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Modelling the response of cytotoxic t-lymphocytes in controlling solid tumour invasion.Malinzi, Joseph. 20 December 2013 (has links)
We present mathematical models to study the mechanism of interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We focus on the phase spaces of the systems and the nature of the solutions for the cell densities in the short and long term. The first model describes the production of offspring through cell proliferation, death and local kinetic interactions. The second model characterises the spatial distribution dynamics of the cell densities through reaction diffusion, which describes the random movement of the cells, and chemotaxis, which describes the immune cell movements towards the tumour cells. We then extend these models further to incorporate the effects of immunotherapy by developing two new models. In both situations, we analyse the phase spaces of the homogeneous models, investigate the presence of travelling wave solutions in our systems, and provide numerical simulations. Our analysis shows that cancer dormancy can be attributed to TICLs. Our study also
shows that TICLs reduce the tumour cell density to a cancer dormant state but even with immunotherapy do not completely eliminate tumour cells from body tissue. Travelling wave solutions were confirmed to exist in the heterogeneous model, a linear stability analysis of the homogeneous models and numerical simulations show the existence of a stable tumour dormant state and a phase space analysis confirms that there are no limit cycles. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2013.
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Solution generating algorithms in general relativity.Krupanandan, Daniel D. January 2011 (has links)
We conduct a comprehensive investigative review of solution generating algorithms
for the Einstein field equations governing the gravitational behaviour of an isolated
neutral static spherical distribution of perfect fluid matter. Traditionally, the master
field equation generated from the condition of pressure isotropy has been interpreted
as a second order ordinary differential equation. However, since the pioneering work
of Wyman (1949) it was observed that more success can be enjoyed by regarding
the equation as a first order linear differential equation. There was a resurgence
of the ideas of Wyman in 2000 and various researchers have been able to generate
complete solutions to the field equations up to certain integrations. These have
been accomplished by working in Schwarzschild (curvature) coordinates, isotropic
coordinates, area coordinates and a coordinate system written in terms of the redshift
parameter. We have utilised Durgapal–Banerjee (1983) coordinates and produced a
new algorithm. The algorithm is used to generate new classes of perfect fluid solutions
as well as to regain familiar particular solutions reported in the literature. We find
that our solution is well behaved according to elementary physical requirements.
The pressure vanishes for a certain radius and this establishes the boundary of the
distribution. Additionally the pressure and energy density are both positive inside
the radius. The energy conditions are shown to be satisfied and it is particularly
pleasing to have the causality criterion satisfied to ensure that the speed of light is
not exceeded by the speed of sound. We also report some new solutions using the
algorithms proposed by Lake (2006). / Thesis (M.Sc.)-University of KwaZulu-Natal, Westville, 2011.
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Exact solutions for relativistic models.Ngubelanga, Sifiso Allan. 31 October 2013 (has links)
In this thesis we study spherically symmetric spacetimes related to the Einstein field equations. We consider only neutral matter and apply the Einstein field equations with isotropic pressures. Our object is to model relativistic stellar systems. We express the Einstein field equations and the condition of pressure isotropy in terms of Schwarzschild coordinates and isotropic coordinates. For Schwarzschild coordinates we consider the
transformations due to Buchdahl (1959), Durgapal and Bannerji (1983), Fodor (2000) and Tewari and Pant (2010). The condition of pressure isotropy is integrated and new exact solutions of the field equations are obtained utilizing the transformations of Buchdahl (1959) and Tewari and Pant (2010). These exact solutions are given in terms of elementary functions. For isotropic coordinates we can express the condition of pressure isotropy as a Riccati equation or a linear equation. An algorithm is developed that produces a new solution if a particular solution is known. The transformations reduce to a nonlinear Bernoulli equation in most instances. There are fundamentally three new classes of solutions to the condition of pressure isotropy. / Thesis (M.Sc.)-University of KwaZulu-Natal, Westville, 2011.
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Applications of embedding theory in higher dimensional general relativity.Moodley, Jothi. 22 April 2014 (has links)
The study of embeddings is applicable and signicant to higher dimensional theories of
our universe, high-energy physics and classical general relativity. In this thesis we investigate
local and global isometric embeddings of four-dimensional spherically symmetric
spacetimes into five-dimensional Einstein manifolds. Theorems have been established
that guarantee the existence of such embeddings. However, most known explicit results
concern embedded spaces with relatively simple Ricci curvature. We consider the four-dimensional
gravitational field of a global monopole, a simple non-vacuum space with
a more complicated Ricci tensor, which is of theoretical interest in its own right, and
occurs as a limit in Einstein-Gauss-Bonnet Kaluza-Klein black holes, and we obtain
an exact solution for its embedding into Minkowski space. Our local embedding space
can be used to construct global embedding spaces, including a globally
at space and
several types of cosmic strings. We present an analysis of the result and comment on
its signicance in the context of induced matter theory and the Einstein-Gauss-Bonnet
gravity scenario where it can be viewed as a local embedding into a Kaluza-Klein black
hole. Difficulties in solving the five-dimensional equations for given four-dimensional
spaces motivate us to investigate which embedded spaces admit bulks of a specific type.
We show that the general Schwarzschild-de Sitter spacetime and the Einstein Universe
are the only spherically symmetric spacetimes that can be embedded into an Einstein
space with a particular metric form, and we discuss their five-dimensional solutions.
Furthermore, we determine that the only spherically symmetric spacetime in retarded
time coordinates that can be embedded into a particular Einstein bulk is the general
Vaidya-de Sitter solution with constant mass. These analyses help to provide insight to
the general embedding problem. We also consider the conformal Killing geometry of a
five-dimensional Einstein space that embeds a static spherically symmetric spacetime,
and we show how the Killing geometry of the embedded space is inherited by its bulk.
