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Thrombosis is the pathological formation of platelet aggregates that cause stroke and heart attack\textemdash the leading causes of death in developed nations. Determining effective dosages for platelet therapies (e.g. aspirin, Integrilin, and Plavix) to prevent thrombosis is a persistent medical challenge (studies estimate up to 45% of patients exhibit insufficient responses to these drugs) and recent studies have implicated pathological flow conditions of high shear rates and stenosis morphology as primary factors. However, there are currently no diagnostic instruments able to recapitulate a range of such pathological flow conditions for evaluating thrombosis with and without these drugs. In this work, a microfluidic device and associated optical system were designed and fabricated for simultaneous measurement of platelet aggregation at multiple initial wall shear rates within multiple stenotic channels in label-free whole blood and used to characterize thrombosis at varying dosages of two platelet therapies: acetyl-salicylic acid (aspirin) and eptifibatide (Integrilin). Results from our studies show the effects of pathologically high shear rates on enhancing platelet thrombosis and demonstrate the widely varied, shear-dependent efficacy of each therapy. This study lays the foundation for the future development of a medical diagnostic for optimizing the type and dosage of patient platelet therapy and to better understand their mechanisms of action.

Background: Thrombosis is a common and critical consequence of cancer. Changes in thrombotic potential were examined after exercise training in patients with cancer. Methods: Eight cancer patients (65 ± 11 yrs) completed this study, five exercising and three non-exercising controls. Venous blood samples were obtained at baseline and after approximately 12 weeks of study participation. Weekly physical activity was measured using a standard, validated physical activity questionnaire. APTT, PT, fibrinogen and factor VIII were measured before and after the 12-week intervention. Results: A time x group interaction trend (p=0.067) was observed for fibrinogen. Plasma concentrations decreased in the exercise group (355 ± 49.3 mg/dL to 331 ± 19.5 mg/dL), but increased in the control group (341 ± 52.4 mg/dL to 384 ± 107.9 mg/dL). Physical activity significantly decreased over time in both groups. Conclusions: Exercise training may reduce coagulation potential in cancer patients more than usual and customary care. / School of Physical Education, Sport, and Exercise Science

Thesis (MAppSc (Medical Laboratory Science)) --University of South Australia, 1992

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2006. / Härtil 4 uppsatser.

Thesis (Ph.D. in Clinical Science) -- University of Colorado Denver, 2008. / Typescript. Includes bibliographical references (leaves 136-146). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

Thesis (Ph. D.)--Duke University, 2008.

Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (M. Eng.)--Carleton University, 1995. / Also available in electronic format on the Internet.

Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted. Includes bibliographical references.