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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"thermomechanical process"" "subject:"hermomechanical process""

1

Cocrystalization and simultaneous agglomeration using hot melt extrusion

Dhumal, Ravindra S., Kelly, Adrian L., York, Peter, Coates, Philip D., Paradkar, Anant R January 2010 (has links)
No / PURPOSE: To explore hot melt extrusion (HME) as a scalable, solvent-free, continuous technology to design cocrystals in agglomerated form. METHODS: Cocrystal agglomerates of ibuprofen and nicotinamide in 1:1 ratio were produced using HME at different barrel temperature profiles, screw speeds, and screw configurations. Product was characterized for crystallinity by XRPD and DSC, while the morphology was determined by SEM. Dissolution rate and tabletting properties were compared with ibuprofen. RESULTS: Process parameters significantly affected the extent of cocrystallization which improved with temperature, applied shear and residence time. Processing above eutectic point was required for cocrystallization to occur, and it improved with mixing intensity by changing screw configuration. Product was in the form of spherical agglomerates, which showed directly compressible nature with enhanced dissolution rate compared to ibuprofen. This marks an important advantage over the conventional techniques, as it negates the need for further size modification steps. CONCLUSIONS: A single-step, scalable, solvent-free, continuous cocrystallization and agglomeration technology was developed using HME, offering flexibility for tailoring the cocrystal purity. HME being an established technology readily addresses the regulatory demand of quality by design (QbD) and process analytical technology (PAT), offering high potential for pharmaceuticals.
Calorimetry
Chromatography
Crystallization
Hot temperature
Microscopy
Pharmaceutical preparations
Solubility
Spectrophotometry
X-Ray diffraction
REF 2014
Differential scanning
High pressure liquid
Cocrystals
Hot melt extrusion
Ibuprofen
Electron
Scanning
Chemistry
Ultraviolet
Thermo-mechanical process

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