work dealt with a very current topic, the latest HARP treatment program was also mentioned. In the second part of the work semi-structured interviews were performed in order to confirm the theoretical part of the work and bring a certain authenticity to the work. The goal was to offer to the reader comprehensive information about cannabis in one place, clearly and transparently. The negatives and the positives that this plant can cause as a result of use were analyzed.