The study of embedding properties such as these enables a deeper mathematical understanding
of higher dimensional cosmological models and is also of physical interest
as conformal symmetries encode conservation laws. / Thesis (Ph.D.)-University of KwaZulu-Natal, Durban, 2012.
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An adaptive feature-based tracking systemPretorius, Eugene 03 1900 (has links)
Thesis (MSc (Mathematical Sciences. Applied Mathematics))--University of Stellenbosch, 2008. / In this paper, tracking tools are developed based on object features to robustly track the object using particle filtering. Automatic on-line initialisation techniques use motion detection and dynamic background modelling to extract features of moving objects. Automatically adapting the feature models during tracking is implemented and tested.
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A numerical study of the spectrum of the nonlinear Schrodinger equationOlivier, Carel Petrus 12 1900 (has links)
Thesis (MSc (Mathematical Sciences. Applied Mathematics))--Stellenbosch University, 2008. / The NLS is a universal equation of the class of nonlinear integrable systems. The
aim of this thesis is to study the NLS numerically. More speci cally, an algorithm is
developed to calculate its nonlinear spectrum. The nonlinear spectrum is then used
as a diagnostic for numerical studies of the NLS. The spectrum consists of a discrete
part, further subdivided into the main part, the auxiliary part, and the continuous
spectrum. Two algorithms are developed for calculating the main spectrum. One is
based on Floquet theory, rst implemented by Overman [12]. The other is a direct
calculation of the eigenvalues by Herbst and Weideman [16]. These algorithms
are combined through the marching squares algorithm to calculate the continuous
spectrum. All ideas are illustrated by numerical examples.
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Automated face detection and recognition for a login systemLouw, Lloyd A. B. 03 1900 (has links)
Thesis (MScEng (Mathematical Sciences. Applied Mathematics))--University of Stellenbosch, 2007. / The face is one of the most characteristic parts of the human body and has been used
by people for personal identification for centuries. In this thesis an automatic process for
frontal face recognition from 2–dimensional images is presented based on principal component
analysis. The goal is to use these concepts in eventual face–recognizing login software.
The first step is detecting faces in images that are allowed a certain degree of clutter.
This is achieved by skin colour detection in the HSV colourspace. This process indicates
the area of the image most likely corresponding to the face. Extracting the face is achieved
by morphological processing of this area of the image. The face is then normalized by
a transformation that uses the eye coordinates as input. Automatic eye detection is implemented
based on colour analysis of the facial images and a 91.1% success rate is achieved.
Recognition of the normalized faces is achieved using eigenfaces. To calculate these, a
large enough database of facial images is needed. The xm2vts database is used in this
thesis as the images have very constant lighting conditions throughout – an important
factor affecting the accuracy of the recognition stage. Distinction is also made between
identification and verification of faces. For identification, up to 80.1% accuracy is achieved,
while for verification, the equal error rate is approximately 3.5%.
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A survey of computational methods for pricing Asian optionsNieuwveldt, Fernando Damian 03 1900 (has links)
Thesis (MSc (Mathematical Sciences. Applied Mathematics))--University of Stellenbosch, 2009. / In this thesis, we investigate two numerical methods to price nancial options.
We look at two types of options, namely European options and
Asian options. The numerical methods we use are the nite di erence
method and numerical inversion of the Laplace transform. We apply nite
di erence methods to partial di erential equations with both uniform and
non-uniform spatial grids. The Laplace inversion method we use is due to
Talbot. It is based on the midpoint-type approximation of the Bromwich
integral on a deformed contour. When applied to Asian options, we have
the problem of computing the hypergeometric function of the rst kind.
We propose a new method for numerically calculating the hypergeometric
function. This method too is based on using Talbot contours. Throughout
the thesis, we use the Black-Scholes equation as our benchmark problem.
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Spectral difference methods for solving equations of the KdV hierarchyPindza, Edson 03 1900 (has links)
Thesis (MSc (Applied Mathematics))--Stellenbosch University, 2008. / The Korteweg-de Vries (KdV) hierarchy is an important class of nonlinear evolution equa-
tions with various applications in the physical sciences and in engineering.
In this thesis analytical solution methods were used to ¯nd exact solutions of the third and
¯fth order KdV equations, and numerical methods were used to compute numerical solutions
of these equations.
Analytical methods used include the Fan sub-equation method for constructing exact trav-
eling wave solutions, and the simpli¯ed Hirota method for constructing exact N-soliton
solutions. Some well known cases were considered.
The Fourier spectral method and the ¯nite di®erence method with Runge-Kutta time dis-
cretisation were employed to solve the third and the ¯fth order KdV equations with periodic
boundary conditions. The one soliton and the two soliton solutions were used as initial
conditions. The numerical solutions are obtained and compared with the exact solutions.
The propagation of a single soliton as well as the interaction of double soliton solutions is
modeled well by both numerical methods, although the Fourier spectral method performs
better.
The stability, consistency and convergence of these numerical methods were investigated.
Error propagation is studied. The theoretically predicted quadratic convergence of the ¯nite
di®erence method as well as the exponential convergence of the Fourier spectral method is
con¯rmed in numerical experiments.
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An application of photogrammetry in the petrochemical industrySingels, Wynand 03 1900 (has links)
Thesis (MScEng (Mathematical Sciences. Applied Mathematics))--Stellenbosch University, 2008. / When building or improving a petrochemical plant, drawings are used extensively
in the design process. However, existing petrochemical plants seldom
match their drawings, or the drawings are lost, forcing the need to generate
a 3D model of the structure of the plant. In this thesis photogrammetry is investigated
as a method of generating a digital 3D model of an existing plant.
Camera modeling, target extraction and 3D reconstruction are discussed in
detail, and a real-world system is investigated.
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